The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease YH Youm, KY Nguyen, RW Grant, EL Goldberg, M Bodogai, D Kim, ... Nature medicine 21 (3), 263-269, 2015 | 1781 | 2015 |
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing CD Camell, J Sander, O Spadaro, A Lee, KY Nguyen, A Wing, ... Nature 550 (7674), 119-123, 2017 | 378 | 2017 |
β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares EL Goldberg, JL Asher, RD Molony, AC Shaw, CJ Zeiss, C Wang, ... Cell reports 18 (9), 2077-2087, 2017 | 324 | 2017 |
Drivers of age‐related inflammation and strategies for healthspan extension EL Goldberg, VD Dixit Immunological reviews 265 (1), 63-74, 2015 | 267 | 2015 |
Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis CD Camell, P Günther, A Lee, EL Goldberg, O Spadaro, YH Youm, ... Cell metabolism 30 (6), 1024-1039. e6, 2019 | 150 | 2019 |
Ketogenic diet activates protective γδ T cell responses against influenza virus infection EL Goldberg, RD Molony, E Kudo, S Sidorov, Y Kong, VD Dixit, A Iwasaki Science immunology 4 (41), eaav2026, 2019 | 134 | 2019 |
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue EL Goldberg, I Shchukina, JL Asher, S Sidorov, MN Artyomov, VD Dixit Nature Metabolism 2 (1), 50-61, 2020 | 125 | 2020 |
Lifespan‐extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms EL Goldberg, MJ Romero‐Aleshire, KR Renkema, MS Ventevogel, ... Aging cell 14 (1), 130-138, 2015 | 94 | 2015 |
Growth hormone receptor deficiency protects against age-related NLRP3 inflammasome activation and immune senescence O Spadaro, EL Goldberg, CD Camell, YH Youm, JJ Kopchick, KY Nguyen, ... Cell reports 14 (7), 1571-1580, 2016 | 86 | 2016 |
Regulation of Nlrp3 inflammasome by dietary metabolites C Camell, E Goldberg, VD Dixit Seminars in immunology 27 (5), 334-342, 2015 | 75 | 2015 |
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis X Zhang, JG McDonald, B Aryal, A Canfrán‐Duque, EL Goldberg, E Araldi, ... Proceedings of the National Academy of Sciences 118 (47), e2107682118, 2021 | 58 | 2021 |
Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance JP Camporez, K Lyu, EL Goldberg, D Zhang, GW Cline, MJ Jurczak, ... The Journal of physiology 597 (15), 3885-3903, 2019 | 58 | 2019 |
Investigating ketone bodies as immunometabolic countermeasures against respiratory viral infections BJ Stubbs, AP Koutnik, EL Goldberg, V Upadhyay, PJ Turnbaugh, ... Med 1 (1), 43-65, 2020 | 57 | 2020 |
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2 EL Goldberg, I Shchukina, YH Youm, S Ryu, T Tsusaka, KC Young, ... Cell metabolism 33 (11), 2277-2287. e5, 2021 | 55 | 2021 |
How inflammation blunts innate immunity in aging EL Goldberg, AC Shaw, RR Montgomery Vaccines for older adults: current practices and future opportunities 43, 1-17, 2020 | 35 | 2020 |
Immune memory–boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections EL Goldberg, MJ Smithey, LK Lutes, JL Uhrlaub, J Nikolich-Žugich The Journal of Immunology 193 (2), 757-763, 2014 | 34 | 2014 |
Acute neonatal infections ‘lock-in’a suboptimal CD8+ T cell repertoire with impaired recall responses BD Rudd, V Venturi, NL Smith, K Nzingha, EL Goldberg, G Li, ... PLoS pathogens 9 (9), e1003572, 2013 | 32 | 2013 |
Bone marrow: an immunometabolic refuge during energy depletion EL Goldberg, VD Dixit Cell Metabolism 30 (4), 621-623, 2019 | 17 | 2019 |
Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice Y Kusne, EL Goldberg, SS Parker, SM Hapak, IY Maskaykina, WM Chew, ... Age 36, 199-212, 2014 | 13 | 2014 |
Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation EL Goldberg, A Letian, T Dlugos, C Leveau, VD Dixit Journal of Biological Chemistry 299 (3), 2023 | 12 | 2023 |