| PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells A Boire, L Covic, A Agarwal, S Jacques, S Sherifi, A Kuliopulos Cell 120 (3), 303-313, 2005 | 1032 | 2005 |
| Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides L Covic, AL Gresser, J Talavera, S Swift, A Kuliopulos Proceedings of the National Academy of Sciences 99 (2), 643-648, 2002 | 427 | 2002 |
| Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets L Covic, AL Gresser, A Kuliopulos Biochemistry 39 (18), 5458-5467, 2000 | 363 | 2000 |
| Protease-activated receptors in cardiovascular diseases AJ Leger, L Covic, A Kuliopulos Circulation 114 (10), 1070-1077, 2006 | 357 | 2006 |
| Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation L Covic, M Misra, J Badar, C Singh, A Kuliopulos Nature medicine 8 (10), 1161-1165, 2002 | 339 | 2002 |
| Disruption of the mouse μ-calpain gene reveals an essential role in platelet function M Azam, SS Andrabi, KE Sahr, L Kamath, A Kuliopulos, AH Chishti Molecular and cellular biology 21 (6), 2213-2220, 2001 | 327 | 2001 |
| 'Role reversal'for the receptor PAR1 in sepsis-induced vascular damage NC Kaneider, AJ Leger, A Agarwal, N Nguyen, G Perides, C Derian, ... Nature immunology 8 (12), 1303-1312, 2007 | 276 | 2007 |
| Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site V Trivedi, A Boire, B Tchernychev, NC Kaneider, AJ Leger, K O'Callaghan, ... Cell 137 (2), 332-343, 2009 | 275 | 2009 |
| Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis AJ Leger, SL Jacques, J Badar, NC Kaneider, CK Derian, ... Circulation 113 (9), 1244-1254, 2006 | 265 | 2006 |
| Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy A Kuliopulos, L Covic, SK Seeley, PJ Sheridan, J Helin, CE Costello Biochemistry 38 (14), 4572-4585, 1999 | 265 | 1999 |
| Matrix metalloproteases and PAR1 activation KM Austin, L Covic, A Kuliopulos Blood, The Journal of the American Society of Hematology 121 (3), 431-439, 2013 | 204 | 2013 |
| Quantitative interpretations of double mutations of enzymes AS Mildvan, DJ Weber, A Kuliopulos Archives of biochemistry and biophysics 294 (2), 327-340, 1992 | 202 | 1992 |
| Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells L Kamath, A Meydani, F Foss, A Kuliopulos Cancer research 61 (15), 5933-5940, 2001 | 190 | 2001 |
| Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development K O'Callaghan, A Kuliopulos, L Covic Journal of Biological Chemistry 287 (16), 12787-12796, 2012 | 184 | 2012 |
| Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis E Yang, A Boire, A Agarwal, N Nguyen, K O'Callaghan, P Tu, A Kuliopulos, ... Cancer research 69 (15), 6223-6231, 2009 | 177 | 2009 |
| Reversing systemic inflammatory response syndrome with chemokine receptor pepducins NC Kaneider, A Agarwal, AJ Leger, A Kuliopulos Nature medicine 11 (6), 661-665, 2005 | 171 | 2005 |
| Production, purification, and cleavage of tandem repeats of recombinant peptides A Kuliopulos, CT Walsh Journal of the American Chemical Society 116 (11), 4599-4607, 1994 | 170 | 1994 |
| Kinetic and ultraviolet spectroscopic studies of active-site mutants of. DELTA. 5-3-ketosteroid isomerase A Kuliopulos, AS Mildvan, D Shortle, P Talalay Biochemistry 28 (1), 149-159, 1989 | 168 | 1989 |
| G-protein–coupled receptors as signaling targets for antiplatelet therapy SS Smyth, DS Woulfe, JI Weitz, C Gachet, PB Conley, SG Goodman, ... Arteriosclerosis, thrombosis, and vascular biology 29 (4), 449-457, 2009 | 146 | 2009 |
| A matrix metalloprotease‐PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis SL Tressel, NC Kaneider, S Kasuda, C Foley, G Koukos, K Austin, ... EMBO molecular medicine 3 (7), 370-384, 2011 | 141 | 2011 |
