Paul M. O'Neill
Paul M. O'Neill
Department of Chemistry
Verified email at liv.ac.uk - Homepage
Title
Cited by
Cited by
Year
Artemisinins target the SERCA of Plasmodium falciparum
U Eckstein-Ludwig, RJ Webb, IDA Van Goethem, JM East, AG Lee, ...
Nature 424 (6951), 957-961, 2003
12462003
Metabolism of fluorine-containing drugs
BK Park, NR Kitteringham, PM O'Neill
Annual review of pharmacology and toxicology 41 (1), 443-470, 2001
6932001
The molecular mechanism of action of artemisinin—the debate continues
PM O’neill, VE Barton, SA Ward
Molecules 15 (3), 1705-1721, 2010
6392010
A medicinal chemistry perspective on artemisinin and related endoperoxides
PM O'Neill, GH Posner
Journal of medicinal chemistry 47 (12), 2945-2964, 2004
6122004
4-Aminoquinolines—Past, present, and future; A chemical perspective
PM O'Neill, PG Bray, SR Hawley, SA Ward, BK Park
Pharmacology & therapeutics 77 (1), 29-58, 1998
3611998
Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial …
GH Posner, PM O'Neill
Accounts of chemical research 37 (6), 397-404, 2004
2542004
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds
AE Mercer, JL Maggs, XM Sun, GM Cohen, J Chadwick, PM O'Neill, ...
Journal of Biological Chemistry 282 (13), 9372-9382, 2007
2312007
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: sequential metabolism of deltamethrin revealed
BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ...
Insect biochemistry and molecular biology 41 (7), 492-502, 2011
2282011
Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro
SR Hawley, PG Bray, M Mungthin, JD Atkinson, PM O’Neill, SA Ward
Antimicrobial agents and chemotherapy 42 (3), 682-686, 1998
2171998
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
HM Ismail, V Barton, M Phanchana, S Charoensutthivarakul, MHL Wong, ...
Proceedings of the National Academy of Sciences 113 (8), 2080-2085, 2016
1932016
Quinolines and artemisinin: chemistry, biology and history
PG Bray, SA Ward, PM O’neill
Malaria: drugs, disease and post-genomic biology, 3-38, 2005
1742005
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials
AE Mercer, IM Copple, JL Maggs, PM O'Neill, BK Park
Journal of Biological Chemistry 286 (2), 987-996, 2011
1672011
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ...
Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012
1622012
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials
PM O'Neill, A Mukhtar, PA Stocks, LE Randle, S Hindley, SA Ward, ...
Journal of medicinal chemistry 46 (23), 4933-4945, 2003
1592003
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum
PA Stocks, KJ Raynes, PG Bray, BK Park, PM O'Neill, SA Ward
Journal of medicinal chemistry 45 (23), 4975-4983, 2002
1532002
Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria
GA Biagini, P Viriyavejakul, PM O'neill, PG Bray, SA Ward
Antimicrobial agents and chemotherapy 50 (5), 1841-1851, 2006
1472006
Identification of a 1, 2, 4, 5‐tetraoxane antimalarial drug‐development candidate (RKA 182) with superior properties to the semisynthetic artemisinins
PM O'Neill, RK Amewu, GL Nixon, F Bousejra ElGarah, M Mungthin, ...
Angewandte Chemie 122 (33), 5829-5833, 2010
1452010
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues
S Hindley, SA Ward, RC Storr, NL Searle, PG Bray, BK Park, J Davies, ...
Journal of medicinal chemistry 45 (5), 1052-1063, 2002
1392002
Evidence for a common non‐heme chelatable‐iron‐dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
PA Stocks, PG Bray, VE Barton, M Al‐Helal, M Jones, NC Araujo, ...
Angewandte Chemie International Edition 46 (33), 6278-6283, 2007
1362007
Changes in spinal cord regenerative ability through phylogenesis and development: lessons to be learnt
P Ferretti, F Zhang, P O'Neill
Developmental dynamics: an official publication of the American Association …, 2003
1322003
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