| Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ... Science 370 (6515), eabd4570, 2020 | 1392 | 2020 |
| Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency N Hernandez, I Melki, H Jing, T Habib, SSY Huang, J Danielson, T Kula, ... The Journal of experimental medicine 215 (10), 2567-2585, 2018 | 125 | 2018 |
| X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19 T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ... Science immunology 6 (62), eabl4348, 2021 | 119 | 2021 |
| A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity V Béziat, J Li, JX Lin, CS Ma, P Li, A Bousfiha, I Pellier, S Zoghi, S Baris, ... Science immunology 3 (24), eaat4956, 2018 | 113 | 2018 |
| Combined immunodeficiency associated with homozygous MALT1 mutations ML McKinnon, J Rozmus, SY Fung, AF Hirschfeld, KL Del Bel, L Thomas, ... Journal of allergy and clinical immunology 133 (5), 1458-1462. e7, 2014 | 106 | 2014 |
| Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant S Boisson-Dupuis, N Ramirez-Alejo, Z Li, E Patin, G Rao, G Kerner, ... Science immunology 3 (30), eaau8714, 2018 | 102 | 2018 |
| Attenuation of respiratory syncytial virus–induced and RIG-I–dependent type I IFN responses in human neonates and very young children N Marr, TI Wang, SHY Kam, YS Hu, AA Sharma, A Lam, J Markowski, ... The Journal of Immunology 192 (3), 948-957, 2014 | 101 | 2014 |
| Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines N Hernandez, G Bucciol, L Moens, J Le Pen, M Shahrooei, E Goudouris, ... Journal of Experimental Medicine 216 (9), 2057-2070, 2019 | 99 | 2019 |
| Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication N Marr, SE Turvey Innate immunity 18 (6), 856-865, 2012 | 89 | 2012 |
| Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia S Ali, AF Hirschfeld, ML Mayer, ES Fortuno, N Corbett, M Kaplan, S Wang, ... The Journal of Immunology 190 (8), 3949-3958, 2013 | 88 | 2013 |
| Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance N Marr, NR Shah, R Lee, EJ Kim, RC Fernandez PloS one 6 (6), e20585, 2011 | 68 | 2011 |
| Glucosamine Found as a Substituent of Both Phosphate Groups in Bordetella Lipid A Backbones: Role of a BvgAS-Activated ArnT Ortholog N Marr, A Tirsoaga, D Blanot, R Fernandez, M Caroff Journal of bacteriology 190 (12), 4281-4290, 2008 | 66 | 2008 |
| Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model N Marr, DC Oliver, V Laurent, J Poolman, P Denoël, RC Fernandez Vaccine 26 (34), 4306-4311, 2008 | 65 | 2008 |
| Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF-κB Activation and Release of Proinflammatory … N Marr, AM Hajjar, NR Shah, A Novikov, CS Yam, M Caroff, ... Infection and immunity 78 (5), 2060-2069, 2010 | 51 | 2010 |
| IL‐4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates D You, N Marr, J Saravia, B Shrestha, GI Lee, SE Turvey, F Brombacher, ... Journal of leukocyte biology 93 (6), 933-942, 2013 | 50 | 2013 |
| Inherited human IFN-γ deficiency underlies mycobacterial disease G Kerner, J Rosain, A Guérin, A Al-Khabaz, C Oleaga-Quintas, ... The Journal of clinical investigation 130 (6), 3158-3171, 2020 | 49 | 2020 |
| Respiratory syncytial virus infection of primary human mast cells induces the selective production of type I interferons, CXCL10, and CCL4 A Al-Afif, R Alyazidi, SA Oldford, YY Huang, CA King, N Marr, ID Haidl, ... Journal of Allergy and Clinical Immunology 136 (5), 1346-1354. e1, 2015 | 48 | 2015 |
| Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts E Della Mina, A Borghesi, H Zhou, S Bougarn, S Boughorbel, L Israel, ... Proceedings of the National Academy of Sciences 114 (4), E514-E523, 2017 | 47 | 2017 |
| Minor modifications to the phosphate groups and the C3′ acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like … NR Shah, S AlBitar-Nehme, E Kim, N Marr, A Novikov, M Caroff, ... Journal of Biological Chemistry 288 (17), 11751-11760, 2013 | 47 | 2013 |
| IRF4 haploinsufficiency in a family with Whipple’s disease A Guérin, G Kerner, N Marr, JG Markle, F Fenollar, N Wong, S Boughorbel, ... Elife 7, e32340, 2018 | 45 | 2018 |
