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Hugo M. Botelho
Hugo M. Botelho
BioISI - Faculdade de Ciências, Universidade de Lisboa
Verified email at fc.ul.pt - Homepage
Title
Cited by
Cited by
Year
Metal ions as modulators of protein conformation and misfolding in neurodegeneration
SS Leal, HM Botelho, CM Gomes
Coordination Chemistry Reviews 256 (19-20), 2253-2270, 2012
1752012
Natural and amyloid self‐assembly of S100 proteins: structural basis of functional diversity
G Fritz, HM Botelho, LA Morozova‐Roche, CM Gomes
The FEBS journal 277 (22), 4578-4590, 2010
1562010
Correction of a cystic fibrosis splicing mutation by antisense oligonucleotides
S Igreja, LA Clarke, HM Botelho, L Marques, MD Amaral
Human mutation 37 (2), 209-215, 2016
882016
Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery
HM Botelho, I Uliyakina, NT Awatade, MC Proença, C Tischer, L Sirianant, ...
Scientific reports 5 (1), 9038, 2015
742015
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ...
Science advances 4 (6), eaaq1702, 2018
672018
Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators
LA Clarke, HM Botelho, L Sousa, AO Falcao, MD Amaral
Genomics 106 (5), 268-277, 2015
472015
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation
HM Botelho, SS Leal, I Cardoso, K Yanamandra, LA Morozova-Roche, ...
Journal of Biological Chemistry 287 (50), 42233-42242, 2012
452012
Metal ions modulate the folding and stability of the tumor suppressor protein S100A2
HM Botelho, M Koch, G Fritz, CM Gomes
The FEBS journal 276 (6), 1776-1786, 2009
422009
R560S: a class II CFTR mutation that is not rescued by current modulators
NT Awatade, S Ramalho, IAL Silva, V Felício, HM Botelho, E de Poel, ...
Journal of Cystic Fibrosis 18 (2), 182-189, 2019
352019
A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic
JR Lérias, MC Pinto, HM Botelho, NT Awatade, MC Quaresma, IAL Silva, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 421-431, 2018
352018
Intrinsically Disordered and Aggregation Prone Regions Underlie β-Aggregation in S100 Proteins
CMG SB Carvalho, HM Botelho, SS Leal, I Cardoso, G
PLoS One 8, e76629, 2013
332013
The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme
A Veith, HM Botelho, F Kindinger, CM Gomes, A Kletzin
Journal of bacteriology 194 (3), 677-685, 2012
322012
Analysis of S100 oligomers and amyloids
HM Botelho, G Fritz, CM Gomes
Amyloid Proteins: Methods and Protocols, 373-386, 2012
312012
CFTR processing, trafficking and interactions
MD Amaral, DM Hutt, V Tomati, HM Botelho, N Pedemonte
Journal of Cystic Fibrosis 19, S33-S36, 2020
262020
Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor Ump1
B Sá-Moura, AM Simões, J Fraga, H Fernandes, IA Abreu, HM Botelho, ...
Computational and structural biotechnology journal 7 (8), e201304006, 2013
252013
Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum
JD Santos, S Canato, AS Carvalho, HM Botelho, K Aloria, MD Amaral, ...
Cells 8 (4), 353, 2019
242019
CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
SH Lim, J Snider, L Birimberg‐Schwartz, W Ip, JC Serralha, HM Botelho, ...
Molecular Systems Biology 18 (2), e10629, 2022
232022
A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability
V Prosinecki, HM Botelho, S Francese, G Mastrobuoni, G Moneti, T Urich, ...
Journal of proteome research 5 (10), 2720-2726, 2006
172006
Investigating alternative transport of integral plasma membrane proteins from the er to the golgi: lessons from the cystic fibrosis transmembrane conductance regulator (CFTR)
MD Amaral, CM Farinha, P Matos, HM Botelho
Unconventional Protein Secretion: Methods and Protocols, 105-126, 2016
132016
Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A> G
IAL Silva, T Doušová, S Ramalho, R Centeio, LA Clarke, V Railean, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (11), 165905, 2020
122020
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