A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex L Brzozowski, A.M., Derewenda, U., Derewenda, Z.S., Dodson, G., Lawson, D ... Nature 351, 491-497, 1991 | 1379 | 1991 |
The future impact of industrial lipases F Björkling, SE Godtfredsen, O Kirk Trends in Biotechnology 9 (1), 360-363, 1991 | 346 | 1991 |
Lipase catalyzed synthesis of peroxycarboxylic acids and lipase mediated oxidations. F Björkling, H Frykman, SE Godtfredsen, O Kirk Tetrahedron 48 (22), 4587-4592, 1992 | 278 | 1992 |
Enzyme catalysed preparation of 6-O-acylglucopyranosides K Adelhorst, F Björkling, SE Godtfredsen, O Kirk Synthesis 1990 (02), 112-115, 1990 | 197 | 1990 |
Lipase-mediated formation of peroxycarboxylic acids used in catalytic epoxidation of alkenes F Björkling, SE Godtfredsen, O Kirk Journal of the Chemical Society, Chemical Communications, 1301-1303, 1990 | 180 | 1990 |
Rapid synthesis of aryl azides from aryl halides under mild conditions J Andersen, U Madsen, F Björkling, X Liang Synlett 2005 (14), 2209-2213, 2005 | 174 | 2005 |
Anticancer agent CHS-828 inhibits cellular synthesis of NAD UH Olesen, MK Christensen, F Björkling, M Jäättelä, PB Jensen, ... Biochemical and biophysical research communications 367 (4), 799-804, 2008 | 170 | 2008 |
A highly selective enzyme-catalysed esterification of simple glucosides F Björkling, SE Godtfredsen, O Kirk Journal of the Chemical Society, Chemical Communications, 934-935, 1989 | 152 | 1989 |
Enzyme catalysed hydrolysis of dialkylated propanedioic acid diesters, chain length dependent reversal of enantioselectivity F Björkling, J Boutelje, S Gatenbeck, K Hult, T Norin, P Szmulik Tetrahedron 41 (7), 1347-1352, 1985 | 127 | 1985 |
Fatty acid specificity in lipase-catalyzed synthesis of glucoside esters O Kirk, F Björkling, SE Godtfredsen, TO Larsen Biocatalysis 6 (2), 127-134, 1992 | 123 | 1992 |
Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy E Martin, AV Thougaard, M Grauslund, PB Jensen, F Bjorkling, ... Toxicology 255 (1-2), 72-79, 2009 | 120 | 2009 |
Recombinant human PPAR-β/δ ligand-binding domain is locked in an activated conformation by endogenous fatty acids SA Fyffe, MS Alphey, L Buetow, TK Smith, MAJ Ferguson, MD Sørensen, ... Journal of molecular biology 356 (4), 1005-1013, 2006 | 105 | 2006 |
Synthesis and structure− activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity ER Ottosen, MD Sørensen, F Björkling, T Skak-Nielsen, MS Fjording, ... Journal of medicinal chemistry 46 (26), 5651-5662, 2003 | 99 | 2003 |
Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity MD Sørensen, LKA Blæhr, MK Christensen, T Høyer, S Latini, ... Bioorganic & medicinal chemistry 11 (24), 5461-5484, 2003 | 86 | 2003 |
Novel cyanoguanidines with potent oral antitumour activity C Schou, ER Ottosen, HJ Petersen, F Björkling, S Latini, PV Hjarnaa, ... Bioorganic & Medicinal Chemistry Letters 7 (24), 3095-3100, 1997 | 70 | 1997 |
EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828 E Binderup, F Björkling, PV Hjarnaa, S Latini, B Baltzer, M Carlsen, ... Bioorganic & medicinal chemistry letters 15 (10), 2491-2494, 2005 | 64 | 2005 |
Synthesis and antitumor effect in vitro and in vivo of substituted 1, 3-dihydroindole-2-ones MK Christensen, KD Erichsen, C Trojel-Hansen, J Tjørnelund, SJ Nielsen, ... Journal of medicinal chemistry 53 (19), 7140-7145, 2010 | 61 | 2010 |
Lipase inhibitors S Patkar, F Bjorkling Lipases—their structure, biochemistry and application. Cambridge University …, 1994 | 56 | 1994 |
Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase UH Olesen, JG Petersen, A Garten, W Kiess, J Yoshino, SI Imai, ... BMC cancer 10, 1-13, 2010 | 55 | 2010 |
Enzyme catalysed hydrolysis of dialkylated propanedioic acid diesters synthesis of optically pure (S)-α-methylphenylalanine,(S)-α-methyl-tyrosine and (S)-α-methyl-3, 4 … F Björkling, J Boutelie, S Gatenbeck, K Hult, T Norin Tetrahedron Letters 26 (40), 4957-4958, 1985 | 51 | 1985 |