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Adrian Whitty
Adrian Whitty
Associate Professor of Chemistry, Boston University
Verified email at bu.edu
Title
Cited by
Cited by
Year
The resurgence of covalent drugs
J Singh, RC Petter, TA Baillie, A Whitty
Nature reviews Drug discovery 10 (4), 307-317, 2011
18092011
Small-molecule inhibition of TNF-α
MM He, AS Smith, JD Oslob, WM Flanagan, AC Braisted, A Whitty, ...
Science 310 (5750), 1022-1025, 2005
5652005
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance
R Rawat, A Whitty, PJ Tonge
Proceedings of the National Academy of Sciences 100 (24), 13881-13886, 2003
4512003
Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-β (IFN-β)
L Runkel, W Meier, RB Pepinsky, M Karpusas, A Whitty, K Kimball, ...
Pharmaceutical research 15, 641-649, 1998
4121998
The immunological synapse and CD28-CD80 interactions
SK Bromley, A Iaboni, SJ Davis, A Whitty, JM Green, AS Shaw, A Weiss, ...
Nature immunology 2 (12), 1159-1166, 2001
4052001
How proteins bind macrocycles
EA Villar, D Beglov, S Chennamadhavuni, JA Porco Jr, D Kozakov, ...
Nature chemical biology 10 (9), 723-731, 2014
3952014
Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins
M Sanicola, C Hession, D Worley, P Carmillo, C Ehrenfels, L Walus, ...
Proceedings of the National Academy of Sciences 94 (12), 6238-6243, 1997
3661997
Cooperativity and biological complexity
A Whitty
Nature chemical biology 4 (8), 435-439, 2008
3212008
Structural conservation of druggable hot spots in protein–protein interfaces
D Kozakov, DR Hall, GY Chuang, R Cencic, R Brenke, LE Grove, ...
Proceedings of the National Academy of Sciences 108 (33), 13528-13533, 2011
2712011
Between a rock and a hard place?
A Whitty, G Kumaravel
Nature chemical biology 2 (3), 112-118, 2006
2252006
Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs
A Whitty, M Zhong, L Viarengo, D Beglov, DR Hall, S Vajda
Drug Discovery Today 21 (5), 712-717, 2016
2222016
Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases
J Singh, EM Dobrusin, DW Fry, T Haske, A Whitty, DJ McNamara
Journal of medicinal chemistry 40 (7), 1130-1135, 1997
2091997
Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA
ES Day, TG Cachero, F Qian, Y Sun, D Wen, M Pelletier, YM Hsu, A Whitty
Biochemistry 44 (6), 1919-1931, 2005
2072005
Enhanced potency of human Sonic hedgehog by hydrophobic modification
FR Taylor, D Wen, EA Garber, AN Carmillo, DP Baker, RM Arduini, ...
Biochemistry 40 (14), 4359-4371, 2001
2022001
The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions
MR Arkin, A Whitty
Current opinion in chemical biology 13 (3), 284-290, 2009
1972009
N-terminally PEGylated human interferon-β-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model
DP Baker, EY Lin, KC Lin, M Pellegrini, RC Petter, LL Chen, RM Arduini, ...
Bioconjugate chemistry 17 (1), 179-188, 2006
1862006
Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-β
N Di Clemente, SP Jamin, A Lugovskoy, P Carmillo, C Ehrenfels, ...
Molecular endocrinology 24 (11), 2193-2206, 2010
1702010
The structure of human interferon-β: implications for activity
M Karpusas, A Whitty, L Runkel, P Hochman
Cellular and Molecular Life Sciences CMLS 54, 1203-1216, 1998
1631998
Relationship between hot spot residues and ligand binding hot spots in protein–protein interfaces
BS Zerbe, DR Hall, S Vajda, A Whitty, D Kozakov
Journal of chemical information and modeling 52 (8), 2236-2244, 2012
1292012
Cryptic binding sites on proteins: definition, detection, and druggability
S Vajda, D Beglov, AE Wakefield, M Egbert, A Whitty
Current opinion in chemical biology 44, 1-8, 2018
1282018
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