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Daniel G. Isom
Daniel G. Isom
University of Miami School of Medicine
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Large shifts in pKa values of lysine residues buried inside a protein
DG Isom, CA Castañeda, BR Cannon, B García-Moreno E
Proceedings of the National Academy of Sciences 108 (13), 5260-5265, 2011
5162011
Charges in the hydrophobic interior of proteins
DG Isom, CA Castañeda, BR Cannon, PD Velu, B García-Moreno E
Proceedings of the National Academy of Sciences 107 (37), 16096-16100, 2010
2662010
The pKa values of acidic and basic residues buried at the same internal location in a protein are governed by different factors
MJ Harms, CA Castañeda, JL Schlessman, GR Sue, DG Isom, ...
Journal of molecular biology 389 (1), 34-47, 2009
1742009
High tolerance for ionizable residues in the hydrophobic interior of proteins
DG Isom, BR Cannon, CA Castañeda, A Robinson, B García-Moreno E
Proceedings of the National Academy of Sciences 105 (46), 17784-17788, 2008
1712008
Local secondary structure content predicts folding rates for simple, two-state proteins
H Gong, DG Isom, R Srinivasan, GD Rose
Journal of molecular biology 327 (5), 1149-1154, 2003
1452003
One year of SARS-CoV-2: how much has the virus changed?
S Vilar, DG Isom
Biology 10 (2), 91, 2021
1342021
Protons as second messenger regulators of G protein signaling
DG Isom, V Sridharan, R Baker, ST Clement, DM Smalley, HG Dohlman
Molecular cell 51 (4), 531-538, 2013
962013
Mutations in ATP1A1 cause dominant Charcot-Marie-Tooth type 2
P Lassuthova, AP Rebelo, G Ravenscroft, PJ Lamont, MR Davis, ...
The American Journal of Human Genetics 102 (3), 505-514, 2018
832018
Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination
R Baker, EM Wilkerson, K Sumita, DG Isom, AT Sasaki, HG Dohlman, ...
Journal of Biological Chemistry 288 (52), 36856-36862, 2013
792013
DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery
NJ Kapolka, GJ Taghon, JB Rowe, WM Morgan, JF Enten, NA Lambert, ...
Proceedings of the National Academy of Sciences 117 (23), 13117-13126, 2020
672020
Hydration of the folding transition state ensemble of a protein
L Brun, DG Isom, P Velu, B García-Moreno, CA Royer
Biochemistry 45 (11), 3473-3480, 2006
582006
Predictable cholesterol binding sites in GPCRs lack consensus motifs
GJ Taghon, JB Rowe, NJ Kapolka, DG Isom
Structure 29 (5), 499-506. e3, 2021
572021
The evolution and mechanism of GPCR proton sensing
JB Rowe, NJ Kapolka, GJ Taghon, WM Morgan, DG Isom
Journal of Biological Chemistry 296, 2021
512021
Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation
DG Isom, HG Dohlman
Proceedings of the National Academy of Sciences 112 (18), 5702-5707, 2015
502015
V i-value analysis: a pressure-based method for mapping the folding transition state ensemble of proteins
L Mitra, K Hata, R Kono, A Maeno, D Isom, JB Rouget, R Winter, ...
Journal of the American Chemical Society 129 (46), 14108-14109, 2007
392007
A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity
DG Isom, PR Marguet, TG Oas, HW Hellinga
Proteins: Structure, Function, and Bioinformatics 79 (4), 1034-1047, 2011
362011
Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity
DG Isom, E Vardy, TG Oas, HW Hellinga
Proceedings of the National Academy of Sciences 107 (11), 4908-4913, 2010
362010
Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast
DG Isom, SC Page, LB Collins, NJ Kapolka, GJ Taghon, HG Dohlman
Journal of Biological Chemistry 293 (7), 2318-2329, 2018
322018
Amino acid metabolites that regulate G protein signaling during osmotic stress
JP Shellhammer, E Morin-Kensicki, JP Matson, G Yin, DG Isom, ...
PLoS Genetics 13 (5), e1006829, 2017
272017
Proton-gated coincidence detection is a common feature of GPCR signaling
NJ Kapolka, JB Rowe, GJ Taghon, WM Morgan, CR O¡¯shea, DG Isom
Proceedings of the National Academy of Sciences 118 (28), e2100171118, 2021
242021
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