| Epithelial sodium channels are activated by furin-dependent proteolysis RP Hughey, JB Bruns, CL Kinlough, KL Harkleroad, Q Tong, ... Journal of Biological Chemistry 279 (18), 18111-18114, 2004 | 431 | 2004 |
| ENaC at the cutting edge: regulation of epithelial sodium channels by proteases TR Kleyman, MD Carattino, RP Hughey Journal of Biological Chemistry 284 (31), 20447-20451, 2009 | 352 | 2009 |
| Epithelial Na+ channels are fully activated by furin-and prostasin-dependent release of an inhibitory peptide from the γ-subunit JB Bruns, MD Carattino, S Sheng, AB Maarouf, OA Weisz, JM Pilewski, ... Journal of Biological Chemistry 282 (9), 6153-6160, 2007 | 350 | 2007 |
| Maturation of the epithelial Na+ channel involves proteolytic processing of the α-and γ-subunits RP Hughey, GM Mueller, JB Bruns, CL Kinlough, PA Poland, ... Journal of Biological Chemistry 278 (39), 37073-37082, 2003 | 306 | 2003 |
| Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state Y Altschuler, CL Kinlough, PA Poland, JB Bruns, G Apodaca, OA Weisz, ... Molecular biology of the cell 11 (3), 819-831, 2000 | 225 | 2000 |
| Plasmin activates epithelial Na+ channels by cleaving the γ subunit CJ Passero, GM Mueller, H Rondon-Berrios, SP Tofovic, RP Hughey, ... Journal of Biological Chemistry 283 (52), 36586-36591, 2008 | 213 | 2008 |
| Comparison of the size and physical properties of gamma-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with Triton X-100 RP Hughey, N Curthoys Journal of Biological Chemistry 251 (24), 7863-7870, 1976 | 207 | 1976 |
| Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition S Sheng, MD Carattino, JB Bruns, RP Hughey, TR Kleyman American Journal of Physiology-Renal Physiology 290 (6), F1488-F1496, 2006 | 200 | 2006 |
| Distinct pools of epithelial sodium channels are expressed at the plasma membrane RP Hughey, JB Bruns, CL Kinlough, TR Kleyman Journal of Biological Chemistry 279 (47), 48491-48494, 2004 | 187 | 2004 |
| The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its α subunit MD Carattino, S Sheng, JB Bruns, JM Pilewski, RP Hughey, TR Kleyman Journal of Biological Chemistry 281 (27), 18901-18907, 2006 | 180 | 2006 |
| Characterization and Physiological Function of Rat Renalγ-Glutamyltranspeptidase N Curthoys, R Hughey Enzymologia biologica et clinica 24 (6), 383-403, 1979 | 177 | 1979 |
| Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy M Dvela-Levitt, M Kost-Alimova, M Emani, E Kohnert, R Thompson, ... Cell 178 (3), 521-535. e23, 2019 | 145 | 2019 |
| Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis RP Hughey, BB Rankin, JS Elce, NP Curthoys Archives of biochemistry and biophysics 186 (2), 211-217, 1978 | 145 | 1978 |
| Role of epithelial sodium channels and their regulators in hypertension R Soundararajan, D Pearce, RP Hughey, TR Kleyman Journal of Biological Chemistry 285 (40), 30363-30369, 2010 | 138 | 2010 |
| Proteolytic processing of the epithelial sodium channel γ subunit has a dominant role in channel activation MD Carattino, RP Hughey, TR Kleyman Journal of biological chemistry 283 (37), 25290-25295, 2008 | 137 | 2008 |
| Role of N-and O-glycans in polarized biosynthetic sorting BA Potter, RP Hughey, OA Weisz American Journal of Physiology-Cell Physiology 290 (1), C1-C10, 2006 | 120 | 2006 |
| Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct T Morimoto, W Liu, C Woda, MD Carattino, Y Wei, RP Hughey, G Apodaca, ... American Journal of Physiology-Renal Physiology 291 (3), F663-F669, 2006 | 119 | 2006 |
| MUC1 and other sialoglycoconjugates inhibit adenovirus-mediated gene transfer to epithelial cells SM Arcasoy, J Latoche, M Gondor, SC Watkins, RA Henderson, ... American journal of respiratory cell and molecular biology 17 (4), 422-435, 1997 | 113 | 1997 |
| Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors TR Kleyman, OB Kashlan, RP Hughey Annual review of physiology 80, 263-281, 2018 | 100 | 2018 |
| Role of proteolysis in the activation of epithelial sodium channels RP Hughey, MD Carattino, TR Kleyman Current opinion in nephrology and hypertension 16 (5), 444-450, 2007 | 90 | 2007 |
