An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 RC Doebele, LE Davis, A Vaishnavi, AT Le, A Estrada-Bernal, S Keysar, ... Cancer discovery 5 (10), 1049-1057, 2015 | 410* | 2015 |
More than markers: biological significance of cancer stem cell-defining molecules SB Keysar, A Jimeno Molecular cancer therapeutics 9 (9), 2450-2457, 2010 | 250 | 2010 |
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins SB Keysar, DP Astling, RT Anderson, BW Vogler, DW Bowles, JJ Morton, ... Molecular oncology 7 (4), 776-790, 2013 | 171 | 2013 |
XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer JJ Morton, G Bird, SB Keysar, DP Astling, TR Lyons, RT Anderson, ... Oncogene 35 (3), 290-300, 2016 | 134 | 2016 |
Cancer cell CD44 mediates macrophage/monocyte-driven regulation of head and neck cancer stem cells KE Gomez, FL Wu, SB Keysar, JJ Morton, B Miller, TS Chimed, PN Le, ... Cancer research 80 (19), 4185-4198, 2020 | 122 | 2020 |
Regulation of head and neck squamous cancer stem cells by PI3K and SOX2 SB Keysar, PN Le, B Miller, BC Jackson, JR Eagles, C Nieto, J Kim, ... Journal of the National Cancer Institute 109 (1), djw189, 2017 | 121 | 2017 |
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis RA White, JM Neiman, A Reddi, G Han, S Birlea, D Mitra, L Dionne, ... The Journal of clinical investigation 123 (10), 4390-4404, 2013 | 104 | 2013 |
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer SB Keysar, PN Le, RT Anderson, JJ Morton, DW Bowles, JJ Paylor, ... Cancer research 73 (11), 3381-3392, 2013 | 104 | 2013 |
EGFR mediates responses to small-molecule drugs targeting oncogenic fusion kinases A Vaishnavi, L Schubert, U Rix, LA Marek, AT Le, SB Keysar, ... Cancer research 77 (13), 3551-3563, 2017 | 77 | 2017 |
Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers GN Gan, J Eagles, SB Keysar, G Wang, MJ Glogowska, C Altunbas, ... Cancer research 74 (23), 7024-7036, 2014 | 74 | 2014 |
Phase I study of oral rigosertib (ON 01910. Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies DW Bowles, JR Diamond, ET Lam, CD Weekes, DP Astling, RT Anderson, ... Clinical Cancer Research 20 (6), 1656-1665, 2014 | 70 | 2014 |
Wnt signaling dynamics in head and neck squamous cell cancer tumor‐stroma interactions PN Le, SB Keysar, B Miller, JR Eagles, TS Chimed, J Reisinger, ... Molecular carcinogenesis 58 (3), 398-410, 2019 | 56 | 2019 |
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer JJ Arcaroli, WM Tai, R McWilliams, S Bagby, PJ Blatchford, ... International journal of cancer 138 (1), 195-205, 2016 | 45 | 2016 |
A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma DW Bowles, SB Keysar, JR Eagles, G Wang, MJ Glogowska, ... Oral oncology 53, 74-79, 2016 | 40 | 2016 |
The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas RT Anderson, SB Keysar, DW Bowles, MJ Glogowska, DP Astling, ... Molecular cancer therapeutics 12 (10), 1994-2005, 2013 | 36 | 2013 |
Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene events associated with tumor progression SB Keysar, JR Eagles, B Miller, BC Jackson, FN Chowdhury, J Reisinger, ... Clinical Cancer Research 24 (12), 2935-2943, 2018 | 30 | 2018 |
Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay CT French, CD Ross, SB Keysar, DD Joshi, CU Lim, MH Fox Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 602 (1 …, 2006 | 30 | 2006 |
Inter‐ and intra‐tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas AL Hernandez, Y Wang, HL Somerset, SB Keysar, DL Aisner, C Marshall, ... Molecular carcinogenesis 58 (5), 666-673, 2019 | 26 | 2019 |
Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer JJ Morton, SB Keysar, L Perrenoud, TS Chimed, J Reisinger, B Jackson, ... Molecular carcinogenesis 57 (11), 1651-1663, 2018 | 22 | 2018 |
DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation CP Allen, W Tinganelli, N Sharma, J Nie, C Sicard, F Natale, M King III, ... Frontiers in oncology 5, 260, 2015 | 22 | 2015 |