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James A Roper
James A Roper
Galecto Biotech
Verified email at galecto.com
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Year
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues
GGJ Hazell, ST Yao, JA Roper, ER Prossnitz, AM O'Carroll, SJ Lolait
The Journal of endocrinology 202 (2), 223, 2009
4132009
Emerging therapeutic opportunities for integrin inhibitors
RJ Slack, SJF Macdonald, JA Roper, RG Jenkins, RJD Hatley
Nature Reviews Drug Discovery 21 (1), 60-78, 2022
2352022
The vasopressin Avpr1b receptor: molecular and pharmacological studies
JA Roper, AM O'carroll, WS Young III, SJ Lolait
Stress 14 (1), 98-115, 2011
1282011
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei–serpentine gateways to neuroendocrine homeostasis
GGJ Hazell, CC Hindmarch, GR Pope, JA Roper, SL Lightman, D Murphy, ...
Frontiers in neuroendocrinology 33 (1), 45-66, 2012
902012
Syndecan and integrin interactomes: large complexes in small spaces
JA Roper, RC Williamson, MD Bass
Current opinion in structural biology 22 (5), 583-590, 2012
872012
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
AE John, RH Graves, KT Pun, G Vitulli, EJ Forty, PF Mercer, JL Morrell, ...
Nature Communications 11 (1), 4659, 2020
742020
Pituitary‐adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
LQ Stewart, JA Roper, WS Young Iii, AM O’Carroll, SJ Lolait
Journal of neuroendocrinology 20 (5), 597-605, 2008
692008
Attenuated stress response to acute lipopolysaccharide challenge and ethanol administration in vasopressin V1b receptor knockout mice
SJ Lolait, LQ Stewart, JA Roper, G Harrison, DS Jessop, WS Young III, ...
Journal of neuroendocrinology 19 (7), 543-551, 2007
522007
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure
RC Williamson, CAM Cowell, CL Hammond, DJM Bergen, JA Roper, ...
Journal of cell science 127 (19), 4292-4307, 2014
492014
Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats
G Delaney, KL Dawe, R Hogan, T Hunjan, J Roper, G Hazell, SJ Lolait, ...
Journal of neuroendocrinology 24 (12), 1527-1541, 2012
482012
The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants
LQ Stewart, JA Roper, WS Young III, AM O’Carroll, SJ Lolait
Psychoneuroendocrinology 33 (4), 405-415, 2008
462008
Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1
JA Roper, RC Williamson, B Bally, CAM Cowell, R Brooks, P Stephens, ...
Journal of Investigative Dermatology 135 (11), 2842-2851, 2015
412015
Integrins as a drug target in liver fibrosis
SR Rahman, JA Roper, JI Grove, GP Aithal, KT Pun, AJ Bennett
Liver International 42 (3), 507-521, 2022
352022
Attenuated stress response to acute restraint and forced swimming stress in arginine vasopressin 1b receptor subtype (Avpr1b) receptor knockout mice and wild‐type mice treated …
JA Roper, M Craighead, AM O’Carroll, SJ Lolait
Journal of neuroendocrinology 22 (11), 1173-1180, 2010
342010
Discovery and optimization of the first highly effective and orally available galectin-3 inhibitors for treatment of fibrotic disease
FR Zetterberg, A MacKinnon, T Brimert, L Gravelle, RE Johnsson, ...
Journal of Medicinal Chemistry 65 (19), 12626-12638, 2022
302022
Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
ME Barbour, SE Maddocks, HJ Grady, JA Roper, MD Bass, AM Collins, ...
Nanomedicine 11 (16), 2049-2057, 2016
282016
Induction of adhesion-dependent signals using low-intensity ultrasound
J Roper, A Harrison, MD Bass
JoVE (Journal of Visualized Experiments), e4024, 2012
242012
Coronin-1C protein and caveolin protein provide constitutive and inducible mechanisms of Rac1 protein trafficking
RC Williamson, CAM Cowell, T Reville, JA Roper, TCS Rendall, MD Bass
Journal of Biological Chemistry 290 (25), 15437-15449, 2015
172015
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor—(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1 …
TN Barrett, JA Taylor, D Barker, PA Procopiou, JDF Thompson, J Barrett, ...
Journal of Medicinal Chemistry 62 (16), 7543-7556, 2019
72019
Neuropeptide receptors
SJ Lolait, JA Roper, GGJ Hazell, Y Li, FJ Thomson, AM O'Carroll
Molecular Neuroendocrinology: From Genome to Physiology, 195-215, 2016
72016
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