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Byoung Heon Kang
Byoung Heon Kang
UNIST, South Korea
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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network
BH Kang, J Plescia, T Dohi, J Rosa, SJ Doxsey, DC Altieri
Cell 131 (2), 257-270, 2007
5152007
Hsp60 regulation of tumor cell apoptosis
JC Ghosh, T Dohi, BH Kang, DC Altieri
Journal of Biological Chemistry 283 (8), 5188-5194, 2008
3762008
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
BH Kang, J Plescia, HY Song, M Meli, G Colombo, K Beebe, B Scroggins, ...
The Journal of clinical investigation 119 (3), 454-464, 2009
2512009
Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1
C Lee, HK Park, H Jeong, J Lim, AJ Lee, KY Cheon, CS Kim, AP Thomas, ...
Journal of the American Chemical Society 137 (13), 4358-4367, 2015
1232015
Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein
BH Kang, DC Altieri
Journal of Biological Chemistry 281 (34), 24721-24727, 2006
1032006
Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer
BH Kang, MD Siegelin, J Plescia, CM Raskett, DS Garlick, T Dohi, JB Lian, ...
Clinical Cancer Research 16 (19), 4779-4788, 2010
992010
Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
HK Park, JH Hong, YT Oh, SS Kim, J Yin, AJ Lee, YC Chae, JH Kim, ...
Cancer research 79 (7), 1369-1382, 2019
892019
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
HK Park, NG Yoon, JE Lee, S Hu, S Yoon, SY Kim, JH Hong, D Nam, ...
Experimental & molecular medicine 52 (1), 79-91, 2020
862020
TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors
BH Kang
BMB reports 45 (1), 1-6, 2012
752012
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
BH Kang, M Tavecchio, HL Goel, CC Hsieh, DS Garlick, CM Raskett, ...
British journal of cancer 104 (4), 629-634, 2011
712011
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
BH Kang, DC Altieri
Oncogene 28 (42), 3681-3688, 2009
642009
Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim
HK Park, JE Lee, J Lim, DE Jo, SA Park, PG Suh, BH Kang
BMC cancer 14, 1-9, 2014
632014
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein
BH Kang, F Xia, R Pop, T Dohi, M Socolovsky, DC Altieri
Journal of Biological Chemistry 286 (19), 16758-16767, 2011
522011
Paralog specificity determines subcellular distribution, action mechanism, and anticancer activity of TRAP1 inhibitors
HK Park, H Jeong, E Ko, G Lee, JE Lee, SK Lee, AJ Lee, JY Im, S Hu, ...
Journal of Medicinal Chemistry 60 (17), 7569-7578, 2017
452017
Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells
HK Park, JE Lee, J Lim, BH Kang
Molecular cancer 13, 1-14, 2014
452014
Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinoma
JE Lee, AJ Lee, DE Jo, JH Cho, K Youn, EY Yun, JS Hwang, M Jun, ...
Journal of the Korean Society of Food Science and Nutrition 44 (2), 200-207, 2015
432015
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-¥â3 (PLC-¥â3)-specific activation of somatostatin by forming a ternary complex with PLC-¥â3 and somatostatin ¡¦
JK Kim, O Kwon, J Kim, EK Kim, HK Park, JE Lee, KL Kim, JW Choi, S Lim, ...
Journal of Biological Chemistry 287 (25), 21012-21024, 2012
332012
The structure of procaspase 6 is similar to that of active mature caspase 6
BH Kang, E Ko, OK Kwon, KY Choi
Biochemical Journal 364 (3), 629-634, 2002
312002
The novel resveratrol derivative 3, 5-diethoxy-3¡Ç, 4¡Ç-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro
J Park, W Choi, P Lee, S Chung, B Kim, H Chung, S Cho, J Kim, B Kang, ...
Acta Pharmacologica Sinica 38 (11), 1486-1500, 2017
272017
Hepatoprotective and anticancer activities of Allomyrina dichotoma larvae
JE Lee, DE Jo, AJ Lee, HK Park, K Youn, EY Yun, JS Hwang, M Jun, ...
Journal of Life Science 25 (3), 307-316, 2015
272015
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