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Paul M. O'Neill
Paul M. O'Neill
Department of Chemistry
Verified email at liv.ac.uk - Homepage
Title
Cited by
Cited by
Year
Artemisinins target the SERCA of Plasmodium falciparum
U Eckstein-Ludwig, RJ Webb, IDA Van Goethem, JM East, AG Lee, ...
Nature 424 (6951), 957-961, 2003
13492003
Metabolism of fluorine-containing drugs
BK Park, NR Kitteringham, PM O'Neill
Annual review of pharmacology and toxicology 41 (1), 443-470, 2001
8002001
The molecular mechanism of action of artemisinin—the debate continues
PM O’Neill, VE Barton, SA Ward
Molecules 15 (3), 1705-1721, 2010
7632010
A medicinal chemistry perspective on artemisinin and related endoperoxides
PM O'Neill, GH Posner
Journal of medicinal chemistry 47 (12), 2945-2964, 2004
6812004
4-Aminoquinolines—Past, present, and future; A chemical perspective
PM O'Neill, PG Bray, SR Hawley, SA Ward, BK Park
Pharmacology & therapeutics 77 (1), 29-58, 1998
3941998
Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial …
GH Posner, PM O'Neill
Accounts of chemical research 37 (6), 397-404, 2004
2882004
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
HM Ismail, V Barton, M Phanchana, S Charoensutthivarakul, MHL Wong, ...
Proceedings of the National Academy of Sciences 113 (8), 2080-2085, 2016
2752016
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ...
Insect biochemistry and molecular biology 41 (7), 492-502, 2011
2692011
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds
AE Mercer, JL Maggs, XM Sun, GM Cohen, J Chadwick, PM O'Neill, ...
Journal of Biological Chemistry 282 (13), 9372-9382, 2007
2572007
Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro
SR Hawley, PG Bray, M Mungthin, JD Atkinson, PM O’Neill, SA Ward
Antimicrobial agents and chemotherapy 42 (3), 682-686, 1998
2331998
Quinolines and artemisinin: chemistry, biology and history
PG Bray, SA Ward, PM O’neill
Malaria: drugs, disease and post-genomic biology, 3-38, 2005
2052005
Antimalarial pharmacology and therapeutics of atovaquone
GL Nixon, DM Moss, AE Shone, DG Lalloo, N Fisher, PM O'Neill, SA Ward, ...
Journal of Antimicrobial Chemotherapy 68 (5), 977-985, 2013
2002013
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ...
Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012
1922012
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials
AE Mercer, IM Copple, JL Maggs, PM O'Neill, BK Park
Journal of Biological Chemistry 286 (2), 987-996, 2011
1872011
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials
PM O'Neill, A Mukhtar, PA Stocks, LE Randle, S Hindley, SA Ward, ...
Journal of medicinal chemistry 46 (23), 4933-4945, 2003
1832003
Novel Short Chain Chloroquine Analogues Retain Activity Against Chloroquine Resistant K1 Plasmodium falciparum
PA Stocks, KJ Raynes, PG Bray, BK Park, PM O'Neill, SA Ward
Journal of Medicinal Chemistry 45 (23), 4975-4983, 2002
1712002
Identification of a 1, 2, 4, 5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins
PM O'Neill, RK Amewu, GL Nixon, F BousejraElGarah, M Mungthin, ...
Angewandte Chemie-International Edition 49 (33), 5693, 2010
1682010
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
PA Stocks, PG Bray, VE Barton, M Al-Helal, M Jones, NC Araujo, ...
Angewandte Chemie-International Edition 46 (33), 6278-6283, 2007
1682007
Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria
GA Biagini, P Viriyavejakul, PM O'neill, PG Bray, SA Ward
Antimicrobial agents and chemotherapy 50 (5), 1841-1851, 2006
1682006
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
K Amporndanai, X Meng, W Shang, Z Jin, M Rogers, Y Zhao, Z Rao, ...
Nature communications 12 (1), 3061, 2021
1602021
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