Gergely L. Lukacs
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Size-dependent DNA mobility in cytoplasm and nucleus
GL Lukacs, P Haggie, O Seksek, D Lechardeur, N Freedman, ...
Journal of biological chemistry 275 (3), 1625-1629, 2000
Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer
D Lechardeur, KJ Sohn, M Haardt, PB Joshi, M Monck, RW Graham, ...
Gene therapy 6 (4), 482-497, 1999
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects
ME Egan, M Pearson, SA Weiner, V Rajendran, D Rubin, ...
Science 304 (5670), 600-602, 2004
Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening
N Pedemonte, GL Lukacs, K Du, E Caci, O Zegarra-Moran, LJV Galietta, ...
The Journal of clinical investigation 115 (9), 2564-2571, 2005
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
G Veit, RG Avramescu, AN Chiang, SA Houck, Z Cai, KW Peters, JS Hong, ...
Molecular biology of the cell 27 (3), 424-433, 2016
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.
GL Lukacs, A Mohamed, N Kartner, XB Chang, JR Riordan, S Grinstein
The EMBO journal 13 (24), 6076-6086, 1994
Peripheral protein quality control removes unfolded CFTR from the plasma membrane
T Okiyoneda, H Barrière, M Bagdány, WM Rabeh, K Du, J Höhfeld, ...
Science 329 (5993), 805-810, 2010
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on …
GL Lukacs, XB Chang, C Bear, N Kartner, A Mohamed, JR Riordan, ...
Journal of Biological Chemistry 268 (29), 21592-21598, 1993
Mechanism-based corrector combination restores ΔF508-CFTR folding and function
T Okiyoneda, G Veit, JF Dekkers, M Bagdany, N Soya, H Xu, A Roldan, ...
Nature chemical biology 9 (7), 444-454, 2013
CFTR: folding, misfolding and correcting the ΔF508 conformational defect
GL Lukacs, AS Verkman
Trends in molecular medicine 18 (2), 81-91, 2012
Intracellular routing of plasmid DNA during non-viral gene transfer
D Lechardeur, AS Verkman, GL Lukacs
Advanced drug delivery reviews 57 (5), 755-767, 2005
The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR
K Du, M Sharma, GL Lukacs
Nature structural & molecular biology 12 (1), 17-25, 2005
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
M Sharma, F Pampinella, C Nemes, M Benharouga, J So, K Du, ...
The Journal of cell biology 164 (6), 923-933, 2004
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function
WM Rabeh, F Bossard, H Xu, T Okiyoneda, M Bagdany, CM Mulvihill, ...
Cell 148 (1), 150-163, 2012
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression
G Veit, RG Avramescu, D Perdomo, PW Phuan, M Bagdany, PM Apaja, ...
Science translational medicine 6 (246), 246ra97-246ra97, 2014
C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis: a novel class of mutation
M Haardt, M Benharouga, D Lechardeur, N Kartner, GL Lukacs
Journal of Biological Chemistry 274 (31), 21873-21877, 1999
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
DM Hutt, D Herman, APC Rodrigues, S Noel, JM Pilewski, J Matteson, ...
Nature chemical biology 6 (1), 25-33, 2010
Intracellular barriers to non-viral gene transfer
D Lechardeur, GL Lukacs
Current gene therapy 2 (2), 183-194, 2002
Phagosomal acidification is mediated by a vacuolar-type H (+)-ATPase in murine macrophages.
GL Lukacs, OD Rotstein, S Grinstein
Journal of Biological Chemistry 265 (34), 21099-21107, 1990
Conformational and temperature-sensitive stability defects of the ΔF508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments
M Sharma, M Benharouga, W Hu, GL Lukacs
Journal of Biological Chemistry 276 (12), 8942-8950, 2001
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