noel mcelvaney
noel mcelvaney
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A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation
BW Ramsey, J Davies, NG McElvaney, E Tullis, SC Bell, P Dřevínek, ...
New England Journal of Medicine 365 (18), 1663-1672, 2011
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
RG Crystal, NG McElvaney, MA Rosenfeld, CS Chu, A Mastrangeli, ...
Nature genetics 8 (1), 42-51, 1994
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
H Nakamura, K Yoshimura, NG McElvaney, RG Crystal
The Journal of clinical investigation 89 (5), 1478-1484, 1992
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.
P Birrer, NG McElvaney, A Rüdeberg, CW Sommer, S Liechti-Gallati, ...
American journal of respiratory and critical care medicine 150 (1), 207-213, 1994
Systemic deficiency of glutathione in cystic fibrosis
JH Roum, R Buhl, NG McElvaney, Z Borok, RG Crystal
Journal of applied physiology 75 (6), 2419-2424, 1993
Aerosol α1-antitrypsin treatment for cystic fibrosis
NG McElvaney, RC Hubbard, P Birrer, RG Crystal, MS Chernick, ...
The Lancet 337 (8738), 392-394, 1991
Oxidation of either methionine 351 or methionine 358 in α1-antitrypsin causes loss of anti-neutrophil elastase activity
C Taggart, D Cervantes-Laurean, G Kim, NG McElvaney, N Wehr, J Moss, ...
Journal of Biological Chemistry 275 (35), 27258-27265, 2000
Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial
KR Chapman, JGW Burdon, E Piitulainen, RA Sandhaus, N Seersholm, ...
The Lancet 386 (9991), 360-368, 2015
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant …
NG McElvaney, H Nakamura, P Birrer, CA Hebert, WL Wong, M Alphonso, ...
The Journal of clinical investigation 90 (4), 1296-1301, 1992
Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results
TR Flotte, BC Trapnell, M Humphries, B Carey, R Calcedo, F Rouhani, ...
Human gene therapy 22 (10), 1239-1247, 2011
TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
CM Greene, TP Carroll, SGJ Smith, CC Taggart, J Devaney, S Griffin, ...
The Journal of Immunology 174 (3), 1638-1646, 2005
Association of IL-10 polymorphism with severity of illness in community acquired pneumonia
PM Gallagher, G Lowe, T Fitzgerald, A Bella, CM Greene, NG McElvaney, ...
Thorax 58 (2), 154-156, 2003
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4
JM Devaney, CM Greene, CC Taggart, TP Carroll, SJ O’Neill, ...
FEBS letters 544 (1-3), 129-132, 2003
α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8
DA Bergin, EP Reeves, P Meleady, M Henry, OJ McElvaney, TP Carroll, ...
The Journal of clinical investigation 120 (12), 4236-4250, 2010
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α
IS Afonina, GA Tynan, SE Logue, SP Cullen, M Bots, AU Lüthi, EP Reeves, ...
Molecular cell 44 (2), 265-278, 2011
Innate immunity in cystic fibrosis lung disease
D Hartl, A Gaggar, E Bruscia, A Hector, V Marcos, A Jung, C Greene, ...
Journal of Cystic Fibrosis 11 (5), 363-382, 2012
Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of alpha1-antitrypsin deficiency
NG McElvaney, JK Stoller, AS Buist, UBS Prakash
Chest 111 (2), 394, 1997
Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding
CC Taggart, SA Cryan, S Weldon, A Gibbons, CM Greene, E Kelly, ...
The Journal of experimental medicine 202 (12), 1659-1668, 2005
A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis
RC Hubbard, NG McElvaney, P Birrer, S Shak, WW Robinson, C Jolley, ...
New England Journal of Medicine 326 (12), 812-815, 1992
Inactivation of human β-defensins 2 and 3 by elastolytic cathepsins
CC Taggart, CM Greene, SG Smith, RL Levine, PB McCray, S O’Neill, ...
The Journal of Immunology 171 (2), 931-937, 2003
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