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Liang Chen
Liang Chen
BGI-research
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R-ChIP using inactive RNase H reveals dynamic coupling of R-loops with transcriptional pausing at gene promoters
L Chen#, JY Chen#, X Zhang, Y Gu, R Xiao, C Shao, P Tang, H Qian, ...
Molecular Cell 68 (4), 745-757. e5, 2017
3512017
GRID-seq reveals the global RNA–chromatin interactome
X Li, B Zhou, L Chen, LT Gou, H Li, XD Fu
Nature Biotechnology 35 (10), 940-950, 2017
2932017
The augmented R-loop is a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations
L Chen#, JY Chen#, YJ Huang#, Y Gu, J Qiu, H Qian, C Shao, X Zhang, ...
Molecular Cell 69 (3), 412-425. e6, 2018
2802018
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation
C Zhang, L Chen, D Peng, A Jiang, Y He, Y Zeng, C Xie, H Zhou, X Luo, ...
Molecular Cell 79 (3), 425-442. e7, 2020
2412020
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex
L Wang, Y Zhou, L Xu, R Xiao, X Lu, L Chen, J Chong, H Li, C He, XD Fu, ...
Nature 523 (7562), 621-625, 2015
1742015
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
X Wei#, S Fu#, H Li#*, Y Liu#, S Wang#, W Feng#, Y Yang#, X Liu, ...
Science 377 (6610), eabp9444, 2022
1492022
SRSF2 is essential for hematopoiesis, and its myelodysplastic syndrome-related mutations dysregulate alternative pre-mRNA splicing
Y Komeno, YJ Huang, J Qiu, L Lin, YJ Xu, Y Zhou, L Chen, ...
Molecular and Cellular Biology 35 (17), 3071-3082, 2015
1162015
RBFox2 binds nascent RNA to globally regulate polycomb complex 2 targeting in mammalian genomes
C Wei#, R Xiao#, L Chen#, H Cui#, Y Zhou#, Y Xue, J Hu, B Zhou, ...
Molecular Cell 62 (6), 875-889, 2016
1042016
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1
JY Chen, X Zhang, XD Fu*, L Chen*
Nature Protocols 14 (5), 1661-1685, 2019
712019
Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor
K Wang, H Wang, C Li, Z Yin, R Xiao, Q Li, Y Xiang, W Wang, J Huang, ...
Science advances 7 (8), eabe3516, 2021
692021
Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2
A Takatori, E Geh, L Chen, L Zhang, J Meller, Y Xia
Development 135 (1), 23-32, 2008
582008
Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators
J Qiu, B Zhou, F Thol, Y Zhou, L Chen, C Shao, C DeBoever, J Hou, H Li, ...
RNA 22 (10), 1535-1549, 2016
532016
Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis
H Li, X Wei, L Zhou, W Zhang, C Wang, Y Guo, D Li, J Chen, T Liu, ...
Protein & Cell, 1-10, 2020
492020
Inhibitor of ¥êB kinase ¥â regulates redox homeostasis by controlling the constitutive levels of glutathione
Z Peng, E Geh, L Chen, Q Meng, Y Fan, M Sartor, HG Shertzer, ZG Liu, ...
Molecular Pharmacology 77 (5), 784-792, 2010
492010
Complete nucleotide sequences and genome characterization of double-stranded RNA 1 and RNA 2 in the Raphanus sativus-root cv. Yipinghong
L Chen, JS Chen, L Liu, X Yu, S Yu, TZ Fu, WH Liu
Archives of Virology 151, 849-859, 2006
422006
Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater
T Wu, L Li, X Jiang, Y Yang, Y Song, L Chen, X Xu, Y Shen, Y Gu
Scientific reports 9 (1), 9514, 2019
412019
R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation
R Lin, X Zhong, Y Zhou, H Geng, Q Hu, Z Huang, J Hu, XD Fu, L Chen*, ...
Nucleic Acids Research, 2021
402021
Nuclear Factor-¥êB modulates cellular glutathione and prevents oxidative stress in cancer cells
Q Meng, Z Peng, L Chen, J Si, Z Dong, Y Xia
Cancer Letters 299 (1), 45-53, 2010
392010
Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation
L Chen, JL Ovesen, A Puga, Y Xia
Environmental Health Perspectives 117 (7), 1124-1130, 2009
382009
Complete nucleotide sequences of three dsRNA segments from Raphanus sativus-root cv. Yipinghong with leaf yellow edge symptoms
L Chen, JS Chen, H Zhang, SN Chen
Archives of Virology 151, 2077-2083, 2006
322006
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