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Hirotsugu Usutani (臼谷弘次)
Hirotsugu Usutani (臼谷弘次)
Associate Director, Process Chemistry Laboratories, Sumitomo Pharma
Verified email at takeda.com
Title
Cited by
Cited by
Year
Generation and Reactions of o-Bromophenyllithium without Benzyne Formation Using a Microreactor
H Usutani, Y Tomida, A Nagaki, H Okamoto, T Nokami, J Yoshida
Journal of the American Chemical Society 129 (11), 3046-3047, 2007
2882007
Integrated Micro Flow Synthesis Based on Sequential Br–Li Exchange Reactions of p‐, m‐, and o‐Dibromobenzenes
A Nagaki, Y Tomida, H Usutani, H Kim, N Takabayashi, T Nokami, ...
Chemistry–An Asian Journal 2 (12), 1513-1523, 2007
1172007
Generation and reaction of cyano-substituted aryllithium compounds using microreactors
A Nagaki, H Kim, H Usutani, C Matsuo, J Yoshida
Organic & biomolecular chemistry 8 (5), 1212-1217, 2010
1102010
Development and scale-up of a flow chemistry lithiation–borylation route to a key boronic acid starting material
H Usutani, T Nihei, CD Papageorgiou, DG Cork
Organic process research & development 21 (4), 669-673, 2017
402017
Effective utilization of flow chemistry: use of unstable intermediates, inhibition of side reactions, and scale-up for boronic acid synthesis
H Usutani, DG Cork
Organic Process Research & Development 22 (6), 741-746, 2018
122018
Application of continuous flow-flash chemistry to scale-up synthesis of 5-cyano-2-formylbenzoic acid
M Seto, S Masada, H Usutani, DG Cork, K Fukuda, T Kawamoto
Organic Process Research & Development 23 (7), 1420-1428, 2019
72019
Construction of a (3aR,4R,9bR)-Hexahydropyrroloquinoline by Stereoselective Hydrogen-Mediated Domino Cyclization
M Yamada, H Usutani, T Ito, M Yamano
Organic Process Research & Development 23 (4), 535-547, 2019
62019
Process Intensification of a Napabucasin Manufacturing Method Utilizing Microflow Chemistry
H Usutani, K Yamamoto, K Hashimoto
ACS omega 8 (11), 10373-10382, 2023
32023
Rapid and efficient synthesis of a novel cholinergic muscarinic M 1 receptor positive allosteric modulator using flash chemistry
S Miura, K Fukuda, S Masada, H Usutani, M Kanematsu, DG Cork, ...
Organic & Biomolecular Chemistry 17 (35), 8166-8174, 2019
32019
Rhodium catalyst and method for producing amine compound
M Yamano, M Yamada, H Usutani
US Patent 9,238,667, 2016
32016
Flow Chemistry Processes for Reactions Utilizing Unstable Intermediates: Applications Toward Pharmaceutical Production
H Usutani
2020
Synthesis of a TAK-480 Fragment
P Kocienski
Synfacts 15 (08), 0843, 2019
2019
Bromine-Lithium Exchange on Cyano-Substituted Arenes Using Microreactors
A Nagaki, H Kim, H Usutani, C Matsuo, J Yoshida
Synfacts 2010 (05), 0582-0582, 2010
2010
Generation and reaction of cyano-substituted aryllithium compounds using microreactors
J Yoshida, C Matsuo, H Kim, A Nagaki, H Usutani
The Royal Society of Chemistry, 2010
2010
Sequential integration of Br-Li exchange reactions using microflow systems
Y Tomida, A Nagaki, H Usutani, H Kim, N Takabayashi, T Nokami, ...
2008 AIChE Spring National Meeting, Conference, 2008
2008
Generation and reactions of ortho-bromophenyllithium without benzyne formation using microflow system
A Nagaki, H Usutani, Y Tomida, H Kim, N Takabayashi, T Nokami, ...
10th International Conference on Microreaction Technology, IMRET 2008 …, 2008
2008
Spotlights…
A Nagaki, Y Tomida, H Usutani, H Kim, N Takabayashi, T Nokami, ...
Angew. Chem. Int. Ed 46, 8936-8937, 2007
2007
Cation Pool Method Based on CC Bond Dissociation. Effective Genergation of Monocations and Dications
JI Yoshida, M Okajima, H Usutani, T Nokami, K Itami, S Suga
ECS Meeting Abstracts, 951, 2006
2006
Supplementary Material (ESI) for Organic and Biomolecular Chemistry Generation and Reaction of Cyano-Substituted Aryllithium Compounds Using Microreactors
A Nagaki, H Kim, H Usutani, C Matsuo, J Yoshida
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Articles 1–19