Oncogenic kinase signalling P Blume-Jensen, T Hunter Nature 411 (6835), 355-365, 2001 | 5272 | 2001 |
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136 P Blume-Jensen, R Janknecht, T Hunter Current biology 8 (13), 779-785, 1998 | 478 | 1998 |
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase Z Lu, G Jiang, P Blume-Jensen, T Hunter Molecular and cellular biology, 2001 | 430 | 2001 |
Activation of the human c‐kit product by ligand‐induced dimerization mediates circular actin reorganization and chemotaxis. P Blume‐Jensen, L Claesson‐Welsh, A Siegbahn, KM Zsebo, ... The EMBO journal 10 (13), 4121-4128, 1991 | 400 | 1991 |
Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility P Blume-Jensen, G Jiang, R Hyman, KF Lee, S O'Gorman, T Hunter Nature genetics 24 (2), 157-162, 2000 | 370 | 2000 |
Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction J Lennartsson, P Blume-Jensen, M Hermanson, E Pontén, M Carlberg, ... Oncogene 18 (40), 5546-5553, 1999 | 239 | 1999 |
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors JN Andersen, S Sathyanarayanan, A Di Bacco, A Chi, T Zhang, AH Chen, ... Science translational medicine 2 (43), 43ra55-43ra55, 2010 | 224 | 2010 |
Development and Clinical Validation of an In Situ Biopsy-Based Multimarker Assay for Risk Stratification in Prostate Cancer P Blume-Jensen, DM Berman, DL Rimm, M Shipitsin, M Putzi, TP Nifong, ... Clinical cancer research 21 (11), 2591-2600, 2015 | 202 | 2015 |
Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error M Shipitsin, C Small, S Choudhury, E Giladi, S Friedlander, J Nardone, ... British journal of cancer 111 (6), 1201-1212, 2014 | 168 | 2014 |
Fibroblast growth factor receptor-1 regulation of Src family kinases. E Landgren, P Blume-Jensen, SA Courtneidge, L Claesson-Welsh Oncogene 10 (10), 2027-2035, 1995 | 132 | 1995 |
Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C. P Blume‐Jensen, A Siegbahn, S Stabel, CH Heldin, L Rönnstrand The EMBO journal 12 (11), 4199-4209, 1993 | 131 | 1993 |
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. P Blume-Jensen, L Rönnstrand, I Gout, MD Waterfield, CH Heldin Journal of Biological Chemistry 269 (34), 21793-21802, 1994 | 127 | 1994 |
Identification of the Major Phosphorylation Sites for Protein Kinase C in Kit/Stem Cell Factor Receptor in Vitro and in Intact Cells∗ P Blume-Jensen, C Wernstedt, CH Heldin, L Rönnstrand Journal of Biological Chemistry 270 (23), 14192-14200, 1995 | 121 | 1995 |
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor K Nagashima, SD Shumway, S Sathyanarayanan, AH Chen, B Dolinski, ... Journal of biological chemistry 286 (8), 6433-6448, 2011 | 78 | 2011 |
Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate … M Shipitsin, C Small, E Giladi, S Siddiqui, S Choudhury, S Hussain, ... Proteome Science 12, 1-13, 2014 | 69 | 2014 |
Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening EV Bobkova, MJ Weber, Z Xu, YL Zhang, J Jung, P Blume-Jensen, ... Journal of biological chemistry 285 (24), 18838-18846, 2010 | 58 | 2010 |
Involvement of phosphatidylinositol 3′‐kinase in stem‐cell‐factor‐induced phospholipase D activation and arachidonic acid release O Kozawa, P Blume‐Jensen, CH Heldin, L Rönnstrand European journal of biochemistry 248 (1), 149-155, 1997 | 53 | 1997 |
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models K Ellwood-Yen, H Keilhack, K Kunii, B Dolinski, Y Connor, K Hu, ... Cancer research 71 (8), 3052-3065, 2011 | 35 | 2011 |
The platelet-derived growth factor beta-receptor kinase insert confers specific signaling properties to a chimeric fibroblast growth factor receptor. S Wennström, E Landgren, P Blume-Jensen, L Claesson-Welsh Journal of Biological Chemistry 267 (19), 13749-13756, 1992 | 32 | 1992 |
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs MR Golder, J Liu, JN Andersen, MV Shipitsin, F Vohidov, HVT Nguyen, ... Nature biomedical engineering 2 (11), 822-830, 2018 | 31 | 2018 |