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Leslie A. Crews
Leslie A. Crews
Assistant Professor of Medicine, UC San Diego
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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of ¥á-synuclein
P Desplats, HJ Lee, EJ Bae, C Patrick, E Rockenstein, L Crews, ...
Proceedings of the National Academy of Sciences 106 (31), 13010-13015, 2009
17292009
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of ¥á-synuclein
P Desplats, HJ Lee, EJ Bae, C Patrick, E Rockenstein, L Crews, ...
Proceedings of the National Academy of Sciences 106 (31), 13010-13015, 2009
17262009
Molecular mechanisms of neurodegeneration in Alzheimer's disease
L Crews, E Masliah
Human molecular genetics 19 (R1), R12-R20, 2010
8762010
Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study
MA Lemp, LA Crews, AJ Bron, GN Foulks, BD Sullivan
Cornea 31 (5), 472-478, 2012
7872012
Effects of ¥á-synuclein immunization in a mouse model of Parkinson¡¯s disease
E Masliah, E Rockenstein, A Adame, M Alford, L Crews, M Hashimoto, ...
Neuron 46 (6), 857-868, 2005
7082005
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer¡¯s and Parkinson¡¯s diseases
M Hashimoto, E Rockenstein, L Crews, E Masliah
Neuromolecular medicine 4, 21-35, 2003
6622003
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
O Singer, RA Marr, E Rockenstein, L Crews, NG Coufal, FH Gage, ...
Nature neuroscience 8 (10), 1343-1349, 2005
5222005
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease
E Masliah, E Rockenstein, M Mante, L Crews, B Spencer, A Adame, ...
PloS one 6 (4), e19338, 2011
4922011
A¥â vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
E Masliah, L Hansen, A Adame, L Crews, F Bard, C Lee, P Seubert, ...
Neurology 64 (1), 129-131, 2005
4512005
Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications
BD Sullivan, LA Crews, EM Messmer, GN Foulks, KK Nichols, ...
Acta ophthalmologica 92 (2), 161-166, 2014
4332014
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of ¥á-synucleinopathy
L Crews, B Spencer, P Desplats, C Patrick, A Paulino, E Rockenstein, ...
PloS one 5 (2), e9313, 2010
4212010
Deficiency in neuronal TGF-¥â signaling promotes neurodegeneration and Alzheimer¡¯s pathology
I Tesseur, K Zou, L Esposito, F Bard, E Berber, J Van Can, AH Lin, ...
The Journal of clinical investigation 116 (11), 3060-3069, 2006
3752006
Neuroprotective effects of regulators of the glycogen synthase kinase-3¥â signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid ¡¦
E Rockenstein, M Torrance, A Adame, M Mante, P Bar-On, JB Rose, ...
Journal of Neuroscience 27 (8), 1981-1991, 2007
3352007
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
IF Tsigelny, L Crews, P Desplats, GM Shaked, Y Sharikov, H Mizuno, ...
PloS one 3 (9), e3135, 2008
3232008
Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management
BD Sullivan, LA Crews, B Sönmez, MF de la Paz, E Comert, ...
Cornea 31 (9), 1000-1008, 2012
2572012
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human ¥á-synuclein under oligodendrocyte promoter: implications for multiple system atrophy
CW Shults, E Rockenstein, L Crews, A Adame, M Mante, G Larrea, ...
Journal of Neuroscience 25 (46), 10689-10699, 2005
2502005
Progressive accumulation of amyloid‐¥â oligomers in Alzheimer¡¯s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations ¡¦
E Pham, L Crews, K Ubhi, L Hansen, A Adame, A Cartier, D Salmon, ...
The FEBS journal 277 (14), 3051-3067, 2010
2462010
Dynamics of ¥á‐synuclein aggregation and inhibition of pore‐like oligomer development by ¥â‐synuclein
IF Tsigelny, P Bar‐On, Y Sharikov, L Crews, M Hashimoto, MA Miller, ...
The FEBS journal 274 (7), 1862-1877, 2007
2122007
Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis
L Crews, A Adame, C Patrick, A DeLaney, E Pham, E Rockenstein, ...
Journal of Neuroscience 30 (37), 12252-12262, 2010
2112010
Role of ¥á‐synuclein penetration into the membrane in the mechanisms of oligomer pore formation
IF Tsigelny, Y Sharikov, W Wrasidlo, T Gonzalez, PA Desplats, L Crews, ...
The FEBS journal 279 (6), 1000-1013, 2012
2072012
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