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Cheng Zhang
Cheng Zhang
Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine
Verified email at pitt.edu
Title
Cited by
Cited by
Year
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi, M Shiroishi, C Zhang, ...
Nature 482 (7386), 547-551, 2012
9182012
Structure and function of an irreversible agonist-β2 adrenoceptor complex
DM Rosenbaum, C Zhang, JA Lyons, R Holl, D Aragao, DH Arlow, ...
Nature 469 (7329), 236-240, 2011
9082011
High-resolution crystal structure of human protease-activated receptor 1
C Zhang, Y Srinivasan, DH Arlow, JJ Fung, D Palmer, Y Zheng, HF Green, ...
Nature 492 (7429), 387-392, 2012
5272012
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Y Xiang, S Nambulli, Z Xiao, H Liu, Z Sang, WP Duprex, ...
Science 370 (6523), 1479-1484, 2020
3492020
Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex
C Xing, Y Zhuang, TH Xu, Z Feng, XE Zhou, M Chen, L Wang, X Meng, ...
Cell 180 (4), 645-654. e13, 2020
2012020
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
M Zocher, C Zhang, SGF Rasmussen, BK Kobilka, DJ Müller
Proceedings of the National Academy of Sciences 109 (50), E3463-E3472, 2012
1772012
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
M Masureel, Y Zou, LP Picard, E van der Westhuizen, JP Mahoney, ...
Nature chemical biology 14 (11), 1059-1066, 2018
1672018
Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Y Zhuang, P Xu, C Mao, L Wang, B Krumm, XE Zhou, S Huang, H Liu, ...
Cell 184 (4), 931-942. e18, 2021
1562021
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
X Qi, H Liu, B Thompson, J McDonald, C Zhang, X Li
Nature 571 (7764), 279-283, 2019
1462019
Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape
D Alsteens, M Pfreundschuh, C Zhang, PM Spoerri, SR Coughlin, ...
Nature methods 12 (9), 845-851, 2015
1232015
Covalent agonists for studying G protein-coupled receptor activation
D Weichert, AC Kruse, A Manglik, C Hiller, C Zhang, H Hübner, ...
Proceedings of the National Academy of Sciences 111 (29), 10744-10748, 2014
1162014
Orthosteric and allosteric action of the C5a receptor antagonists
H Liu, HR Kim, RNVK Deepak, L Wang, KY Chung, H Fan, Z Wei, ...
Nature structural & molecular biology 25 (6), 472-481, 2018
1072018
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
Y Zhuang, H Liu, X Edward Zhou, R Kumar Verma, PW de Waal, W Jang, ...
Nature communications 11 (1), 885, 2020
932020
Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides
J Li, C Zhang, X Xu, J Wang, H Yu, R Lai, W Gong
The FASEB Journal 21 (10), 2466-2473, 2007
882007
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
D Sun, Z Sang, YJ Kim, Y Xiang, T Cohen, AK Belford, A Huet, JF Conway, ...
Nature communications 12 (1), 4676, 2021
872021
G protein–coupled receptors in asthma therapy: pharmacology and drug action
SG Wendell, H Fan, C Zhang
Pharmacological reviews 72 (1), 1-49, 2020
792020
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM
M Pfreundschuh, D Alsteens, R Wieneke, C Zhang, SR Coughlin, ...
Nature communications 6 (1), 8857, 2015
782015
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Q Xiao, L Wang, S Supekar, T Shen, H Liu, F Ye, J Huang, H Fan, Z Wei, ...
Nature Communications 11 (1), 5430, 2020
652020
Structures of the human PGD2 receptor CRTH2 reveal novel mechanisms for ligand recognition
L Wang, D Yao, RNVK Deepak, H Liu, Q Xiao, H Fan, W Gong, Z Wei, ...
Molecular cell 72 (1), 48-59. e4, 2018
622018
Effective application of bicelles for conformational analysis of G protein-coupled receptors by hydrogen/deuterium exchange mass spectrometry
NM Duc, Y Du, TS Thorsen, SY Lee, C Zhang, H Kato, BK Kobilka, ...
Journal of the American Society for Mass Spectrometry 26 (5), 808-817, 2015
572015
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