| Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1 W Xu, MR Edwards, DM Borek, AR Feagins, A Mittal, JB Alinger, KN Berry, ... Cell host & microbe 16 (2), 187-200, 2014 | 253 | 2014 |
| Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation A Rialdi, L Campisi, N Zhao, AC Lagda, C Pietzsch, JSY Ho, ... Science 352 (6289), aad7993, 2016 | 152 | 2016 |
| Structural basis for Marburg virus VP35–mediated immune evasion mechanisms P Ramanan, MR Edwards, RS Shabman, DW Leung, AC Endlich-Frazier, ... Proceedings of the National Academy of Sciences 109 (50), 20661-20666, 2012 | 118 | 2012 |
| The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway MR Edwards, B Johnson, CE Mire, W Xu, RS Shabman, LN Speller, ... Cell reports 6 (6), 1017-1025, 2014 | 109 | 2014 |
| Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses P Luthra, J Naidoo, CA Pietzsch, S De, S Khadka, M Anantpadma, ... Antiviral research 158, 288-302, 2018 | 86 | 2018 |
| Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells RS Shabman, OJ Jabado, CE Mire, TB Stockwell, M Edwards, M Mahajan, ... MBio 5 (6), 10.1128/mbio. 02011-14, 2014 | 86 | 2014 |
| Differential regulation of interferon responses by Ebola and Marburg virus VP35 proteins MR Edwards, G Liu, CE Mire, S Sureshchandra, P Luthra, B Yen, ... Cell reports 14 (7), 1632-1640, 2016 | 80 | 2016 |
| High-throughput minigenome system for identifying small-molecule inhibitors of Ebola virus replication MR Edwards, C Pietzsch, T Vausselin, ML Shaw, A Bukreyev, CF Basler ACS infectious diseases 1 (8), 380-387, 2015 | 61 | 2015 |
| Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses KM Smith, S Tsimbalyuk, MR Edwards, EM Cross, J Batra, ... Nature communications 9 (1), 3703, 2018 | 55 | 2018 |
| Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses S Chatterjee, P Luthra, E Esaulova, E Agapov, BC Yen, DM Borek, ... Nature microbiology 2 (9), 1-8, 2017 | 45 | 2017 |
| Current status of small molecule drug development for Ebola virus and other filoviruses MR Edwards, CF Basler Current opinion in virology 35, 42-56, 2019 | 43 | 2019 |
| A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication P Luthra, J Liang, CA Pietzsch, S Khadka, MR Edwards, S Wei, S De, ... Antiviral research 150, 193-201, 2018 | 34 | 2018 |
| Structural basis for nuclear import selectivity of pioneer transcription factor SOX2 B Jagga, M Edwards, M Pagin, KM Wagstaff, D Aragão, N Roman, ... Nature Communications 12 (1), 1-11, 2021 | 33 | 2021 |
| VP24-karyopherin alpha binding affinities differ between Ebolavirus species, influencing interferon inhibition and VP24 stability TM Schwarz, MR Edwards, A Diederichs, JB Alinger, DW Leung, ... Journal of virology 91 (4), e01715-16, 2017 | 30 | 2017 |
| Interactions of the Nipah virus P, V, and W proteins across the STAT family of transcription factors TR Keiffer, MJ Ciancanelli, MR Edwards, CF Basler Msphere 5 (6), 10.1128/msphere. 00449-20, 2020 | 28 | 2020 |
| Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses B Johnson, J Li, J Adhikari, MR Edwards, H Zhang, T Schwarz, DW Leung, ... Journal of molecular biology 428 (17), 3483-3494, 2016 | 27 | 2016 |
| Conservation of structure and immune antagonist functions of filoviral VP35 homologs present in microbat genomes MR Edwards, H Liu, RS Shabman, GM Ginell, P Luthra, P Ramanan, ... Cell reports 24 (4), 861-872. e6, 2018 | 22 | 2018 |
| Henipavirus W proteins interact with 14-3-3 to modulate host gene expression MR Edwards, M Hoad, S Tsimbalyuk, AR Menicucci, I Messaoudi, ... Journal of Virology 94 (14), 10.1128/jvi. 00373-20, 2020 | 17 | 2020 |
| Marburg virus VP24 protein relieves suppression of the NF–κB pathway through interaction with Kelch-like ECH-associated protein 1 MR Edwards, CF Basler The Journal of infectious diseases 212 (suppl_2), S154-S159, 2015 | 17 | 2015 |
| The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors S Chiang, T Burch, G Van Domselaar, K Dick, A Radziwon, C Brusnyk, ... Molecular and cellular biochemistry 333, 221-232, 2010 | 15 | 2010 |
