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Yangshin Park
Yangshin Park
Biochemistry and Molecular Biology, Indiana University School of Medicine
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Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17
M Han, Y Park, I Kim, EH Kim, TK Yu, S Rhee, JY Suh
Proceedings of the National Academy of Sciences 111 (52), 18613-18618, 2014
842014
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)
S Abdeen, T Kunkle, N Salim, AM Ray, N Mammadova, C Summers, ...
Journal of medicinal chemistry 61 (16), 7345-7357, 2018
402018
Structure of bacteriophage SPN 1 S endolysin reveals an unusual two‐module fold for the peptidoglycan lytic and binding activity
Y Park, JA Lim, M Kong, S Ryu, S Rhee
Molecular microbiology 92 (2), 316-325, 2014
372014
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules
M Stevens, S Abdeen, N Salim, AM Ray, A Washburn, S Chitre, J Sivinski, ...
Bioorganic & medicinal chemistry letters 29 (9), 1106-1112, 2019
332019
The Parkinson's disease–associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2
X Huang, C Wu, Y Park, X Long, QQ Hoang, J Liao
The FASEB Journal 33 (4), 4814, 2019
282019
Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics
CX Wu, J Liao, Y Park, X Reed, VA Engel, NC Hoang, Y Takagi, ...
Journal of Biological Chemistry 294 (15), 5907-5913, 2019
262019
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus
T Kunkle, S Abdeen, N Salim, AM Ray, M Stevens, AJ Ambrose, ...
Journal of medicinal chemistry 61 (23), 10651-10664, 2018
262018
Crystal structure and functional analysis of isocitrate lyases from Magnaporthe oryzae and Fusarium graminearum
Y Park, Y Cho, YH Lee, YW Lee, S Rhee
Journal of Structural Biology 194 (3), 395-403, 2016
182016
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
A Washburn, S Abdeen, Y Ovechkina, AM Ray, M Stevens, S Chitre, ...
Bioorganic & medicinal chemistry letters 29 (13), 1665-1672, 2019
162019
Crystal structure of the effector protein HopA1 from Pseudomonas syringae
Y Park, I Shin, S Rhee
Journal of structural biology 189 (3), 276-280, 2015
122015
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs
M Stevens, C Howe, AM Ray, A Washburn, S Chitre, J Sivinski, Y Park, ...
Bioorganic & medicinal chemistry 28 (22), 115710, 2020
112020
Functional differences between E. Coli and eskape pathogen groes/groel
J Sivinski, AJ Ambrose, I Panfilenko, CJ Zerio, JM Machulis, N Mollasalehi, ...
Mbio 12 (1), 10.1128/mbio. 02167-20, 2021
82021
Roc, the G-domain of the Parkinson’s disease-associated protein LRRK2
Y Park, J Liao, QQ Hoang
Trends in biochemical sciences 47 (12), 1038-1047, 2022
52022
Functional differences between E. coli and ESKAPE pathogen GroES
J Sivinski, AJ Ambrose, I Panfilenko, CJ Zerio, JM Machulis, N Mollasalehi, ...
GroEL. mBio 12 (1), 2021
52021
A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms
CX Wu, J Liao, Y Park, NC Hoang, VA Engel, L Wan, M Oh, R Sanishvili, ...
BioRxiv, 676627, 2019
52019
Combating Parkinson’s disease-associated toxicity by modulating proteostasis
Y Park, QQ Hoang
Proceedings of the National Academy of Sciences 114 (5), 803-804, 2017
42017
Allosteric differences dictate GroEL complementation of E. coli
J Sivinski, D Ngo, CJ Zerio, AJ Ambrose, ER Watson, LK Kaneko, ...
FASEB journal: official publication of the Federation of American Societies …, 2022
12022
SMALL MOLECULE MODULATION OF HSP60/10 CHAPERONIN SYSTEMS: MORE COMMON THAN PREVIOUSLY THOUGHT?
M Stevens, S Abdeen, N Salim, AM Ray, A Washburn, S Chitre, J Sivinski, ...
PROTEIN SCIENCE 28, 112-113, 2019
2019
Small-molecule modulation of HSP60/10 chaperonin systems: A therapeutic strategy over 100 years in the making?
M Stevens, S Abdeen, AM Ray, A Washburn, S Chitre, J Sivinski, Y Park, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019
2019
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