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Nico Marr
Nico Marr
Investigator and Group Leader, Sidra Medicine
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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ...
Science 370 (6515), eabd4570, 2020
13922020
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
N Hernandez, I Melki, H Jing, T Habib, SSY Huang, J Danielson, T Kula, ...
The Journal of experimental medicine 215 (10), 2567-2585, 2018
1252018
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ...
Science immunology 6 (62), eabl4348, 2021
1192021
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
V Béziat, J Li, JX Lin, CS Ma, P Li, A Bousfiha, I Pellier, S Zoghi, S Baris, ...
Science immunology 3 (24), eaat4956, 2018
1132018
Combined immunodeficiency associated with homozygous MALT1 mutations
ML McKinnon, J Rozmus, SY Fung, AF Hirschfeld, KL Del Bel, L Thomas, ...
Journal of allergy and clinical immunology 133 (5), 1458-1462. e7, 2014
1062014
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant
S Boisson-Dupuis, N Ramirez-Alejo, Z Li, E Patin, G Rao, G Kerner, ...
Science immunology 3 (30), eaau8714, 2018
1022018
Attenuation of respiratory syncytial virus–induced and RIG-I–dependent type I IFN responses in human neonates and very young children
N Marr, TI Wang, SHY Kam, YS Hu, AA Sharma, A Lam, J Markowski, ...
The Journal of Immunology 192 (3), 948-957, 2014
1012014
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
N Hernandez, G Bucciol, L Moens, J Le Pen, M Shahrooei, E Goudouris, ...
Journal of Experimental Medicine 216 (9), 2057-2070, 2019
992019
Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication
N Marr, SE Turvey
Innate immunity 18 (6), 856-865, 2012
892012
Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia
S Ali, AF Hirschfeld, ML Mayer, ES Fortuno, N Corbett, M Kaplan, S Wang, ...
The Journal of Immunology 190 (8), 3949-3958, 2013
882013
Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance
N Marr, NR Shah, R Lee, EJ Kim, RC Fernandez
PloS one 6 (6), e20585, 2011
682011
Glucosamine Found as a Substituent of Both Phosphate Groups in Bordetella Lipid A Backbones: Role of a BvgAS-Activated ArnT Ortholog
N Marr, A Tirsoaga, D Blanot, R Fernandez, M Caroff
Journal of bacteriology 190 (12), 4281-4290, 2008
662008
Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model
N Marr, DC Oliver, V Laurent, J Poolman, P Denoël, RC Fernandez
Vaccine 26 (34), 4306-4311, 2008
652008
Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF-κB Activation and Release of Proinflammatory …
N Marr, AM Hajjar, NR Shah, A Novikov, CS Yam, M Caroff, ...
Infection and immunity 78 (5), 2060-2069, 2010
512010
IL‐4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates
D You, N Marr, J Saravia, B Shrestha, GI Lee, SE Turvey, F Brombacher, ...
Journal of leukocyte biology 93 (6), 933-942, 2013
502013
Inherited human IFN-γ deficiency underlies mycobacterial disease
G Kerner, J Rosain, A Guérin, A Al-Khabaz, C Oleaga-Quintas, ...
The Journal of clinical investigation 130 (6), 3158-3171, 2020
492020
Respiratory syncytial virus infection of primary human mast cells induces the selective production of type I interferons, CXCL10, and CCL4
A Al-Afif, R Alyazidi, SA Oldford, YY Huang, CA King, N Marr, ID Haidl, ...
Journal of Allergy and Clinical Immunology 136 (5), 1346-1354. e1, 2015
482015
Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts
E Della Mina, A Borghesi, H Zhou, S Bougarn, S Boughorbel, L Israel, ...
Proceedings of the National Academy of Sciences 114 (4), E514-E523, 2017
472017
Minor modifications to the phosphate groups and the C3′ acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like …
NR Shah, S AlBitar-Nehme, E Kim, N Marr, A Novikov, M Caroff, ...
Journal of Biological Chemistry 288 (17), 11751-11760, 2013
472013
IRF4 haploinsufficiency in a family with Whipple’s disease
A Guérin, G Kerner, N Marr, JG Markle, F Fenollar, N Wong, S Boughorbel, ...
Elife 7, e32340, 2018
452018
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