|mTOR: from growth signal integration to cancer, diabetes and ageing|
R Zoncu, A Efeyan, DM Sabatini
Nature reviews Molecular cell biology 12 (1), 21-35, 2011
|Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids|
Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini
Cell 141 (2), 290-303, 2010
|mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase|
R Zoncu, L Bar-Peled, A Efeyan, S Wang, Y Sancak, DM Sabatini
Science 334 (6056), 678-683, 2011
|A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB|
C Settembre, R Zoncu, DL Medina, F Vetrini, S Erdin, SU Erdin, T Huynh, ...
The EMBO journal 31 (5), 1095-1108, 2012
|Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1|
L Bar-Peled, LD Schweitzer, R Zoncu, DM Sabatini
Cell 150 (6), 1196-1208, 2012
|Origin of GABAergic neurons in the human neocortex|
K Letinic, R Zoncu, P Rakic
Nature 417 (6889), 645-649, 2002
|Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1|
S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ...
Science 347 (6218), 188-194, 2015
|Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling|
G Sahay, W Querbes, C Alabi, A Eltoukhy, S Sarkar, C Zurenko, ...
Nature biotechnology 31 (7), 653-658, 2013
|Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism|
RM Perera, S Stoykova, BN Nicolay, KN Ross, J Fitamant, M Boukhali, ...
Nature 524 (7565), 361-365, 2015
|Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin|
G Di Paolo, L Pellegrini, K Letinic, G Cestra, R Zoncu, S Voronov, ...
Nature 420 (6911), 85-89, 2002
|Amino acids and mTORC1: from lysosomes to disease|
A Efeyan, R Zoncu, DM Sabatini
Trends in molecular medicine 18 (9), 524-533, 2012
|The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1|
ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ...
Molecular cell 52 (4), 495-505, 2013
|The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis|
K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, ...
Nature 575 (7784), 688-692, 2019
|Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness|
P Katajisto, J Döhla, CL Chaffer, N Pentinmikko, N Marjanovic, S Iqbal, ...
Science 348 (6232), 340-343, 2015
|Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival|
A Efeyan, R Zoncu, S Chang, I Gumper, H Snitkin, RL Wolfson, O Kirak, ...
Nature 493 (7434), 679-683, 2013
|A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes|
R Zoncu, RM Perera, DM Balkin, M Pirruccello, D Toomre, P De Camilli
Cell 136 (6), 1110-1121, 2009
|The lysosome as a cellular centre for signalling, metabolism and quality control|
RE Lawrence, R Zoncu
Nature cell biology 21 (2), 133-142, 2019
|Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4, 5-bisphosphate|
R Zoncu, RM Perera, R Sebastian, F Nakatsu, H Chen, T Balla, G Ayala, ...
Proceedings of the National Academy of Sciences 104 (10), 3793-3798, 2007
|The lysosome as a regulatory hub|
RM Perera, R Zoncu
Annual review of cell and developmental biology 32, 223-253, 2016
|A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway|
KS Erdmann, Y Mao, HJ McCrea, R Zoncu, S Lee, S Paradise, ...
Developmental cell 13 (3), 377-390, 2007