Jim A Searles
Jim A Searles
Independent Consultant
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The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelf
JA Searles, JF Carpenter, TW Randolph
Journal of pharmaceutical sciences 90 (7), 860-871, 2001
Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization
JA Searles, JF Carpenter, TW Randolph
Journal of pharmaceutical sciences 90 (7), 872-887, 2001
Development and optimization of the freeze-drying processes
F Jameel, J Searles
Formulation and process development strategies for manufacturing …, 2010
Elements of quality by design in development and scale-up of freeze-dried parenterals
S Nail, J Searles
Biopharm international 21 (1), 40–45-40–45, 2008
Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant Chinese hamster ovary cells
JA Searles, P Todd, DS Kompala
Biotechnology progress 10 (2), 198-206, 1994
Recommended best practices for process monitoring instrumentation in pharmaceutical freeze drying—2017
S Nail, S Tchessalov, E Shalaev, A Ganguly, E Renzi, F Dimarco, ...
AAPS PharmSciTech 18, 2379-2393, 2017
Freezing and annealing phenomena in lyophilization
JA Searles
Freeze-drying/lyophilization of pharmaceutical and biological products 3rd …, 2010
Observation and implications of sonic water vapor flow during freeze-drying
J Searles
American Pharmaceutical Review 7, 58-69, 2004
Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals
RE Sievers, BP Quinn, SP Cape, JA Searles, CS Braun, P Bhagwat, ...
The Journal of supercritical fluids 42 (3), 385-391, 2007
Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation
KO Kisich, MP Higgins, I Park, SP Cape, L Lindsay, DJ Bennett, S Winston, ...
Vaccine 29 (5), 905-912, 2011
Freezing and annealing phenomena in lyophilization: effects upon primary drying rate, morphology, and heterogeneity
TW Randolph, JA Searles
American Pharmaceutical Review 5, 40-47, 2002
Alternatives to Vial Lyophilization
J Searles, M Cherian
Lyophilized Biologics and Vaccines: Modality-Based Approaches, 257-271, 2015
Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor
FJ Muzzio, DR Unger, M Liu, J Bramble, J Searles, P Fahnestock
Biotechnology and Bioengineering 63 (2), 185-196, 1999
Effects of chamber pressure and partial pressure of water vapor on secondary drying in lyophilization
JA Searles, S Aravapalli, C Hodge
AAPS PharmSciTech 18 (7), 2808-2813, 2017
Perfusion culture of suspended CHO cells employing inclined sedimentation
JA Searles, P Todd, DS Kompala
Animal cell technology, 240-242, 1994
Challenges and Considerations for New Technology Implementation and Synergy with Development of Process Analytical Technologies (PAT)
H Stamato, J Searles
Drying Technologies for Biotechnology and Pharmaceutical Applications, 347-354, 2020
Method of improved mixing in roller bottles
JL Bramble, FJ Muzzio, JA Searles
US Patent 6,096,544, 2000
Primary Drying Rate Heterogeneity During Pharmaceutical Lyophilization
JA Searles, JF Carpenter, TW Randolph
American Pharmaceutical Review 3, 16-24, 2000
Stress factors in protein drug product manufacturing and their impact on product quality
TK Das, A Sreedhara, JD Colandene, DK Chou, V Filipe, C Grapentin, ...
Journal of Pharmaceutical Sciences 111 (4), 868-886, 2022
Spray drying of biopharmaceuticals and vaccines
J Searles, G Mohan
Formulation and Process Development Strategies for Manufacturing …, 2010
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