Boris Kholodenko
Boris Kholodenko
Professor of Systems Biology, University College Dublin
Verified email at - Homepage
Cited by
Cited by
Cell-signalling dynamics in time and space
BN Kholodenko
Nature reviews Molecular cell biology 7 (3), 165-176, 2006
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades
BN Kholodenko
European journal of biochemistry 267 (6), 1583-1588, 2000
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
NI Markevich, JB Hoek, BN Kholodenko
The Journal of cell biology 164 (3), 353-359, 2004
Quantification of short term signaling by the epidermal growth factor receptor
BN Kholodenko, OV Demin, G Moehren, JB Hoek
Journal of Biological Chemistry 274 (42), 30169-30181, 1999
Signalling ballet in space and time
BN Kholodenko, JF Hancock, W Kolch
Nature reviews Molecular cell biology 11 (6), 414-426, 2010
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
E Aksamitiene, A Kiyatkin, BN Kholodenko
Biochemical Society Transactions 40 (1), 139-146, 2012
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks
BN Kholodenko, A Kiyatkin, FJ Bruggeman, E Sontag, HV Westerhoff, ...
Proceedings of the National Academy of Sciences 99 (20), 12841-12846, 2002
The dynamic control of signal transduction networks in cancer cells
W Kolch, M Halasz, M Granovskaya, BN Kholodenko
Nature Reviews Cancer 15 (9), 515-527, 2015
Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
MR Birtwistle, M Hatakeyama, N Yumoto, BA Ogunnaike, JB Hoek, ...
Molecular systems biology 3 (1), 144, 2007
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
W Sturm, O. E., Orton, R., Grindlay, J., Birtwistle, M., Vyshemirsky, V ...
Sci Signal 3 (153), ra90, 2010
Quantitative analysis of signaling networks
HM Sauro, BN Kholodenko
Progress in biophysics and molecular biology 86 (1), 5-43, 2004
Why cytoplasmic signalling proteins should be recruited to cell membranes
BN Kholodenko, JB Hoek, HV Westerhoff
Trends in cell biology 10 (5), 173-178, 2000
Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling
N Borisov, E Aksamitiene, A Kiyatkin, S Legewie, J Berkhout, T Maiwald, ...
Molecular systems biology 5 (1), 256, 2009
Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
T Nakakuki, MR Birtwistle, Y Saeki, N Yumoto, K Ide, T Nagashima, ...
Cell 141 (5), 884-896, 2010
Spatial gradients of cellular phospho-proteins
GC Brown, BN Kholodenko
FEBS letters 457 (3), 452-454, 1999
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
A Kiyatkin, E Aksamitiene, NI Markevich, NM Borisov, JB Hoek, ...
Journal of biological chemistry 281 (29), 19925-19938, 2006
Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data
E Sontag, A Kiyatkin, BN Kholodenko
Bioinformatics 20 (12), 1877-1886, 2004
Evaluating strategies to normalise biological replicates of Western blot data
A Degasperi, MR Birtwistle, N Volinsky, J Rauch, W Kolch, ...
PloS one 9 (1), e87293, 2014
Frequency modulation of ERK activation dynamics rewires cell fate
H Ryu, M Chung, M Dobrzyński, D Fey, Y Blum, SS Lee, M Peter, ...
Molecular systems biology 11 (11), 838, 2015
Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors
BN Kholodenko
Journal of Experimental Biology 206 (12), 2073-2082, 2003
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