Richard Siegel
Richard Siegel
Novartis Institutes of BioMedical Research
Verified email at novartis.com - Homepage
Title
Cited by
Cited by
Year
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
A Laurence, CM Tato, TS Davidson, Y Kanno, Z Chen, Z Yao, RB Blank, ...
Immunity 26 (3), 371-381, 2007
15952007
Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment
M Lenardo, FKM Chan, F Hornung, H McFarland, R Siegel, J Wang, ...
Annual review of immunology 17 (1), 221-253, 1999
11721999
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
FKM Chan, HJ Chun, L Zheng, RM Siegel, KL Bui, MJ Lenardo
Science 288 (5475), 2351-2354, 2000
10992000
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
RM Siegel, JK Frederiksen, DA Zacharias, FKM Chan, M Johnson, ...
Science 288 (5475), 2354-2357, 2000
7942000
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
HJ Chun, L Zheng, M Ahmad, J Wang, CK Speirs, RM Siegel, JK Dale, ...
Nature 419 (6905), 395-399, 2002
7492002
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
AC Bulua, A Simon, R Maddipati, M Pelletier, H Park, KY Kim, MN Sack, ...
Journal of Experimental Medicine 208 (3), 519-533, 2011
7402011
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
DA Martin, RM Siegel, L Zheng, MJ Lenardo
Journal of Biological Chemistry 273 (8), 4345-4349, 1998
5231998
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
RM Siegel, FKM Chan, HJ Chun, MJ Lenardo
Nature immunology 1 (6), 469-474, 2000
5172000
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, ...
PLoS Genet 6 (2), e1000841, 2010
4052010
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
JB Oliveira, JJ Bleesing, U Dianzani, TA Fleisher, ES Jaffe, MJ Lenardo, ...
Blood 116 (14), e35-e40, 2010
3982010
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction
JR Muppidi, J Tschopp, RM Siegel
Immunity 21 (4), 461-465, 2004
3942004
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells
T Kanno, Y Kanno, RM Siegel, MK Jang, MJ Lenardo, K Ozato
Molecular cell 13 (1), 33-43, 2004
3832004
Caspases at the crossroads of immune-cell life and death
RM Siegel
Nature Reviews Immunology 6 (4), 308-317, 2006
3682006
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ...
Nature genetics 48 (1), 67-73, 2016
3602016
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
AP Gregory, CA Dendrou, KE Attfield, A Haghikia, DK Xifara, F Butter, ...
Nature 488 (7412), 508-511, 2012
3452012
Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis
RM Siegel, DA Martin, L Zheng, SY Ng, J Bertin, J Cohen, MJ Lenardo
The Journal of cell biology 141 (5), 1243-1253, 1998
2801998
Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death
JR Muppidi, RM Siegel
Nature immunology 5 (2), 182-189, 2004
2652004
Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid Protein Precursor
B Passer, L Pellegrini, C Russo, RM Siegel, MJ Lenardo, G Schettini, ...
Journal of Alzheimer's Disease 2 (3-4), 289-301, 2000
2602000
The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
L Wang, JK Yang, V Kabaleeswaran, AJ Rice, AC Cruz, AY Park, Q Yin, ...
Nature structural & molecular biology 17 (11), 1324, 2010
2592010
Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)
AA Lobito, FC Kimberley, JR Muppidi, H Komarow, AJ Jackson, KM Hull, ...
Blood 108 (4), 1320-1327, 2006
2442006
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