Katherine C Fein
Katherine C Fein
Senior Scientist, Oral Formulation Sciences, Merck
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Cited by
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Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
NG Lamson, A Berger, KC Fein, KA Whitehead
Nature biomedical engineering 4 (1), 84-96, 2020
ATRP-grown protein-polymer conjugates containing phenylpiperazine selectively enhance transepithelial protein transport
CS Cummings, K Fein, H Murata, RL Ball, AJ Russell, KA Whitehead
Journal of Controlled Release 255, 270-278, 2017
Structure-function analysis of phenylpiperazine derivatives as intestinal permeation enhancers
KC Fein, NG Lamson, KA Whitehead
Pharmaceutical Research 34, 1320-1329, 2017
The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology
JP Gleeson, KC Fein, N Chaudhary, R Doerfler, AN Newby, ...
International journal of pharmaceutics 593, 120120, 2021
Profiling of mature-stage human breast milk cells identifies six unique lactocyte subpopulations
JP Gleeson, N Chaudhary, KC Fein, R Doerfler, P Hredzak-Showalter, ...
Science Advances 8 (26), eabm6865, 2022
Oral delivery of peptide therapeutics in infants: Challenges and opportunities
JP Gleeson, KC Fein, KA Whitehead
Advanced drug delivery reviews 173, 112-124, 2021
Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size
KC Fein, JP Gleeson, AN Newby, KA Whitehead
European Journal of Pharmaceutics and Biopharmaceutics 170, 70-76, 2022
Thrifty, rapid intestinal monolayers (TRIM) using caco-2 epithelial cells for oral drug delivery experiments
NG Lamson, RL Ball, KC Fein, KA Whitehead
Pharmaceutical research 36, 1-12, 2019
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery
NG Lamson, KC Fein, JP Gleeson, AN Newby, S Xian, K Cochran, ...
Proceedings of the National Academy of Sciences 119 (33), e2207829119, 2022
Piperazine derivatives enhance epithelial cell monolayer permeability by increased cell force generation and loss of cadherin structures
S Zheng, K Lavrenyuk, NG Lamson, KC Fein, KA Whitehead, KN Dahl
ACS Biomaterials Science & Engineering 6 (1), 367-374, 2019
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
KC Fein, JP Gleeson, K Cochran, NG Lamson, R Doerfler, JR Melamed, ...
Bioengineering & Translational Medicine, e10342, 2022
From farm to pharmacy: strawberry-enabled oral delivery of protein drugs
NG Lamson, KC Fein, JP Gleeson, S Xian, A Newby, N Chaudhary, ...
bioRxiv, 2020.03. 11.987461, 2020
Placental drug transport and fetal exposure during pregnancy is determined by drug molecular size, chemistry, and conformation
KC Fein, ML Arral, JS Kim, AN Newby, KA Whitehead
Journal of Controlled Release 361, 29-39, 2023
Profiling of mature stage human breastmilk cells identifies host-defense lactocyte sub-populations
JP Gleeson, N Chaudhary, R Doerfler, KC Fein, T Hredzak-Showalter, ...
bioRxiv, 2021.10. 04.463125, 2021
Characterization and comparison of human and mouse milk cells
R Doerfler, S Yerneni, A Newby, N Chaudhary, A Shu, K Fein, ...
Plos one 19 (1), e0297821, 2024
Intestinal Permeation Enhancers Safely Enable the Oral Delivery of Macromolecules
K Fein
Carnegie Mellon University, 2020
Rational Selection of Intestinal Permeation Enhancers for Oral Macromolecular Drug Delivery
K Fein, K Whitehead
2019 AIChE Annual Meeting, 2019
Multiscale Structural Characterization of Epithelial Cell Monolayers Associated with the Addition of Permeability Enhancers for Enhancing Drug Delivery
S Zheng, K Fein, N Lamson, KN Dahl, K Lavrenyuk, K Whitehead
2018 AIChE Annual Meeting, 2018
Proteins Covalently Conjugated to Phenylpiperazine-Containing Polymers Experience Selectively Enhanced Intestinal Epithelial Transport
K Fein, C Cummings, H Murata, R Ball, A Russell, K Whitehead
2018 AIChE Annual Meeting, 2018
ATRP-Grown Protein-Polymer Conjugates Selectively Enhance Transepithelial Protein Transport
C Cummings, K Fein, H Murata, R Ball, A Russell, K Whitehead
2017 AIChE Annual Meeting, 2017
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