Nikhil T Awatade
Nikhil T Awatade
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Measurements of functional responses in human primary lung cells as a basis for personalized therapy for cystic fibrosis
NT Awatade, I Uliyakina, CM Farinha, LA Clarke, K Mendes, A Solé, ...
EBioMedicine 2 (2), 147-153, 2015
Human primary epithelial cell models: promising tools in the era of cystic fibrosis personalized medicine
NT Awatade, SL Wong, CK Hewson, LK Fawcett, A Kicic, A Jaffe, ...
Frontiers in Pharmacology 9, 1429, 2018
Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery
HM Botelho, I Uliyakina, NT Awatade, MC Proença, C Tischer, L Sirianant, ...
Scientific reports 5 (1), 9038, 2015
The third dimension: new developments in cell culture models for colorectal research
JFS Pereira, NT Awatade, CA Loureiro, P Matos, MD Amaral, P Jordan
Cellular and molecular life sciences 73, 3971-3989, 2016
R560S: A class II CFTR mutation that is not rescued by current modulators
NT Awatade, S Ramalho, IAL Silva, V Felício, HM Botelho, E de Poel, ...
Journal of Cystic Fibrosis 18 (2), 182-189, 2019
A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic
JR Lérias, MC Pinto, HM Botelho, NT Awatade, MC Quaresma, IAL Silva, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 421-431, 2018
Pharmacological evaluation of hybrid thiazolidin-4-one-1, 3, 5-triazines for NF-κB, biofilm and CFTR activity
JK Srivastava, NT Awatade, HR Bhat, A Kmit, K Mendes, M Ramos, ...
RSC advances 5 (108), 88710-88718, 2015
Significant functional differences in differentiated Conditionally Reprogrammed (CRC)-and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells
NT Awatade, SL Wong, A Capraro, E Pandzic, I Slapetova, L Zhong, ...
Journal of Cystic Fibrosis 20 (2), 364-371, 2021
The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read‐through …
LA Clarke, NT Awatade, VM Felício, IA Silva, M Calucho, L Pereira, ...
Human mutation 40 (3), 326-334, 2019
Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect
SL Wong, NT Awatade, MA Astore, KM Allan, MJ Carnell, I Slapetova, ...
American Journal of Respiratory Cell and Molecular Biology 67 (1), 99-111, 2022
An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay
MC Hagemeijer, AM Vonk, NT Awatade, IAL Silva, C Tischer, ...
Bioinformatics 36 (24), 5686-5694, 2020
Novel antioxidant therapy with the immediate precursor to glutathione, Γ-Glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in in vitro 3d-differentiated airway …
CK Hewson, A Capraro, SL Wong, E Pandzic, L Zhong, BSM Fernando, ...
Antioxidants 9 (12), 1204, 2020
The complex association between COPD and COVID-19
NT Awatade, PAB Wark, ASL Chan, SMAA Mamun, NY Mohd Esa, ...
Journal of Clinical Medicine 12 (11), 3791, 2023
Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity
SL Wong, NT Awatade, MA Astore, KM Allan, MJ Carnell, I Slapetova, ...
Iscience 25 (1), 2022
Comparison of commercially available differentiation media on cell morphology, function, and anti-viral responses in conditionally reprogrammed human bronchial epithelial cells
NT Awatade, AT Reid, KS Nichol, KF Budden, PC Veerati, ...
Scientific reports 13 (1), 11200, 2023
Type 2 immunity and its impact on COVID-19 infection in the airways
PS Pathinayake, NT Awatade, PAB Wark
Viruses 15 (2), 402, 2023
Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule
J Liu, H Bihler, CM Farinha, NT Awatade, AM Romao, D Mercadante, ...
Br. J. Pharmacol 175, 1017-1038, 2018
Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis. EBio-Medicine [Internet]. 2015 Feb [cited 2019 Oct 18 …
NT Awatade, I Uliyakina, CM Farinha, LA Clarke, K Mendes, A Solé
Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD …
NT Awatade, SL Wong, E Pandzic, I Slapetova, A Capraro, L Zhong, ...
bioRxiv, 2020.05. 29.120006, 2020
Functional and biochemical assessment of correctors and potentiators on the rare cystic fibrosis-causing R560S mutation
NT Awatade, V Felício, S Ramalho, HM Botelho, I Silva, E De Poel, ...
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