Margarida Amaral
Margarida Amaral
Professor of Molecular Biology, Faculty of Sciences, University of Lisboa
Verified email at - Homepage
Cited by
Cited by
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
PR Sosnay, KR Siklosi, F Van Goor, K Kaniecki, H Yu, N Sharma, ...
Nature genetics 45 (10), 1160-1167, 2013
Progress in therapies for cystic fibrosis
K De Boeck, MD Amaral
The Lancet Respiratory Medicine 4 (8), 662-674, 2016
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei
D Zink, MD Amaral, A Englmann, S Lang, LA Clarke, C Rudolph, F Alt, ...
The Journal of cell biology 166 (6), 815-825, 2004
CFTR modulator theratyping: Current status, gaps and future directions
JP Clancy, CU Cotton, SH Donaldson, GM Solomon, DR VanDevanter, ...
Journal of Cystic Fibrosis 18 (1), 22-34, 2019
Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin
CM Farinha, MD Amaral
Molecular and cellular biology 25 (12), 5242-5252, 2005
New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls
SC Bell, K De Boeck, MD Amaral
Pharmacology & therapeutics 145, 19-34, 2015
CFTR and chaperones: processing and degradation
MD Amaral
Journal of Molecular Neuroscience 23, 41-48, 2004
Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis
AS Ramalho, S Beck, M Meyer, D Penque, GR Cutting, MD Amaral
American journal of respiratory cell and molecular biology 27 (5), 619-627, 2002
Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction
CM Farinha, J King-Underwood, M Sousa, AR Correia, BJ Henriques, ...
Chemistry & biology 20 (7), 943-955, 2013
Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis
MD Amaral, K Kunzelmann
Trends in pharmacological sciences 28 (7), 334-341, 2007
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator …
CM Farinha, P Nogueira, F Mendes, D Penque, MD Amaral
Biochemical Journal 366 (3), 797-806, 2002
Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients
MD Amaral
Journal of internal medicine 277 (2), 155-166, 2015
Processing of CFTR: traversing the cellular maze—how much CFTR needs to go through to avoid cystic fibrosis?
MD Amaral
Pediatric pulmonology 39 (6), 479-491, 2005
CFTR Cl− channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis
S Hirtz, T Gonska, HH Seydewitz, J Thomas, P Greiner, J Kuehr, ...
Gastroenterology 127 (4), 1085-1095, 2004
Epithelial chloride transport by CFTR requires TMEM16A
R Benedetto, J Ousingsawat, P Wanitchakool, Y Zhang, MJ Holtzman, ...
Scientific reports 7 (1), 12397, 2017
Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms
M Roxo-Rosa, Z Xu, A Schmidt, M Neto, Z Cai, CM Soares, DN Sheppard, ...
Proceedings of the National Academy of Sciences 103 (47), 17891-17896, 2006
A genetic screening strategy identifies novel regulators of the proteostasis network
MC Silva, S Fox, M Beam, H Thakkar, MD Amaral, RI Morimoto
PLoS genetics 7 (12), e1002438, 2011
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells
SM Garcia, MO Casanueva, MC Silva, MD Amaral, RI Morimoto
Genes & development 21 (22), 3006-3016, 2007
Magnetic field-assisted DNA hybridisation and simultaneous detection using micron-sized spin-valve sensors and magnetic nanoparticles
DL Graham, HA Ferreira, N Feliciano, PP Freitas, LA Clarke, MD Amaral
Sensors and Actuators B: Chemical 107 (2), 936-944, 2005
Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells
D Penque, F Mendes, S Beck, C Farinha, P Pacheco, P Nogueira, ...
Laboratory investigation 80 (6), 857-868, 2000
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