Lars Olsen

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Flemming Steen JørgensenProfessor, Department of Drug Design and Pharmacology, University of CopenhagenVerified email at sund.ku.dk
Patrik RydbergAssociate Director, Computational Chemmistry, Optibrium Ltd.Verified email at optibrium.com
Michael GajhedeProfessor i proteinkrystallografi, Københavns UniversitetVerified email at sund.ku.dk
Lars HemmingsenDepartment of Chemistry, University of CopenhagenVerified email at chem.ku.dk
Anders Skov KristensenUniversity of CopenhagenVerified email at sund.ku.dk
Vasanthanathan PoongavanamUppsala UniversityVerified email at kemi.uu.se
Kasper B. HansenAssociate Professor, University of MontanaVerified email at mso.umt.edu
Kristian StrømgaardProfessor i kemisk biologi, Københavns UniversitetVerified email at sund.ku.dk
Silvia BonomoAstraZenecaVerified email at astrazeneca.com
Jesper L. KristensenUniversity of CopenhagenVerified email at sund.ku.dk
Marco van de WeertAssociate Professor in Biologics formulation, University of CopenhagenVerified email at sund.ku.dk
Curt BrenemanDean of Science, Professor of Chemistry & Chemical Biology, Rensselaer Polytechnic InstituteVerified email at rpi.edu
Rasmus Prætorius ClausenUniversity of CopenhagenVerified email at sund.ku.dk
osman mirzaAssociate professor in Medicinal chemistryVerified email at sund.ku.dk
Carsten Uhd NielsenDepartment of Physics, Chemistry and Pharmacy, Faculty of Sciences, University of Southern DenmarkVerified email at sdu.dk
Bente SteffansenProfessor in Pharmaceutical Sciences, University of Southern DenmarkVerified email at sdu.dk
Per-Ola NorrbyPrincipal Scientist, AstraZenecaVerified email at astrazeneca.com
Kurt V. MikkelsenProfessor of Theoretical Chemistry, Department of Chemistry, University of CopenhagenVerified email at chem.ku.dk
Stephan P. A. SauerProfessor, Department of Chemistry, University of CopenhagenVerified email at kiku.dk
Birger BrodinProfessor, CNS drug delivery, University of CopenhagenVerified email at sund.ku.dk

Lars Olsen

Department of Drug Design and Pharmacology, University of Copenhagen

Verified email at novozymes.com

Cytochrome P450 Histone Demethylase Ionotropic Glutamate Receptors SMARTCyp thermodynamics


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SMARTCyp: a 2D method for prediction of cytochrome P450-mediated drug metabolism P Rydberg, DE Gloriam, J Zaretzki, C Breneman, L Olsen ACS medicinal chemistry letters 1 (3), 96-100, 2010	301	2010
Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities M Groenning, L Olsen, M van de Weert, JM Flink, S Frokjaer, ... Journal of structural biology 158 (3), 358-369, 2007	295	2007
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013	165	2013
Ionotropic glutamate-like receptor δ2 binds D-serine and glycine P Naur, KB Hansen, AS Kristensen, SM Dravid, DS Pickering, L Olsen, ... Proceedings of the National Academy of Sciences 104 (35), 14116-14121, 2007	158	2007
The SMARTCyp cytochrome P450 metabolism prediction server P Rydberg, DE Gloriam, L Olsen Bioinformatics 26 (23), 2988-2989, 2010	157	2010
Prediction of activation energies for hydrogen abstraction by cytochrome P450 L Olsen, P Rydberg, TH Rod, U Ryde Journal of medicinal chemistry 49 (22), 6489-6499, 2006	134	2006
Location of the antidepressant binding site in the serotonin transporter J Andersen, O Taboureau, KB Hansen, L Olsen, J Egebjerg, ... Journal of Biological Chemistry 284 (15), 10276-10284, 2009	128	2009
Quantum chemical geometry optimizations in proteins using crystallographic raw data U Ryde, L Olsen, K Nilsson Journal of computational chemistry 23 (11), 1058-1070, 2002	121	2002
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection V Foderà, M Groenning, V Vetri, F Librizzi, S Spagnolo, C Cornett, L Olsen, ... The Journal of Physical Chemistry B 112 (47), 15174-15181, 2008	118	2008
Classification of cytochrome P450 1A2 inhibitors and noninhibitors by machine learning techniques P Vasanthanathan, O Taboureau, C Oostenbrink, NPE Vermeulen, ... Drug Metabolism and Disposition 37 (3), 658-664, 2009	116	2009
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter J Andersen, L Olsen, KB Hansen, O Taboureau, FS Jørgensen, ... Journal of Biological Chemistry 285 (3), 2051-2063, 2010	108	2010
Prediction of cytochrome P450 mediated metabolism L Olsen, C Oostenbrink, FS Jørgensen Advanced drug delivery reviews 86, 61-71, 2015	103	2015
Sulfoxide, sulfur, and nitrogen oxidation and dealkylation by cytochrome P450 P Rydberg, U Ryde, L Olsen Journal of Chemical Theory and Computation 4 (8), 1369-1377, 2008	93	2008
RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes J Zaretzki, P Rydberg, C Bergeron, KP Bennett, L Olsen, CM Breneman Journal of chemical information and modeling 52 (6), 1637-1659, 2012	90	2012
Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands P Vasanthanathan, J Hritz, O Taboureau, L Olsen, F Steen Jørgensen, ... Journal of chemical information and modeling 49 (1), 43-52, 2009	87	2009
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4‐pyridine‐dicarboxylic acid as an in vitro and … LH Kristensen, AL Nielsen, C Helgstrand, M Lees, P Cloos, JS Kastrup, ... The FEBS journal 279 (11), 1905-1914, 2012	85	2012
Evaluation of carbohydrate molecular mechanical force fields by quantum mechanical calculations L Hemmingsen, DE Madsen, AL Esbensen, L Olsen, SB Engelsen Carbohydrate research 339 (5), 937-948, 2004	80	2004
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design L Olsen, S Jost, HW Adolph, I Pettersson, L Hemmingsen, FS Jørgensen Bioorganic & medicinal chemistry 14 (8), 2627-2635, 2006	68	2006
Design and synthesis of highly potent and plasma‐stable dimeric inhibitors of the PSD‐95–NMDA receptor interaction A Bach, CN Chi, GF Pang, L Olsen, AS Kristensen, P Jemth, ... Angewandte Chemie International Edition 48 (51), 9685-9689, 2009	67	2009
Binding of D‐ and L‐captopril inhibitors to metallo‐β‐lactamase studied by polarizable molecular mechanics and quantum mechanics J Antony, N Gresh, L Olsen, L Hemmingsen, CJ Schofield, R Bauer Journal of computational chemistry 23 (13), 1281-1296, 2002	65	2002

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