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Gordon Irvine
Gordon Irvine
The University of Texas at Dallas
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Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion
GW Irvine, TBJ Pinter, MJ Stillman
Metallomics 8 (1), 71-81, 2016
542016
Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data
JS Scheller, GW Irvine, MJ Stillman
Dalton transactions 47 (11), 3613-3637, 2018
472018
Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions
JS Scheller, GW Irvine, DL Wong, A Hartwig, MJ Stillman
Metallomics 9 (5), 447-462, 2017
462017
A simple metallothionein-based biosensor for enhanced detection of arsenic and mercury
GW Irvine, SN Tan, MJ Stillman
Biosensors 7 (1), 14, 2017
442017
Cysteine accessibility during As3+ metalation of the ¥á-and ¥â-domains of recombinant human MT1a
GW Irvine, KL Summers, MJ Stillman
Biochemical and Biophysical Research Communications 433 (4), 477-483, 2013
362013
Domain selection in metallothionein 1a: Affinity-controlled mechanisms of zinc binding and cadmium exchange
TBJ Pinter, GW Irvine, MJ Stillman
Biochemistry 54 (32), 5006-5016, 2015
282015
Metalation kinetics of the human ¥á‐metallothionein 1a fragment is dependent on the fluxional structure of the apo‐protein
GW Irvine, KER Duncan, M Gullons, MJ Stillman
Chemistry–A European Journal 21 (3), 1269-1279, 2015
252015
Selective cysteine modification of metal‐free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI‐MS
GW Irvine, M Santolini, MJ Stillman
Protein Science 26 (5), 960-971, 2017
212017
Topographical analysis of As-induced folding of ¥á-MT1a
GW Irvine, MJ Stillman
Biochemical and Biophysical Research Communications 441 (1), 208-213, 2013
182013
Residue modification and mass spectrometry for the investigation of structural and metalation properties of metallothionein and cysteine-rich proteins
GW Irvine, MJ Stillman
International journal of molecular sciences 18 (5), 913, 2017
152017
Cadmium binding mechanisms of isolated domains of human MT isoform 1a: Non-cooperative terminal sites and cooperative cluster sites
GW Irvine, MJ Stillman
Journal of Inorganic Biochemistry 158, 115-121, 2016
132016
Isolated domains of recombinant human apo-metallothionein 1A are folded at neutral pH: a denaturant and heat-induced unfolding study using ESI-MS
GW Irvine, N Korkola, MJ Stillman
Bioscience Reports 38 (4), BSR20180592, 2018
122018
Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion, Metallomics, 2016, 8 (1), 71–81
GW Irvine, TB Pinter, MJ Stillman
9
Formation of oxidative and non‐oxidative dimers in metallothioneins: Implications for charge‐state analysis for structural determination
GW Irvine, L Heinlein, JB Renaud, MW Sumarah, MJ Stillman
Rapid Communications in Mass Spectrometry 31 (24), 2118-2124, 2017
72017
Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn 2+ pumps
MJ Gallenito, GW Irvine, L Zhang, G Meloni
Chemical communications 55 (73), 10844-10847, 2019
62019
Chromatographic separation of similar post-translationally modified metallothioneins reveals the changing conformations of apo-MT upon cysteine alkylation by high resolution LC ¡¦
GW Irvine, MJ Stillman
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1866 (5-6), 589-601, 2018
42018
An overview of the ¡°-omics¡± fields at the forefront of next-generation personalized medicine and fundamental systems biology studies
GW Irvine, S Nguyen
Biomedical Genetics and Genomics 4 (2), 1-6, 2019
32019
Plastic recognition and electrogenic uniport translocation of 1 st-, 2 nd-, and 3 rd-row transition and post-transition metals by primary-active transmembrane P 1B-2-type ¡¦
SS Abeyrathna, NS Abeyrathna, P Basak, GW Irvine, L Zhang, G Meloni
Chemical Science 14 (22), 6059-6078, 2023
12023
Metal Substrate Selectivity and Mechanism of Transport in a Transmembrane Zn‐pump Revealed by in‐vitro Real‐time Transport
S Abeyrathna, N Abeyrathna, G Irvine, P Basak, G Meloni
The FASEB Journal 35, 2021
2021
Metalation and Structural Properties of apo-Metallothioneins
GW Irvine
The University of Western Ontario (Canada), 2017
2017
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