Denis Wirtz
Denis Wirtz
T.H. Smoot Professor of Engineering Science, Pathology, and Oncology; VP Research, Johns Hopkins
Verified email at - Homepage
Cited by
Cited by
The physics of cancer: the role of physical interactions and mechanical forces in metastasis
D Wirtz, K Konstantopoulos, PC Searson
Nature Reviews Cancer 11 (7), 512-522, 2011
Hypoxia and the extracellular matrix: drivers of tumour metastasis
DM Gilkes, GL Semenza, D Wirtz
Nature Reviews Cancer 14 (6), 430-439, 2014
Reversible hydrogels from self-assembling artificial proteins
WA Petka, JL Harden, KP McGrath, D Wirtz, DA Tirrell
Science 281 (5375), 389-392, 1998
Micro-and macrorheology of mucus
SK Lai, YY Wang, D Wirtz, J Hanes
Advanced drug delivery reviews 61 (2), 86-100, 2009
Particle tracking microrheology of complex fluids
TG Mason, K Ganesan, JH van Zanten, D Wirtz, SC Kuo
Physical review letters 79 (17), 3282, 1997
Particle-tracking microrheology of living cells: principles and applications
D Wirtz
Annual review of biophysics 38 (1), 301-326, 2009
A distinctive role for focal adhesion proteins in three-dimensional cell motility
SI Fraley, Y Feng, R Krishnamurthy, DH Kim, A Celedon, GD Longmore, ...
Nature cell biology 12 (6), 598-604, 2010
A perinuclear actin cap regulates nuclear shape
SB Khatau, CM Hale, PJ Stewart-Hutchinson, MS Patel, CL Stewart, ...
Proceedings of the National Academy of Sciences 106 (45), 19017-19022, 2009
Mechanics of living cells measured by laser tracking microrheology
S Yamada, D Wirtz, SC Kuo
Biophysical journal 78 (4), 1736-1747, 2000
A comparison of methods to assess cell mechanical properties
PH Wu, DRB Aroush, A Asnacios, WC Chen, ME Dokukin, BL Doss, ...
Nature methods 15 (7), 491-498, 2018
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts
DM Gilkes, S Bajpai, P Chaturvedi, D Wirtz, GL Semenza
Journal of Biological Chemistry 288 (15), 10819-10829, 2013
Water permeation drives tumor cell migration in confined microenvironments
KM Stroka, H Jiang, SH Chen, Z Tong, D Wirtz, SX Sun, ...
Cell 157 (3), 611-623, 2014
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
CCL Wong, DM Gilkes, H Zhang, J Chen, H Wei, P Chaturvedi, SI Fraley, ...
Proceedings of the National Academy of Sciences 108 (39), 16369-16374, 2011
Efficient active transport of gene nanocarriers to the cell nucleus
J Suh, D Wirtz, J Hanes
Proceedings of the National Academy of Sciences 100 (7), 3878-3882, 2003
Micromechanical mapping of live cells by multiple-particle-tracking microrheology
Y Tseng, TP Kole, D Wirtz
Biophysical journal 83 (6), 3162-3176, 2002
Focal adhesion size uniquely predicts cell migration
DH Kim, D Wirtz
Biophysical Journal 104 (2), 319a, 2013
Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes
A Agarwal, PH Wu, EG Hughes, M Fukaya, MA Tischfield, AJ Langseth, ...
Neuron 93 (3), 587-605. e7, 2017
Three-dimensional cell migration does not follow a random walk
PH Wu, A Giri, SX Sun, D Wirtz
Proceedings of the National Academy of Sciences 111 (11), 3949-3954, 2014
Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport
M Dawson, D Wirtz, J Hanes
Journal of Biological Chemistry 278 (50), 50393-50401, 2003
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration
JSH Lee, CM Hale, P Panorchan, SB Khatau, JP George, Y Tseng, ...
Biophysical journal 93 (7), 2542-2552, 2007
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