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Joseph Spernyak
Joseph Spernyak
Director of Operations, Small Animal BioImaging Resource
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Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA
J Jell, S Merali, ML Hensen, R Mazurchuk, JA Spernyak, P Diegelman, ...
Journal of Biological Chemistry 282 (11), 8404-8413, 2007
1522007
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4–dependent regulation of tumor vasculature
JR Riddell, W Bshara, MT Moser, JA Spernyak, BA Foster, SO Gollnick
Cancer research 71 (5), 1637-1646, 2011
1502011
Iron (II) paraCEST MRI contrast agents
SJ Dorazio, PB Tsitovich, KE Siters, JA Spernyak, JR Morrow
Journal of the American Chemical Society 133 (36), 14154-14156, 2011
1422011
Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
A Sen, ML Capitano, JA Spernyak, JT Schueckler, S Thomas, AK Singh, ...
Cancer research 71 (11), 3872-3880, 2011
1342011
A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states
PB Tsitovich, JA Spernyak, JR Morrow
Angewandte Chemie (International ed. in English) 52 (52), 13997, 2013
1082013
The NiCEST approach: nickel (II) paraCEST MRI contrast agents
AO Olatunde, SJ Dorazio, JA Spernyak, JR Morrow
Journal of the American Chemical Society 134 (45), 18503-18505, 2012
1012012
CoCEST: cobalt (II) amide-appended paraCEST MRI contrast agents
SJ Dorazio, AO Olatunde, JA Spernyak, JR Morrow
Chemical Communications 49 (85), 10025-10027, 2013
942013
Chlorophyll-a analogues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic resonance imaging and photodynamic therapy
G Li, A Slansky, MP Dobhal, LN Goswami, A Graham, Y Chen, P Kanter, ...
Bioconjugate chemistry 16 (1), 32-42, 2005
882005
Light delivery over extended time periods enhances the effectiveness of photodynamic therapy
M Seshadri, DA Bellnier, LA Vaughan, JA Spernyak, R Mazurchuk, ...
Clinical Cancer Research 14 (9), 2796-2805, 2008
842008
Tumor vascular response to photodynamic therapy and the antivascular agent 5, 6-dimethylxanthenone-4-acetic acid: implications for combination therapy
M Seshadri, JA Spernyak, R Mazurchuk, SH Camacho, AR Oseroff, ...
Clinical cancer research 11 (11), 4241-4250, 2005
772005
A Class of FeIII Macrocyclic Complexes with Alcohol Donor Groups as Effective T1 MRI Contrast Agents
EM Snyder, D Asik, SM Abozeid, A Burgio, G Bateman, SG Turowski, ...
Angewandte Chemie 132 (6), 2435-2440, 2020
752020
Metabolic imaging of rat brain during pharmacologically-induced tinnitus
AK Paul, E Lobarinas, R Simmons, D Wack, JC Luisi, J Spernyak, ...
Neuroimage 44 (2), 312-318, 2009
752009
High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer
M Bouvet, J Spernyak, MH Katz, RV Mazurchuk, S Takimoto, R Bernacki, ...
Cancer research 65 (21), 9829-9833, 2005
712005
Fast stereolithography printing of large‐scale biocompatible hydrogel models
N Anandakrishnan, H Ye, Z Guo, Z Chen, KI Mentkowski, JK Lang, ...
Advanced healthcare materials 10 (10), 2002103, 2021
652021
Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia ¡¦
A Bhattacharya, K Tóth, R Mazurchuk, JA Spernyak, HK Slocum, ...
Clinical cancer research 10 (23), 8005-8017, 2004
632004
Gear up for a pH shift: A responsive iron (II) 2-amino-6-picolyl-appended macrocyclic paracest agent that protonates at a pendent group
PB Tsitovich, JM Cox, JA Spernyak, JR Morrow
Inorganic chemistry 55 (22), 12001-12010, 2016
562016
Multifunctional Liposomes for Image‐Guided Intratumoral Chemo‐Phototherapy
D Miranda, K Carter, D Luo, S Shao, J Geng, C Li, U Chitgupi, ...
Advanced healthcare materials 6 (16), 1700253, 2017
542017
Visualizing the acute effects of vascular-targeted therapy in vivo using intravital microscopy and magnetic resonance imaging: correlation with endothelial apoptosis, cytokine ¡¦
M Seshadri, JA Spernyak, PG Maier, RT Cheney, R Mazurchuk, ...
Neoplasia 9 (2), 128-135, 2007
542007
Seven-Coordinate CoII, FeII and Six-Coordinate NiII Amide-Appended Macrocyclic Complexes as ParaCEST Agents in Biological Media
AO Olatunde, JM Cox, MD Daddario, JA Spernyak, JB Benedict, ...
Inorganic Chemistry 53 (16), 8311-8321, 2014
532014
Hexylether derivative of pyropheophorbide-a (HPPH) on conjugating with 3gadolinium (III) aminobenzyldiethylenetriaminepentaacetic acid shows potential for in vivo tumor imaging ¡¦
JA Spernyak, WH White III, M Ethirajan, NJ Patel, L Goswami, Y Chen, ...
Bioconjugate chemistry 21 (5), 828-835, 2010
532010
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