| Mechanical and chemical unfolding of a single protein: a comparison M Carrion-Vazquez, AF Oberhauser, SB Fowler, PE Marszalek, ... Proceedings of the National Academy of Sciences 96 (7), 3694-3699, 1999 | 1257 | 1999 |
| Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation J Clarke, AR Fersht Biochemistry 32 (16), 4322-4329, 1993 | 480 | 1993 |
| The folding and evolution of multidomain proteins JH Han, S Batey, AA Nickson, SA Teichmann, J Clarke Nature reviews Molecular cell biology 8 (4), 319-330, 2007 | 424 | 2007 |
| Single-molecule studies of protein folding A Borgia, PM Williams, J Clarke Annu. Rev. Biochem. 77 (1), 101-125, 2008 | 399 | 2008 |
| The importance of sequence diversity in the aggregation and evolution of proteins CF Wright, SA Teichmann, J Clarke, CM Dobson Nature 438 (7069), 878-881, 2005 | 384 | 2005 |
| Atomic force microscopy reveals the mechanical design of a modular protein H Li, AF Oberhauser, SB Fowler, J Clarke, JM Fernandez Proceedings of the National Academy of Sciences 97 (12), 6527-6531, 2000 | 331 | 2000 |
| Hidden complexity in the mechanical properties of titin PM Williams, SB Fowler, RB Best, J Luis Toca-Herrera, KA Scott, ... Nature 422 (6930), 446-449, 2003 | 315 | 2003 |
| Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors S Milles, D Mercadante, IV Aramburu, MR Jensen, N Banterle, C Koehler, ... Cell 163 (3), 734-745, 2015 | 297 | 2015 |
| Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation RB Best, B Li, A Steward, V Daggett, J Clarke Biophysical journal 81 (4), 2344-2356, 2001 | 285 | 2001 |
| The structure of a PKD domain from polycystin‐1: implications for polycystic kidney disease M Bycroft, A Bateman, J Clarke, SJ Hamill, R Sandford, RL Thomas, ... The EMBO journal, 1999 | 257 | 1999 |
| Folding studies of immunoglobulin-like β-sandwich proteins suggest that they share a common folding pathway J Clarke, E Cota, SB Fowler, SJ Hamill Structure 7 (9), 1145-1153, 1999 | 252 | 1999 |
| Mapping the folding pathway of an immunoglobulin domain: structural detail from phi value analysis and movement of the transition state SB Fowler, J Clarke Structure 9 (5), 355-366, 2001 | 234 | 2001 |
| Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering SB Fowler, RB Best, JLT Herrera, TJ Rutherford, A Steward, E Paci, ... Journal of molecular biology 322 (4), 841-849, 2002 | 232 | 2002 |
| The folding of an immunoglobulin-like Greek key protein is defined by a common-core nucleus and regions constrained by topology SJ Hamill, A Steward, J Clarke Journal of Molecular Biology 297 (1), 165-178, 2000 | 219 | 2000 |
| Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding KB Wong, J Clarke, CJ Bond, JL Neira, SMV Freund, AR Fersht, ... Journal of Molecular Biology 296 (5), 1257-1282, 2000 | 208 | 2000 |
| Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins MB Borgia, A Borgia, RB Best, A Steward, D Nettels, B Wunderlich, ... Nature 474 (7353), 662-665, 2011 | 199 | 2011 |
| Mechanical unfolding of a titin Ig domain: structure of transition state revealed by combining atomic force microscopy, protein engineering and molecular dynamics simulations RB Best, SB Fowler, JLT Herrera, A Steward, E Paci, J Clarke Journal of molecular biology 330 (4), 867-877, 2003 | 196 | 2003 |
| Parallel protein-unfolding pathways revealed and mapped CF Wright, K Lindorff-Larsen, LG Randles, J Clarke Nature Structural & Molecular Biology 10 (8), 658-662, 2003 | 194 | 2003 |
| Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family BG Wensley, S Batey, FAC Bone, ZM Chan, NR Tumelty, A Steward, ... Nature 463 (7281), 685-688, 2010 | 193 | 2010 |
| Folding and stability of a fibronectin type III domain of human tenascin J Clarke, SJ Hamill, CM Johnson Journal of molecular biology 270 (5), 771-778, 1997 | 189 | 1997 |
