| Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ... The Journal of clinical investigation 118 (9), 2008 | 1471 | 2008 |
| Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages SM Melief, E Schrama, MH Brugman, MM Tiemessen, MJ Hoogduijn, ... Stem cells 31 (9), 1980-1991, 2013 | 491 | 2013 |
| Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors U Modlich, S Navarro, D Zychlinski, T Maetzig, S Knoess, MH Brugman, ... Molecular Therapy 17 (11), 1919-1928, 2009 | 473 | 2009 |
| Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein–induced activation of endothelial cells G Valdimarsdottir, MJ Goumans, A Rosendahl, M Brugman, S Itoh, ... Circulation 106 (17), 2263-2270, 2002 | 378 | 2002 |
| Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion TC Luis, BAE Naber, PPC Roozen, MH Brugman, EFE de Haas, ... Cell stem cell 9 (4), 345-356, 2011 | 373 | 2011 |
| Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming E Warlich, J Kuehle, T Cantz, MH Brugman, T Maetzig, M Galla, ... Molecular Therapy 19 (4), 782-789, 2011 | 323 | 2011 |
| Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ... The Journal of clinical investigation 117 (8), 2225-2232, 2007 | 298 | 2007 |
| Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development TC Luis, M Ichii, MH Brugman, P Kincade, FJT Staal Leukemia 26 (3), 414-421, 2012 | 247 | 2012 |
| Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo K Schwarzwaelder, SJ Howe, M Schmidt, MH Brugman, A Deichmann, ... The Journal of clinical investigation 117 (8), 2241-2249, 2007 | 241 | 2007 |
| Resistance of mature T cells to oncogene transformation S Newrzela, K Cornils, Z Li, C Baum, MH Brugman, M Hartmann, J Meyer, ... Blood, The Journal of the American Society of Hematology 112 (6), 2278-2286, 2008 | 240 | 2008 |
| Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis H Holstege, W Pfeiffer, D Sie, M Hulsman, TJ Nicholas, CC Lee, T Ross, ... Genome research 24 (5), 733-742, 2014 | 204 | 2014 |
| Next‐generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3‐ITD or NPM1 mutations F Thol, B Kölking, F Damm, K Reinhardt, JH Klusmann, D Reinhardt, ... Genes, Chromosomes and Cancer 51 (7), 689-695, 2012 | 155 | 2012 |
| Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential F Weerkamp, MRM Baert, MH Brugman, WA Dik, EFE de Haas, TP Visser, ... Blood 107 (8), 3131-3137, 2006 | 141 | 2006 |
| Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16 U Modlich, A Schambach, MH Brugman, DC Wicke, S Knoess, Z Li, ... Leukemia 22 (8), 1519-1528, 2008 | 119 | 2008 |
| Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways OS Kustikova, H Geiger, Z Li, MH Brugman, SM Chambers, CA Shaw, ... Blood 109 (5), 1897-1907, 2007 | 103 | 2007 |
| The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell–specific tumor suppressor for development of lymphomas MM Tiemessen, MRM Baert, T Schonewille, MH Brugman, F Famili, ... PLoS biology 10 (11), e1001430, 2012 | 91 | 2012 |
| Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery M Galla, A Schambach, CS Falk, T Maetzig, J Kuehle, K Lange, ... Nucleic acids research 39 (16), 7147-7160, 2011 | 91 | 2011 |
| Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MMA Verstegen, ... Leukemia 21 (4), 754-763, 2007 | 89 | 2007 |
| Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis OS Kustikova, B Schiedlmeier, MH Brugman, M Stahlhut, S Bartels, Z Li, ... Molecular therapy 17 (9), 1537-1547, 2009 | 86 | 2009 |
| Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity JD Suerth, T Maetzig, MH Brugman, N Heinz, JU Appelt, KB Kaufmann, ... Molecular therapy 20 (5), 1022-1032, 2012 | 82 | 2012 |
Axel SchambachFull Professor, Hannover Medical SchoolVerified email at mh-hannover.de
