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Weixue Wang
Weixue Wang
Scorpion Therapeutics
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Cited by
Year
Bioorganometallic mechanism of action, and inhibition, of IspH
W Wang, K Wang, YL Liu, JH No, J Li, MJ Nilges, E Oldfield
Proceedings of the National Academy of Sciences 107 (10), 4522-4527, 2010
1002010
Coupling oxygen consumption with hydrocarbon oxidation in bacterial multicomponent monooxygenases
W Wang, AD Liang, SJ Lippard
Accounts of chemical research 48 (9), 2632-2639, 2015
852015
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)
W Wang, J Li, K Wang, C Huang, Y Zhang, E Oldfield
Proceedings of the National Academy of Sciences 107 (25), 11189-11193, 2010
772010
Inhibition of the Fe4S4-Cluster-Containing Protein IspH (LytB): Electron Paramagnetic Resonance, Metallacycles, and Mechanisms
K Wang, W Wang, JH No, Y Zhang, Y Zhang, E Oldfield
Journal of the American Chemical Society 132 (19), 6719-6727, 2010
742010
Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis
W Wang, E Oldfield
Angewandte Chemie International Edition 53 (17), 4294-4310, 2014
592014
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation
W Wang, K Wang, I Span, J Jauch, A Bacher, M Groll, E Oldfield
Journal of the American Chemical Society 134 (27), 11225-11234, 2012
522012
Discovery of acetylene hydratase activity of the iron–sulphur protein IspH
I Span, K Wang, W Wang, Y Zhang, A Bacher, W Eisenreich, K Li, ...
Nature communications 3 (1), 1042, 2012
472012
Pyridine Inhibitor Binding to the 4Fe-4S Protein A. aeolicus IspH (LytB): A HYSCORE Investigation
W Wang, J Li, K Wang, TI Smirnova, E Oldfield
Journal of the American Chemical Society 133 (17), 6525-6528, 2011
422011
Electron transfer control in soluble methane monooxygenase
W Wang, RE Iacob, RP Luoh, JR Engen, SJ Lippard
Journal of the American Chemical Society 136 (27), 9754-9762, 2014
412014
Diiron oxidation state control of substrate access to the active site of soluble methane monooxygenase mediated by the regulatory component
W Wang, SJ Lippard
Journal of the American Chemical Society 136 (6), 2244-2247, 2014
412014
Structure, function and inhibition of the two-and three-domain 4Fe-4S IspG proteins
YL Liu, F Guerra, K Wang, W Wang, J Li, C Huang, W Zhu, K Houlihan, ...
Proceedings of the National Academy of Sciences 109 (22), 8558-8563, 2012
382012
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis
W Wang, K Wang, J Li, S Nellutla, TI Smirnova, E Oldfield
Journal of the American Chemical Society 133 (22), 8400-8403, 2011
372011
Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH
I Span, K Wang, W Wang, J Jauch, W Eisenreich, A Bacher, E Oldfield, ...
Angewandte Chemie International Edition 52 (7), 2118-2121, 2013
312013
Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt (II) cage
YR Zheng, K Suntharalingam, PM Bruno, W Lin, W Wang, MT Hemann, ...
Inorganica chimica acta 452, 125-129, 2016
272016
Inhibition of the 4Fe–4S proteins IspG and IspH: an EPR, ENDOR and HYSCORE investigation
F Guerra, K Wang, J Li, W Wang, YL Liu, S Amin, E Oldfield
Chemical Science 5 (4), 1642-1649, 2014
212014
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay
W Wang, L Mevellec, A Liu, G Struble, R Miller, SJ Allen, K Federowicz, ...
Biochemistry 60 (41), 3114-3124, 2021
112021
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non‐diphosphate Inhibitors
B O'Dowd, S Williams, H Wang, JH No, G Rao, W Wang, JA McCammon, ...
ChemBioChem 18 (10), 914-920, 2017
102017
Discovery of a potent and selective covalent inhibitor of Bruton’s tyrosine kinase with oral anti-inflammatory activity
MS Tichenor, JJM Wiener, NL Rao, C Pooley Deckhut, JK Barbay, ...
ACS Medicinal Chemistry Letters 12 (5), 782-790, 2021
92021
Fluor‐, Amino‐und Thiolinhibitoren im Komplex mit dem [Fe4S4]‐Protein IspH
I Span, K Wang, W Wang, J Jauch, W Eisenreich, A Bacher, E Oldfield, ...
Angewandte Chemie 125 (7), 2172-2175, 2013
92013
STX-478, a mutant-selective, allosteric PI3Kα inhibitor spares metabolic dysfunction and improves therapeutic response in PI3Kα-mutant xenografts
L Buckbinder, DJ St. Jean Jr, T Tieu, B Ladd, B Hilbert, W Wang, ...
Cancer Discovery 13 (11), 2432-2447, 2023
82023
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