Bioorganometallic mechanism of action, and inhibition, of IspH W Wang, K Wang, YL Liu, JH No, J Li, MJ Nilges, E Oldfield Proceedings of the National Academy of Sciences 107 (10), 4522-4527, 2010 | 100 | 2010 |
Coupling oxygen consumption with hydrocarbon oxidation in bacterial multicomponent monooxygenases W Wang, AD Liang, SJ Lippard Accounts of chemical research 48 (9), 2632-2639, 2015 | 85 | 2015 |
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG) W Wang, J Li, K Wang, C Huang, Y Zhang, E Oldfield Proceedings of the National Academy of Sciences 107 (25), 11189-11193, 2010 | 77 | 2010 |
Inhibition of the Fe4S4-Cluster-Containing Protein IspH (LytB): Electron Paramagnetic Resonance, Metallacycles, and Mechanisms K Wang, W Wang, JH No, Y Zhang, Y Zhang, E Oldfield Journal of the American Chemical Society 132 (19), 6719-6727, 2010 | 74 | 2010 |
Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis W Wang, E Oldfield Angewandte Chemie International Edition 53 (17), 4294-4310, 2014 | 59 | 2014 |
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation W Wang, K Wang, I Span, J Jauch, A Bacher, M Groll, E Oldfield Journal of the American Chemical Society 134 (27), 11225-11234, 2012 | 52 | 2012 |
Discovery of acetylene hydratase activity of the iron–sulphur protein IspH I Span, K Wang, W Wang, Y Zhang, A Bacher, W Eisenreich, K Li, ... Nature communications 3 (1), 1042, 2012 | 47 | 2012 |
Pyridine Inhibitor Binding to the 4Fe-4S Protein A. aeolicus IspH (LytB): A HYSCORE Investigation W Wang, J Li, K Wang, TI Smirnova, E Oldfield Journal of the American Chemical Society 133 (17), 6525-6528, 2011 | 42 | 2011 |
Electron transfer control in soluble methane monooxygenase W Wang, RE Iacob, RP Luoh, JR Engen, SJ Lippard Journal of the American Chemical Society 136 (27), 9754-9762, 2014 | 41 | 2014 |
Diiron oxidation state control of substrate access to the active site of soluble methane monooxygenase mediated by the regulatory component W Wang, SJ Lippard Journal of the American Chemical Society 136 (6), 2244-2247, 2014 | 41 | 2014 |
Structure, function and inhibition of the two-and three-domain 4Fe-4S IspG proteins YL Liu, F Guerra, K Wang, W Wang, J Li, C Huang, W Zhu, K Houlihan, ... Proceedings of the National Academy of Sciences 109 (22), 8558-8563, 2012 | 38 | 2012 |
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis W Wang, K Wang, J Li, S Nellutla, TI Smirnova, E Oldfield Journal of the American Chemical Society 133 (22), 8400-8403, 2011 | 37 | 2011 |
Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH I Span, K Wang, W Wang, J Jauch, W Eisenreich, A Bacher, E Oldfield, ... Angewandte Chemie International Edition 52 (7), 2118-2121, 2013 | 31 | 2013 |
Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt (II) cage YR Zheng, K Suntharalingam, PM Bruno, W Lin, W Wang, MT Hemann, ... Inorganica chimica acta 452, 125-129, 2016 | 27 | 2016 |
Inhibition of the 4Fe–4S proteins IspG and IspH: an EPR, ENDOR and HYSCORE investigation F Guerra, K Wang, J Li, W Wang, YL Liu, S Amin, E Oldfield Chemical Science 5 (4), 1642-1649, 2014 | 21 | 2014 |
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay W Wang, L Mevellec, A Liu, G Struble, R Miller, SJ Allen, K Federowicz, ... Biochemistry 60 (41), 3114-3124, 2021 | 11 | 2021 |
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non‐diphosphate Inhibitors B O'Dowd, S Williams, H Wang, JH No, G Rao, W Wang, JA McCammon, ... ChemBioChem 18 (10), 914-920, 2017 | 10 | 2017 |
Discovery of a potent and selective covalent inhibitor of Bruton’s tyrosine kinase with oral anti-inflammatory activity MS Tichenor, JJM Wiener, NL Rao, C Pooley Deckhut, JK Barbay, ... ACS Medicinal Chemistry Letters 12 (5), 782-790, 2021 | 9 | 2021 |
Fluor‐, Amino‐und Thiolinhibitoren im Komplex mit dem [Fe4S4]‐Protein IspH I Span, K Wang, W Wang, J Jauch, W Eisenreich, A Bacher, E Oldfield, ... Angewandte Chemie 125 (7), 2172-2175, 2013 | 9 | 2013 |
STX-478, a mutant-selective, allosteric PI3Kα inhibitor spares metabolic dysfunction and improves therapeutic response in PI3Kα-mutant xenografts L Buckbinder, DJ St. Jean Jr, T Tieu, B Ladd, B Hilbert, W Wang, ... Cancer Discovery 13 (11), 2432-2447, 2023 | 8 | 2023 |