| Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ... Science 334 (6060), 1278-1283, 2011 | 1221 | 2011 |
| Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011 | 1167 | 2011 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 801 | 2012 |
| Systemic elevation of PTEN induces a tumor-suppressive metabolic state I Garcia-Cao, MS Song, RM Hobbs, G Laurent, C Giorgi, VCJ De Boer, ... Cell 149 (1), 49-62, 2012 | 431 | 2012 |
| The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II A Yart, M Gstaiger, C Wirbelauer, M Pecnik, D Anastasiou, D Hess, ... Molecular and cellular biology 25 (12), 5052-5060, 2005 | 217 | 2005 |
| mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis D Kalaitzidis, SM Sykes, Z Wang, N Punt, Y Tang, C Ragu, AU Sinha, ... Cell stem cell 11 (3), 429-439, 2012 | 197 | 2012 |
| Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors AT Sasaki, A Carracedo, JW Locasale, D Anastasiou, K Takeuchi, ... Science signaling 4 (163), ra13-ra13, 2011 | 186 | 2011 |
| SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology D Anastasiou, W Krek Physiology 21 (6), 404-410, 2006 | 128 | 2006 |
| mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis B Selvarajah, I Azuelos, M Platé, D Guillotin, EJ Forty, G Contento, ... Science signaling 12 (582), eaav3048, 2019 | 126 | 2019 |
| PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation A Gupta, S Anjomani-Virmouni, N Koundouros, M Dimitriadi, ... Molecular cell 65 (6), 999-1013. e7, 2017 | 126 | 2017 |
| Tumour microenvironment factors shaping the cancer metabolism landscape D Anastasiou British journal of cancer 116 (3), 277-286, 2017 | 125 | 2017 |
| IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma S Kofuji, A Hirayama, AO Eberhardt, R Kawaguchi, Y Sugiura, ... Nature cell biology 21 (8), 1003-1014, 2019 | 118 | 2019 |
| Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer M Morotti, E Bridges, A Valli, H Choudhry, H Sheldon, S Wigfield, N Gray, ... Proceedings of the National Academy of Sciences 116 (25), 12452-12461, 2019 | 107 | 2019 |
| Breathless cancer cells get fat on glutamine. D Anastasiou, LC Cantley Cell research 22, 443-446, 2012 | 79 | 2012 |
| The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis K Sumita, YH Lo, K Takeuchi, M Senda, S Kofuji, Y Ikeda, J Terakawa, ... Molecular cell 61 (2), 187-198, 2016 | 69 | 2016 |
| Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis B Selvarajah, I Azuelos, D Anastasiou, RC Chambers Science Signaling 14 (697), eaay1027, 2021 | 39 | 2021 |
| Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation JA Macpherson, A Theisen, L Masino, L Fets, PC Driscoll, V Encheva, ... Elife 8, e45068, 2019 | 39 | 2019 |
| An engineered photoswitchable mammalian pyruvate kinase S Gehrig, JA Macpherson, PC Driscoll, A Symon, SR Martin, JI MacRae, ... The FEBS journal 284 (18), 2955-2980, 2017 | 30 | 2017 |
| MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG L Fets, PC Driscoll, F Grimm, A Jain, PM Nunes, M Gounis, G Doglioni, ... Nature chemical biology 14 (11), 1032-1042, 2018 | 23 | 2018 |
| Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design JA Macpherson, D Anastasiou Current opinion in biotechnology 48, 102-110, 2017 | 13 | 2017 |
Lewis CantleyDana Farber Cancer Center and Harvard Medical SchoolVerified email at med.cornell.edu
