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John Paul Donohue
John Paul Donohue
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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
M Polymenidou, C Lagier-Tourenne, KR Hutt, SC Huelga, J Moran, ...
Nature neuroscience 14 (4), 459-468, 2011
13502011
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
C Lagier-Tourenne, M Polymenidou, KR Hutt, AQ Vu, M Baughn, ...
Nature neuroscience 15 (11), 1488-1497, 2012
8052012
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
JZ Ni, L Grate, JP Donohue, C Preston, N Nobida, G O’Brien, L Shiue, ...
Genes & development 21 (6), 708-718, 2007
5852007
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins
SC Huelga, AQ Vu, JD Arnold, TY Liang, PP Liu, BY Yan, JP Donohue, ...
Cell reports 1 (2), 167-178, 2012
4882012
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy
H Du, MS Cline, RJ Osborne, DL Tuttle, TA Clark, JP Donohue, MP Hall, ...
Nature structural & molecular biology 17 (2), 187-193, 2010
3712010
A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
SB Cohen, S Proudman, AJ Kivitz, FX Burch, JP Donohue, D Burstein, ...
Arthritis research & therapy 13, 1-12, 2011
2742011
Crystal structures of EF-G–ribosome complexes trapped in intermediate states of translocation
J Zhou, L Lancaster, JP Donohue, HF Noller
Science 340 (6140), 1236086, 2013
2422013
How the ribosome hands the A-site tRNA to the P site during EF-G–catalyzed translocation
J Zhou, L Lancaster, JP Donohue, HF Noller
Science 345 (6201), 1188-1191, 2014
1842014
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
K Kapeli, GA Pratt, AQ Vu, KR Hutt, FJ Martinez, B Sundararaman, ...
Nature communications 7 (1), 12143, 2016
1822016
Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation
MP Hall, RJ Nagel, WS Fagg, L Shiue, MS Cline, RJ Perriman, ...
Rna 19 (5), 627-638, 2013
1662013
Protein-RNA networks regulated by normal and ALS-associated mutant HNRNPA2B1 in the nervous system
FJ Martinez, GA Pratt, EL Van Nostrand, R Batra, SC Huelga, K Kapeli, ...
Neuron 92 (4), 780-795, 2016
1622016
Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing
EM Munding, L Shiue, S Katzman, JP Donohue, M Ares
Molecular cell 51 (3), 338-348, 2013
1222013
Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster
AJ Dobson, JM Chaston, PD Newell, L Donahue, SL Hermann, ...
Nature communications 6 (1), 6312, 2015
1132015
Molecular mechanics of 30S subunit head rotation
S Mohan, JP Donohue, HF Noller
Proceedings of the National Academy of Sciences 111 (37), 13325-13330, 2014
1052014
Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis
K Chakrabarti, M Pearson, L Grate, T Sterne-Weiler, J Deans, ...
Rna 13 (11), 1923-1939, 2007
1032007
Initiation of translation in bacteria by a structured eukaryotic IRES RNA
TM Colussi, DA Costantino, J Zhu, JP Donohue, AA Korostelev, ZA Jaafar, ...
Nature 519 (7541), 110-113, 2015
632015
Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome
J Zhu, A Korostelev, DA Costantino, JP Donohue, HF Noller, JS Kieft
Proceedings of the National Academy of Sciences 108 (5), 1839-1844, 2011
552011
Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state
J Zhou, L Lancaster, JP Donohue, HF Noller
Proceedings of the National Academy of Sciences 116 (16), 7813-7818, 2019
502019
Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation
WS Fagg, N Liu, JH Fair, L Shiue, S Katzman, JP Donohue, M Ares
Genes & development 31 (18), 1894-1909, 2017
452017
RNA-binding protein CPEB1 remodels host and viral RNA landscapes
R Batra, TJ Stark, AE Clark, JP Belzile, EC Wheeler, BA Yee, H Huang, ...
Nature structural & molecular biology 23 (12), 1101-1110, 2016
422016
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