| The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism JA Engelman, J Luo, LC Cantley Nature Reviews Genetics 7 (8), 606-619, 2006 | 3905 | 2006 |
| Principles of cancer therapy: oncogene and non-oncogene addiction J Luo, NL Solimini, SJ Elledge Cell 136 (5), 823-837, 2009 | 2202 | 2009 |
| Drugging the undruggable RAS: Mission possible? AD Cox, SW Fesik, AC Kimmelman, J Luo, CJ Der Nature reviews Drug discovery 13 (11), 828-851, 2014 | 1945 | 2014 |
| Targeting the PI3K-Akt pathway in human cancer: rationale and promise J Luo, BD Manning, LC Cantley Cancer cell 4 (4), 257-262, 2003 | 1670 | 2003 |
| A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene J Luo, MJ Emanuele, D Li, CJ Creighton, MR Schlabach, TF Westbrook, ... Cell 137 (5), 835-848, 2009 | 1154 | 2009 |
| Breast cancer–associated PIK3CA mutations are oncogenic in mammary epithelial cells SJ Isakoff, JA Engelman, HY Irie, J Luo, SM Brachmann, RV Pearline, ... Cancer research 65 (23), 10992-11000, 2005 | 589 | 2005 |
| Cancer proliferation gene discovery through functional genomics MR Schlabach, J Luo, NL Solimini, G Hu, Q Xu, MZ Li, Z Zhao, ... Science 319 (5863), 620-624, 2008 | 462 | 2008 |
| Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice JW Hill, KW Williams, C Ye, J Luo, N Balthasar, R Coppari, MA Cowley, ... The Journal of clinical investigation 118 (5), 1796-1805, 2008 | 381 | 2008 |
| Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ CM Taniguchi, T Kondo, M Sajan, J Luo, R Bronson, T Asano, R Farese, ... Cell metabolism 3 (5), 343-353, 2006 | 328 | 2006 |
| Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy J Luo, JR McMullen, CL Sobkiw, L Zhang, AL Dorfman, MC Sherwood, ... Molecular and cellular biology 25 (21), 9491-9502, 2005 | 255 | 2005 |
| The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex J Luo, SJ Field, JY Lee, JA Engelman, LC Cantley The Journal of cell biology 170 (3), 455-464, 2005 | 210 | 2005 |
| Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN CM Taniguchi, TT Tran, T Kondo, J Luo, K Ueki, LC Cantley, CR Kahn Proceedings of the National Academy of Sciences 103 (32), 12093-12097, 2006 | 191 | 2006 |
| The phosphoinositide 3-kinase regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signaling CM Taniguchi, J Winnay, T Kondo, RT Bronson, AR Guimaraes, ... Cancer research 70 (13), 5305-5315, 2010 | 164 | 2010 |
| Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia J Luo, CL Sobkiw, MF Hirshman, MN Logsdon, TQ Li, LJ Goodyear, ... Cell metabolism 3 (5), 355-366, 2006 | 150 | 2006 |
| Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis JD Chang, GK Sukhova, P Libby, E Schvartz, AH Lichtenstein, SJ Field, ... Proceedings of the National Academy of Sciences 104 (19), 8077-8082, 2007 | 128 | 2007 |
| Then negative regulation of phosphoinositide 3-kinase signaling by p85 and its implication in cancer JI Luo, LC Cantley Cell cycle 4 (10), 1309-1312, 2005 | 127 | 2005 |
| Development of siRNA Payloads to Target KRAS-Mutant Cancer TL Yuan, C Fellmann, CS Lee, CD Ritchie, V Thapar, LC Lee, DJ Hsu, ... Cancer discovery 4 (10), 1182-1197, 2014 | 122 | 2014 |
| Class 1A PI3K regulates vessel integrity during development and tumorigenesis TL Yuan, HS Choi, A Matsui, C Benes, E Lifshits, J Luo, JV Frangioni, ... Proceedings of the National Academy of Sciences 105 (28), 9739-9744, 2008 | 120 | 2008 |
| Differential effector engagement by oncogenic KRAS TL Yuan, A Amzallag, R Bagni, M Yi, S Afghani, W Burgan, N Fer, ... Cell reports 22 (7), 1889-1902, 2018 | 116 | 2018 |
| The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance CM Taniguchi, JO Aleman, K Ueki, J Luo, T Asano, H Kaneto, ... Molecular and cellular biology 27 (8), 2830-2840, 2007 | 101 | 2007 |
