Aashish Manglik
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
A Manglik, AC Kruse, TS Kobilka, FS Thian, JM Mathiesen, RK Sunahara, ...
Nature 485 (7398), 321-326, 2012
Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
Structure-based discovery of opioid analgesics with reduced side effects
A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ...
Nature 537 (7619), 185-190, 2016
The dynamic process of β2-adrenergic receptor activation
R Nygaard, Y Zou, RO Dror, TJ Mildorf, DH Arlow, A Manglik, AC Pan, ...
Cell 152 (3), 532-542, 2013
Structural insights into µ-opioid receptor activation
W Huang, A Manglik, AJ Venkatakrishnan, T Laeremans, EN Feinberg, ...
Nature 524 (7565), 315-321, 2015
Structure of the δ-opioid receptor bound to naltrindole
S Granier, A Manglik, AC Kruse, TS Kobilka, FS Thian, WI Weis, ...
Nature 485 (7398), 400-404, 2012
Structural insights into the dynamic process of β2-adrenergic receptor signaling
A Manglik, TH Kim, M Masureel, C Altenbach, Z Yang, D Hilger, MT Lerch, ...
Cell 161 (5), 1101-1111, 2015
Structure of the µ-opioid receptor–Gi protein complex
A Koehl, H Hu, S Maeda, Y Zhang, Q Qu, JM Paggi, NR Latorraca, ...
Nature 558 (7711), 547-552, 2018
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
AM Ring, A Manglik, AC Kruse, MD Enos, WI Weis, KC Garcia, BK Kobilka
Nature 502 (7472), 575-579, 2013
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ...
Science 370 (6521), eabe9403, 2020
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ...
Nature 497 (7447), 137-141, 2013
Crystal structure of the human σ1 receptor
HR Schmidt, S Zheng, E Gurpinar, A Koehl, A Manglik, AC Kruse
Nature 532 (7600), 527-530, 2016
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging
RL Maute, SR Gordon, AT Mayer, MN McCracken, A Natarajan, NG Ring, ...
Proceedings of the National Academy of Sciences 112 (47), E6506-E6514, 2015
Yeast surface display platform for rapid discovery of conformationally selective nanobodies
C McMahon, AS Baier, R Pascolutti, M Wegrecki, S Zheng, JX Ong, ...
Nature structural & molecular biology 25 (3), 289-296, 2018
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ...
Science 370 (6523), 1473-1479, 2020
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
DP Staus, RT Strachan, A Manglik, B Pani, AW Kahsai, TH Kim, ...
Nature 535 (7612), 448-452, 2016
Structural basis for nucleotide exchange in heterotrimeric G proteins
RO Dror, TJ Mildorf, D Hilger, A Manglik, DW Borhani, DH Arlow, ...
Science 348 (6241), 1361-1365, 2015
Test performance evaluation of SARS-CoV-2 serological assays
JD Whitman, J Hiatt, CT Mowery, BR Shy, R Yu, TN Yamamoto, U Rathore, ...
Nature biotechnology 38 (10), 1174, 2020
The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin
A Manglik, B Kobilka
Current opinion in cell biology 27, 136-143, 2014
Propagation of conformational changes during μ-opioid receptor activation
R Sounier, C Mas, J Steyaert, T Laeremans, A Manglik, W Huang, ...
Nature 524 (7565), 375-378, 2015
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