R-ChIP using inactive RNase H reveals dynamic coupling of R-loops with transcriptional pausing at gene promoters L Chen#, JY Chen#, X Zhang, Y Gu, R Xiao, C Shao, P Tang, H Qian, ... Molecular Cell 68 (4), 745-757. e5, 2017 | 351 | 2017 |
GRID-seq reveals the global RNA–chromatin interactome X Li, B Zhou, L Chen, LT Gou, H Li, XD Fu Nature Biotechnology 35 (10), 940-950, 2017 | 293 | 2017 |
The augmented R-loop is a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations L Chen#, JY Chen#, YJ Huang#, Y Gu, J Qiu, H Qian, C Shao, X Zhang, ... Molecular Cell 69 (3), 412-425. e6, 2018 | 280 | 2018 |
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation C Zhang, L Chen, D Peng, A Jiang, Y He, Y Zeng, C Xie, H Zhou, X Luo, ... Molecular Cell 79 (3), 425-442. e7, 2020 | 241 | 2020 |
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex L Wang, Y Zhou, L Xu, R Xiao, X Lu, L Chen, J Chong, H Li, C He, XD Fu, ... Nature 523 (7562), 621-625, 2015 | 174 | 2015 |
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration X Wei#, S Fu#, H Li#*, Y Liu#, S Wang#, W Feng#, Y Yang#, X Liu, ... Science 377 (6610), eabp9444, 2022 | 149 | 2022 |
SRSF2 is essential for hematopoiesis, and its myelodysplastic syndrome-related mutations dysregulate alternative pre-mRNA splicing Y Komeno, YJ Huang, J Qiu, L Lin, YJ Xu, Y Zhou, L Chen, ... Molecular and Cellular Biology 35 (17), 3071-3082, 2015 | 116 | 2015 |
RBFox2 binds nascent RNA to globally regulate polycomb complex 2 targeting in mammalian genomes C Wei#, R Xiao#, L Chen#, H Cui#, Y Zhou#, Y Xue, J Hu, B Zhou, ... Molecular Cell 62 (6), 875-889, 2016 | 104 | 2016 |
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1 JY Chen, X Zhang, XD Fu*, L Chen* Nature Protocols 14 (5), 1661-1685, 2019 | 71 | 2019 |
Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor K Wang, H Wang, C Li, Z Yin, R Xiao, Q Li, Y Xiang, W Wang, J Huang, ... Science advances 7 (8), eabe3516, 2021 | 69 | 2021 |
Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2 A Takatori, E Geh, L Chen, L Zhang, J Meller, Y Xia Development 135 (1), 23-32, 2008 | 58 | 2008 |
Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators J Qiu, B Zhou, F Thol, Y Zhou, L Chen, C Shao, C DeBoever, J Hou, H Li, ... RNA 22 (10), 1535-1549, 2016 | 53 | 2016 |
Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis H Li, X Wei, L Zhou, W Zhang, C Wang, Y Guo, D Li, J Chen, T Liu, ... Protein & Cell, 1-10, 2020 | 49 | 2020 |
Inhibitor of ¥êB kinase ¥â regulates redox homeostasis by controlling the constitutive levels of glutathione Z Peng, E Geh, L Chen, Q Meng, Y Fan, M Sartor, HG Shertzer, ZG Liu, ... Molecular Pharmacology 77 (5), 784-792, 2010 | 49 | 2010 |
Complete nucleotide sequences and genome characterization of double-stranded RNA 1 and RNA 2 in the Raphanus sativus-root cv. Yipinghong L Chen, JS Chen, L Liu, X Yu, S Yu, TZ Fu, WH Liu Archives of Virology 151, 849-859, 2006 | 42 | 2006 |
Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater T Wu, L Li, X Jiang, Y Yang, Y Song, L Chen, X Xu, Y Shen, Y Gu Scientific reports 9 (1), 9514, 2019 | 41 | 2019 |
R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation R Lin, X Zhong, Y Zhou, H Geng, Q Hu, Z Huang, J Hu, XD Fu, L Chen*, ... Nucleic Acids Research, 2021 | 40 | 2021 |
Nuclear Factor-¥êB modulates cellular glutathione and prevents oxidative stress in cancer cells Q Meng, Z Peng, L Chen, J Si, Z Dong, Y Xia Cancer Letters 299 (1), 45-53, 2010 | 39 | 2010 |
Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation L Chen, JL Ovesen, A Puga, Y Xia Environmental Health Perspectives 117 (7), 1124-1130, 2009 | 38 | 2009 |
Complete nucleotide sequences of three dsRNA segments from Raphanus sativus-root cv. Yipinghong with leaf yellow edge symptoms L Chen, JS Chen, H Zhang, SN Chen Archives of Virology 151, 2077-2083, 2006 | 32 | 2006 |