Visualizing the reaction cycle in an iron (II)-and 2-(oxo)-glutarate-dependent hydroxylase AJ Mitchell, NP Dunham, RJ Martinie, JA Bergman, CJ Pollock, K Hu, ... Journal of the American Chemical Society 139 (39), 13830-13836, 2017 | 114 | 2017 |
Two distinct mechanisms for C–C desaturation by Iron (II)-and 2-(oxo) glutarate-dependent oxygenases: Importance of α-heteroatom assistance NP Dunham, W Chang, AJ Mitchell, RJ Martinie, B Zhang, JA Bergman, ... Journal of the American Chemical Society 140 (23), 7116-7126, 2018 | 95 | 2018 |
Nature’s machinery, repurposed: expanding the repertoire of iron-dependent oxygenases NP Dunham, FH Arnold ACS catalysis 10 (20), 12239-12255, 2020 | 92 | 2020 |
AgHalo: a facile fluorogenic sensor to detect drug‐induced proteome stress Y Liu, M Fares, NP Dunham, Z Gao, K Miao, X Jiang, SS Bollinger, ... Angewandte Chemie 129 (30), 8798-8802, 2017 | 88 | 2017 |
The cation− π interaction enables a halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification Y Liu, K Miao, NP Dunham, H Liu, M Fares, AK Boal, X Li, X Zhang Biochemistry 56 (11), 1585-1595, 2017 | 72 | 2017 |
Structure-guided reprogramming of a hydroxylase to halogenate its small molecule substrate AJ Mitchell, NP Dunham, JA Bergman, B Wang, Q Zhu, W Chang, X Liu, ... Biochemistry 56 (3), 441-444, 2017 | 68 | 2017 |
Hydrogen donation but not abstraction by a tyrosine (Y68) during endoperoxide installation by verruculogen synthase (FtmOx1) NP Dunham, JM Del Río Pantoja, B Zhang, LJ Rajakovich, BD Allen, ... Journal of the American Chemical Society 141 (25), 9964-9979, 2019 | 35 | 2019 |
α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC NP Dunham, AJ Mitchell, JM Del Río Pantoja, C Krebs, JM Bollinger Jr, ... Biochemistry 57 (46), 6479-6488, 2018 | 30 | 2018 |
Asymmetric alkylation of ketones catalyzed by engineered TrpB EJ Watkins‐Dulaney, NP Dunham, S Straathof, S Turi, FH Arnold, ... Angewandte Chemie 133 (39), 21582-21587, 2021 | 12 | 2021 |
Mechanistic Investigation of the Diverse Iron and 2-Oxoglutarate Dependent Oxygenase Superfamily NP Dunham The Pennsylvania State University, 2018 | 1 | 2018 |
Efficient Access to β-Branched Noncanonical Amino Acids via Transaminase-Catalyzed Dynamic Kinetic Resolutions Driven by a Lysine Amine Donor N Dunham, R Ray, C Eberle, M Winston, J Newman, Q Gao, Y Cao, ... | | 2024 |
Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron (II)‐and 2‐Oxoglutarate‐dependent Oxygenases JM Bollinger Jr, C Krebs, AK Boal, A Silakov, JC Price, ML Matthews, ... The FASEB Journal 36, 2022 | | 2022 |
Diverse carbene transferase enzyme catalysts derived from a P450 enzyme KC Noah P. Dunham, Daniel J. Wackelin, Andrew Z. Zhou, Zhen Liu US Patent US11525123B2, 2021 | | 2021 |