Lars Olsen
Lars Olsen
Department of Drug Design and Pharmacology, University of Copenhagen
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SMARTCyp: a 2D method for prediction of cytochrome P450-mediated drug metabolism
P Rydberg, DE Gloriam, J Zaretzki, C Breneman, L Olsen
ACS medicinal chemistry letters 1 (3), 96-100, 2010
Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities
M Groenning, L Olsen, M van de Weert, JM Flink, S Frokjaer, ...
Journal of structural biology 158 (3), 358-369, 2007
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
Ionotropic glutamate-like receptor δ2 binds D-serine and glycine
P Naur, KB Hansen, AS Kristensen, SM Dravid, DS Pickering, L Olsen, ...
Proceedings of the National Academy of Sciences 104 (35), 14116-14121, 2007
The SMARTCyp cytochrome P450 metabolism prediction server
P Rydberg, DE Gloriam, L Olsen
Bioinformatics 26 (23), 2988-2989, 2010
Prediction of activation energies for hydrogen abstraction by cytochrome P450
L Olsen, P Rydberg, TH Rod, U Ryde
Journal of medicinal chemistry 49 (22), 6489-6499, 2006
Location of the antidepressant binding site in the serotonin transporter
J Andersen, O Taboureau, KB Hansen, L Olsen, J Egebjerg, ...
Journal of Biological Chemistry 284 (15), 10276-10284, 2009
Quantum chemical geometry optimizations in proteins using crystallographic raw data
U Ryde, L Olsen, K Nilsson
Journal of computational chemistry 23 (11), 1058-1070, 2002
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection
V Foderà, M Groenning, V Vetri, F Librizzi, S Spagnolo, C Cornett, L Olsen, ...
The Journal of Physical Chemistry B 112 (47), 15174-15181, 2008
Classification of cytochrome P450 1A2 inhibitors and noninhibitors by machine learning techniques
P Vasanthanathan, O Taboureau, C Oostenbrink, NPE Vermeulen, ...
Drug Metabolism and Disposition 37 (3), 658-664, 2009
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter
J Andersen, L Olsen, KB Hansen, O Taboureau, FS Jørgensen, ...
Journal of Biological Chemistry 285 (3), 2051-2063, 2010
Prediction of cytochrome P450 mediated metabolism
L Olsen, C Oostenbrink, FS Jørgensen
Advanced drug delivery reviews 86, 61-71, 2015
Sulfoxide, sulfur, and nitrogen oxidation and dealkylation by cytochrome P450
P Rydberg, U Ryde, L Olsen
Journal of Chemical Theory and Computation 4 (8), 1369-1377, 2008
RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes
J Zaretzki, P Rydberg, C Bergeron, KP Bennett, L Olsen, CM Breneman
Journal of chemical information and modeling 52 (6), 1637-1659, 2012
Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands
P Vasanthanathan, J Hritz, O Taboureau, L Olsen, F Steen Jørgensen, ...
Journal of chemical information and modeling 49 (1), 43-52, 2009
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4‐pyridine‐dicarboxylic acid as an in vitro and …
LH Kristensen, AL Nielsen, C Helgstrand, M Lees, P Cloos, JS Kastrup, ...
The FEBS journal 279 (11), 1905-1914, 2012
Evaluation of carbohydrate molecular mechanical force fields by quantum mechanical calculations
L Hemmingsen, DE Madsen, AL Esbensen, L Olsen, SB Engelsen
Carbohydrate research 339 (5), 937-948, 2004
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design
L Olsen, S Jost, HW Adolph, I Pettersson, L Hemmingsen, FS Jørgensen
Bioorganic & medicinal chemistry 14 (8), 2627-2635, 2006
Design and synthesis of highly potent and plasma‐stable dimeric inhibitors of the PSD‐95–NMDA receptor interaction
A Bach, CN Chi, GF Pang, L Olsen, AS Kristensen, P Jemth, ...
Angewandte Chemie International Edition 48 (51), 9685-9689, 2009
Binding of D‐ and L‐captopril inhibitors to metallo‐β‐lactamase studied by polarizable molecular mechanics and quantum mechanics
J Antony, N Gresh, L Olsen, L Hemmingsen, CJ Schofield, R Bauer
Journal of computational chemistry 23 (13), 1281-1296, 2002
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