| The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelf JA Searles, JF Carpenter, TW Randolph Journal of pharmaceutical sciences 90 (7), 860-871, 2001 | 449 | 2001 |
| Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization JA Searles, JF Carpenter, TW Randolph Journal of pharmaceutical sciences 90 (7), 872-887, 2001 | 354 | 2001 |
| Development and optimization of the freeze-drying processes F Jameel, J Searles Formulation and process development strategies for manufacturing …, 2010 | 111* | 2010 |
| Elements of quality by design in development and scale-up of freeze-dried parenterals S Nail, J Searles Biopharm international 21 (1), 40–45-40–45, 2008 | 97 | 2008 |
| Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant Chinese hamster ovary cells JA Searles, P Todd, DS Kompala Biotechnology progress 10 (2), 198-206, 1994 | 88 | 1994 |
| Recommended best practices for process monitoring instrumentation in pharmaceutical freeze drying—2017 S Nail, S Tchessalov, E Shalaev, A Ganguly, E Renzi, F Dimarco, ... AAPS PharmSciTech 18, 2379-2393, 2017 | 79 | 2017 |
| Freezing and annealing phenomena in lyophilization JA Searles Freeze-drying/lyophilization of pharmaceutical and biological products 3rd …, 2010 | 79* | 2010 |
| Observation and implications of sonic water vapor flow during freeze-drying J Searles American Pharmaceutical Review 7, 58-69, 2004 | 66 | 2004 |
| Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals RE Sievers, BP Quinn, SP Cape, JA Searles, CS Braun, P Bhagwat, ... The Journal of supercritical fluids 42 (3), 385-391, 2007 | 47 | 2007 |
| Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation KO Kisich, MP Higgins, I Park, SP Cape, L Lindsay, DJ Bennett, S Winston, ... Vaccine 29 (5), 905-912, 2011 | 44 | 2011 |
| Freezing and annealing phenomena in lyophilization: effects upon primary drying rate, morphology, and heterogeneity TW Randolph, JA Searles American Pharmaceutical Review 5, 40-47, 2002 | 28 | 2002 |
| Alternatives to Vial Lyophilization J Searles, M Cherian Lyophilized Biologics and Vaccines: Modality-Based Approaches, 257-271, 2015 | 22* | 2015 |
| Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor FJ Muzzio, DR Unger, M Liu, J Bramble, J Searles, P Fahnestock Biotechnology and Bioengineering 63 (2), 185-196, 1999 | 21 | 1999 |
| Effects of chamber pressure and partial pressure of water vapor on secondary drying in lyophilization JA Searles, S Aravapalli, C Hodge AAPS PharmSciTech 18 (7), 2808-2813, 2017 | 12 | 2017 |
| Perfusion culture of suspended CHO cells employing inclined sedimentation JA Searles, P Todd, DS Kompala Animal cell technology, 240-242, 1994 | 11 | 1994 |
| Challenges and Considerations for New Technology Implementation and Synergy with Development of Process Analytical Technologies (PAT) H Stamato, J Searles Drying Technologies for Biotechnology and Pharmaceutical Applications, 347-354, 2020 | 10* | 2020 |
| Method of improved mixing in roller bottles JL Bramble, FJ Muzzio, JA Searles US Patent 6,096,544, 2000 | 7 | 2000 |
| Primary Drying Rate Heterogeneity During Pharmaceutical Lyophilization JA Searles, JF Carpenter, TW Randolph American Pharmaceutical Review 3, 16-24, 2000 | 7 | 2000 |
| Stress factors in protein drug product manufacturing and their impact on product quality TK Das, A Sreedhara, JD Colandene, DK Chou, V Filipe, C Grapentin, ... Journal of Pharmaceutical Sciences 111 (4), 868-886, 2022 | 6 | 2022 |
| Spray drying of biopharmaceuticals and vaccines J Searles, G Mohan Formulation and Process Development Strategies for Manufacturing …, 2010 | 6 | 2010 |
TW RandolphDepartment of Chemical and Biological Engineering, University of Colorado, BoulderVerified email at colorado.edu
