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Paola Bisignano
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Multitarget drug discovery for Alzheimer's disease: triazinones as BACE‐1 and GSK‐3β inhibitors
F Prati, A De Simone, P Bisignano, A Armirotti, M Summa, D Pizzirani, ...
Angewandte Chemie 127 (5), 1598-1602, 2015
1212015
Versatility of the curcumin scaffold: discovery of potent and balanced dual BACE-1 and GSK-3β inhibitors
RMC Di Martino, A De Simone, V Andrisano, P Bisignano, A Bisi, S Gobbi, ...
Journal of medicinal chemistry 59 (2), 531-544, 2016
932016
Cilia-associated oxysterols activate smoothened
DR Raleigh, N Sever, PK Choksi, MA Sigg, KM Hines, BM Thompson, ...
Molecular cell 72 (2), 316-327. e5, 2018
852018
Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions
Y Shang, V LeRouzic, S Schneider, P Bisignano, GW Pasternak, ...
Biochemistry 53 (31), 5140-5149, 2014
792014
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
WY Wahlgren, E Dunevall, RA North, A Paz, M Scalise, P Bisignano, ...
Nature Communications 9 (1), 1-14, 2018
592018
Stochastic steps in secondary active sugar transport
JL Adelman, C Ghezzi, P Bisignano, DDF Loo, S Choe, J Abramson, ...
Proceedings of the National Academy of Sciences 113 (27), E3960-E3966, 2016
392016
Ligand-based discovery of a new scaffold for allosteric modulation of the μ-opioid receptor
P Bisignano, NT Burford, Y Shang, B Marlow, KE Livingston, AM Fenton, ...
Journal of chemical information and modeling 55 (9), 1836-1843, 2015
342015
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
P Bisignano, C Ghezzi, H Jo, NF Polizzi, T Althoff, C Kalyanaraman, ...
Nature communications 9 (1), 1-10, 2018
292018
Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1
LA Bergdoll, MT Lerch, JW Patrick, K Belardo, C Altenbach, P Bisignano, ...
Proceedings of the National Academy of Sciences 115 (2), E172-E179, 2018
232018
Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake
JH Wardman, I Gomes, EN Bobeck, JA Stockert, A Kapoor, P Bisignano, ...
Science signaling 9 (430), ra55-ra55, 2016
232016
Kinetic characterization of fragment binding in AmpC β-lactamase by high-throughput molecular simulations
P Bisignano, S Doerr, MJ Harvey, AD Favia, A Cavalli, G De Fabritiis
Journal of Chemical Information and Modeling 54 (2), 362-366, 2014
232014
Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR–nucleotide binding domain 1
P Bisignano, O Moran
Biochimie 92 (1), 51-57, 2010
232010
Conformational transitions of the sodium-dependent sugar transporter, vSGLT
A Paz, DP Claxton, JP Kumar, K Kazmier, P Bisignano, S Sharma, ...
Proceedings of the National Academy of Sciences 115 (12), E2742-E2751, 2018
222018
SERAPhiC: a benchmark for in silico fragment-based drug design
AD Favia, G Bottegoni, I Nobeli, P Bisignano, A Cavalli
Journal of chemical information and modeling 51 (11), 2882-2896, 2011
212011
A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition
S Redenti, I Marcovich, T De Vita, C Pérez, R De Zorzi, N Demitri, ...
ChemMedChem 14 (3), 310-314, 2019
182019
Development and application of a virtual screening protocol for the identification of multitarget fragments
G Bottegoni, M Veronesi, P Bisignano, P Kacker, AD Favia, A Cavalli
ChemMedChem 11 (12), 1259-1263, 2016
182016
PLI: a web-based tool for the comparison of protein-ligand interactions observed on PDB structures
AM Gallina, P Bisignano, M Bergamino, D Bordo
Bioinformatics 29 (3), 395-397, 2013
172013
A kinetic mechanism for enhanced selectivity of membrane transport
P Bisignano, MA Lee, A George, DM Zuckerman, M Grabe, JM Rosenberg
PLoS computational biology 16 (7), e1007789, 2020
92020
A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms
A George, P Bisignano, JM Rosenberg, M Grabe, DM Zuckerman
PLoS computational biology 16 (7), e1007884, 2020
62020
In silico deconstruction of ATP-competitive inhibitors of glycogen synthase kinase-3β
P Bisignano, C Lambruschini, M Bicego, V Murino, AD Favia, A Cavalli
Journal of chemical information and modeling 52 (12), 3233-3244, 2012
62012
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Articles 1–20