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Fu-Yang (Albert) Lin, PhD
Fu-Yang (Albert) Lin, PhD
Morphic Therapeutic
Verified email at crystal.harvard.edu
Title
Cited by
Cited by
Year
Terpene biosynthesis: modularity rules
E Oldfield, FY Lin
Angewandte Chemie International Edition 51 (5), 1124-1137, 2012
4142012
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
Y Zhang, R Cao, F Yin, MP Hudock, RT Guo, K Krysiak, S Mukherjee, ...
Journal of the American Chemical Society 131 (14), 5153-5162, 2009
2072009
Diterpene cyclases and the nature of the isoprene fold
R Cao, Y Zhang, FM Mann, C Huang, D Mukkamala, MP Hudock, ...
Proteins: Structure, Function, and Bioinformatics 78 (11), 2417-2432, 2010
1562010
Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus: In Vitro, in Vivo, and Crystallographic Results
Y Song, CI Liu, FY Lin, JH No, M Hensler, YL Liu, WY Jeng, J Low, GY Liu, ...
Journal of medicinal chemistry 52 (13), 3869-3880, 2009
1092009
E339… R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors
YF Shen, YH Chen, SY Chu, MI Lin, HT Hsu, PY Wu, CJ Wu, HW Liu, ...
Proceedings of the National Academy of Sciences 108 (40), 16515-16520, 2011
942011
Mechanism of action and inhibition of dehydrosqualene synthase
FY Lin, CI Liu, YL Liu, Y Zhang, K Wang, WY Jeng, TP Ko, R Cao, ...
Proceedings of the National Academy of Sciences 107 (50), 21337-21342, 2010
902010
Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus
Y Song, FY Lin, F Yin, M Hensler, CA Rodrigues Poveda, D Mukkamala, ...
Journal of medicinal chemistry 52 (4), 976-988, 2009
832009
Lipophilic Pyridinium Bisphosphonates: Potent γδ T Cell Stimulators
Y Zhang, R Cao, F Yin, FY Lin, H Wang, K Krysiak, JH No, D Mukkamala, ...
Angewandte Chemie International Edition 49 (6), 1136-1138, 2010
822010
Calcium-and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP
IB Ramos, K Miranda, DA Pace, KC Verbist, FY Lin, Y Zhang, E Oldfield, ...
Biochemical journal 429 (3), 485-495, 2010
452010
β-Subunit binding is sufficient for ligands to open the integrin αIIbβ3 headpiece
FY Lin, J Zhu, ET Eng, NE Hudson, TA Springer
Journal of Biological Chemistry 291 (9), 4537-4546, 2016
362016
Terpen‐Biosynthese: Modularitätsregeln
E Oldfield, FY Lin
Angewandte Chemie 124 (5), 1150-1163, 2012
342012
Head-to-head prenyl tranferases: anti-infective drug targets
FY Lin, YL Liu, K Li, R Cao, W Zhu, J Axelson, R Pang, E Oldfield
Journal of medicinal chemistry 55 (9), 4367-4372, 2012
272012
HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis
Y Zhang, FY Lin, K Li, W Zhu, YL Liu, R Cao, R Pang, E Lee, J Axelson, ...
ACS medicinal chemistry letters 3 (5), 402-406, 2012
252012
A general chemical principle for creating closure-stabilizing integrin inhibitors
FY Lin, J Li, Y Xie, J Zhu, TTH Nguyen, Y Zhang, J Zhu, TA Springer
Cell 185 (19), 3533-3550. e27, 2022
212022
Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System Based Therapeutics
FY Lin, Y Zhang, M Hensler, YL Liu, OA Chow, W Zhu, K Wang, R Pang, ...
ChemMedChem 7 (4), 561, 2012
212012
High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate
X Dong, B Zhao, FY Lin, C Lu, BN Rogers, TA Springer
Proceedings of the National Academy of Sciences 115 (7), E1429-E1436, 2018
172018
NMR structure note-Solution structure of a bacterial BolA-like protein XC975 from a plant pathogenXanthomonas campestrispv. campestris.
KH Chin, FY Lin, YC Hu, K Sze, PC Lyu, SH Chou
Journal of Biomolecular NMR 31 (2), 2005
152005
Inhibition of integrin αvβ8 enhances immune checkpoint induced anti-tumor immunity by acting across immunologic synapse in syngeneic models of breast cancer
NJ Reszka-Blanco, V Yadav, M Krumpoch, L Cappellucci, D Cui, ...
Cancer Research 81 (13_Supplement), 1559-1559, 2021
32021
A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding
SP Boudko, EH Konopka, W Kim, Y Taga, K Mizuno, TA Springer, ...
Journal of Biological Chemistry 299 (7), 2023
22023
A putative polyketide-synthesis protein XC5357 from Xanthomonas campestris: heterologous expression, crystallization and preliminary X-ray analysis
CL Chu, KH Chin, FY Lin, CC Chou, CC Lee, HL Shr, PC Lyu, AHJ Wang, ...
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2005
22005
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Articles 1–20