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Jia-Yu Chen
Jia-Yu Chen
PKU, UCSD, NJU
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Expanded encyclopaedias of DNA elements in the human and mouse genomes
The ENCODE Project Consortium
Nature 583 (7818), 699-710, 2020
16012020
A large-scale binding and functional map of human RNA-binding proteins
EL Van Nostrand*, P Freese*, GA Pratt*, X Wang*, X Wei*, R Xiao*, ...
Nature 583 (7818), 711-719, 2020
9832020
R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters
L Chen*, JY Chen*, X Zhang, Y Gu, R Xiao, C Shao, P Tang, H Qian, ...
Molecular Cell, 2017
3502017
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription
R Xiao*, JY Chen*, Z Liang*, D Luo, G Chen, ZJ Lu, Y Chen, B Zhou, H Li, ...
Cell 178 (1), 107-121. e18, 2019
2912019
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
L Chen*, JY Chen*, YJ Huang*, Y Gu, J Qiu, H Qian, C Shao, X Zhang, ...
Molecular Cell, 2018
2802018
Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs
C Xie*, YE Zhang*, JY Chen*, CJ Liu, WZ Zhou, Y Li, M Zhang, R Zhang, ...
PLoS Genetics 8 (9), e1002942, 2012
1732012
Perspectives on ENCODE
The ENCODE Project Consortium
Nature 583 (7818), 693-698, 2020
109*2020
RNA editome in rhesus macaque shaped by purifying selection
JY Chen*, Z Peng*, R Zhang*, XZ Yang, BCM Tan, H Fang, CJ Liu, M Shi, ...
PLoS genet 10 (4), e1004274, 2014
862014
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1
JY Chen, X Zhang, XD Fu^, L Chen^
Nature protocols 14 (5), 1661-1685, 2019
712019
Emergence, retention and selection: a trilogy of origination for functional de novo proteins from ancestral LncRNAs in primates
JY Chen*, QS Shen*, WZ Zhou*, J Peng, BZ He, Y Li, CJ Liu, X Luan, ...
PLoS genetics 11 (7), e1005391, 2015
642015
Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors
L Lei*, SY Yan*, R Yang, JY Chen, Y Li, Y Bu, N Chang, Q Zhou, X Zhu, ...
Nucleic acids research 45 (6), 3422-3436, 2017
622017
Nexilin is a new component of junctional membrane complexes required for cardiac T-tubule formation
C Liu*, S Spinozzi*, JY Chen, X Fang, W Feng, G Perkins, P Cattaneo, ...
Circulation 140 (1), 55-66, 2019
572019
c-Myc-targeting PROTAC based on a TNA-DNA bivalent binder for combination therapy of triple-negative breast cancer
X Li, Z Zhang, F Gao, Y Ma, D Wei, Z Lu, S Chen, M Wang, Y Wang, K Xu, ...
Journal of the American Chemical Society 145 (16), 9334-9342, 2023
512023
Isoform evolution in primates through independent combination of alternative RNA processing events
SJ Zhang*, C Wang*, S Yan*, A Fu, X Luan, Y Li, Q Sunny Shen, X Zhong, ...
Molecular biology and evolution 34 (10), 2453-2468, 2017
452017
De novo genes with an lncRNA origin encode unique human brain developmental functionality
NA An, J Zhang, F Mo, X Luan, L Tian, QS Shen, X Li, C Li, F Zhou, ...
Nature ecology & evolution 7 (2), 264-278, 2023
442023
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination
Y Wang*, Y Wang*, D Song, X Sun, Z Li^, JY Chen, H Yu^
Nature Chemistry 14 (3), 350-359, 2022
442022
R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation
R Lin*, X Zhong*^, Y Zhou*, H Geng, Q Hu, Z Huang, J Hu, XD Fu, ...
Nucleic Acids Research, 2021
402021
Evolutionary interrogation of human biology in well-annotated genomic framework of rhesus macaque
SJ Zhang*, CJ Liu*, P Yu*, X Zhong, JY Chen, X Yang, J Peng, S Yan, ...
Molecular biology and evolution 31 (5), 1309-1324, 2014
392014
RhesusBase: a knowledgebase for the monkey research community
SJ Zhang*, CJ Liu*, M Shi*, L Kong, JY Chen, WZ Zhou, X Zhu, P Yu, ...
Nucleic Acids Research, 2012
362012
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers
J Xu, W Wang, L Xu, JY Chen, J Chong, J Oh, AE Leschziner, XD Fu, ...
Proceedings of the National Academy of Sciences 117 (41), 25486-25493, 2020
352020
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