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Noah P. Dunham
Noah P. Dunham
Senior Scientist, Merck & Co.
Verified email at merck.com
Title
Cited by
Cited by
Year
Visualizing the reaction cycle in an iron (II)-and 2-(oxo)-glutarate-dependent hydroxylase
AJ Mitchell, NP Dunham, RJ Martinie, JA Bergman, CJ Pollock, K Hu, ...
Journal of the American Chemical Society 139 (39), 13830-13836, 2017
1142017
Two distinct mechanisms for C–C desaturation by Iron (II)-and 2-(oxo) glutarate-dependent oxygenases: Importance of α-heteroatom assistance
NP Dunham, W Chang, AJ Mitchell, RJ Martinie, B Zhang, JA Bergman, ...
Journal of the American Chemical Society 140 (23), 7116-7126, 2018
952018
Nature’s machinery, repurposed: expanding the repertoire of iron-dependent oxygenases
NP Dunham, FH Arnold
ACS catalysis 10 (20), 12239-12255, 2020
922020
AgHalo: a facile fluorogenic sensor to detect drug‐induced proteome stress
Y Liu, M Fares, NP Dunham, Z Gao, K Miao, X Jiang, SS Bollinger, ...
Angewandte Chemie 129 (30), 8798-8802, 2017
882017
The cation− π interaction enables a halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification
Y Liu, K Miao, NP Dunham, H Liu, M Fares, AK Boal, X Li, X Zhang
Biochemistry 56 (11), 1585-1595, 2017
722017
Structure-guided reprogramming of a hydroxylase to halogenate its small molecule substrate
AJ Mitchell, NP Dunham, JA Bergman, B Wang, Q Zhu, W Chang, X Liu, ...
Biochemistry 56 (3), 441-444, 2017
682017
Hydrogen donation but not abstraction by a tyrosine (Y68) during endoperoxide installation by verruculogen synthase (FtmOx1)
NP Dunham, JM Del Río Pantoja, B Zhang, LJ Rajakovich, BD Allen, ...
Journal of the American Chemical Society 141 (25), 9964-9979, 2019
352019
α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC
NP Dunham, AJ Mitchell, JM Del Río Pantoja, C Krebs, JM Bollinger Jr, ...
Biochemistry 57 (46), 6479-6488, 2018
302018
Asymmetric alkylation of ketones catalyzed by engineered TrpB
EJ Watkins‐Dulaney, NP Dunham, S Straathof, S Turi, FH Arnold, ...
Angewandte Chemie 133 (39), 21582-21587, 2021
122021
Mechanistic Investigation of the Diverse Iron and 2-Oxoglutarate Dependent Oxygenase Superfamily
NP Dunham
The Pennsylvania State University, 2018
12018
Efficient Access to β-Branched Noncanonical Amino Acids via Transaminase-Catalyzed Dynamic Kinetic Resolutions Driven by a Lysine Amine Donor
N Dunham, R Ray, C Eberle, M Winston, J Newman, Q Gao, Y Cao, ...
2024
Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron (II)‐and 2‐Oxoglutarate‐dependent Oxygenases
JM Bollinger Jr, C Krebs, AK Boal, A Silakov, JC Price, ML Matthews, ...
The FASEB Journal 36, 2022
2022
Diverse carbene transferase enzyme catalysts derived from a P450 enzyme
KC Noah P. Dunham, Daniel J. Wackelin, Andrew Z. Zhou, Zhen Liu
US Patent US11525123B2, 2021
2021
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