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Tin Lok Wong
Tin Lok Wong
Verified email at hku.hk
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Year
CRAF methylation by PRMT6 regulates aerobic glycolysis–driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
TL Wong, KY Ng, KV Tan, LH Chan, L Zhou, N Che, RLC Hoo, TK Lee, ...
Hepatology 71 (4), 1279-1296, 2020
872020
PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation
LH Chan, L Zhou, KY Ng, TL Wong, TK Lee, R Sharma, JH Loong, ...
Cell reports 25 (3), 690-701. e8, 2018
812018
Reprogramming of central carbon metabolism in cancer stem cells
TL Wong, N Che, S Ma
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (7 …, 2017
792017
FSTL1 promotes metastasis and Chemoresistance in esophageal squamous cell carcinoma through NFκB–BMP signaling cross-talk
MCC Lau, KY Ng, TL Wong, M Tong, TK Lee, XY Ming, S Law, NP Lee, ...
Cancer research 77 (21), 5886-5899, 2017
672017
FSTL1 secreted by activated fibroblasts promotes hepatocellular carcinoma metastasis and stemness
JJ Loh, TW Li, L Zhou, TL Wong, X Liu, VWS Ma, CM Lo, K Man, TK Lee, ...
Cancer research 81 (22), 5692-5705, 2021
532021
Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma
JHC Loong, TL Wong, M Tong, R Sharma, L Zhou, KY Ng, HJ Yu, CH Li, ...
The Journal of clinical investigation 131 (11), 2021
502021
Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression
L Zhou, HO Ken, TL Wong, Z Zhang, CH Chan, JHC Loong, N Che, HJ Yu, ...
Gut 71 (8), 1656-1668, 2022
372022
Caspase-3–Induced activation of SREBP2 drives drug resistance via promotion of cholesterol biosynthesis in hepatocellular carcinoma
EHK Mok, CON Leung, L Zhou, MML Lei, HW Leung, M Tong, TL Wong, ...
Cancer Research 82 (17), 3102-3115, 2022
322022
Chemotherapy‐enriched THBS2‐deficient cancer stem cells drive hepatocarcinogenesis through matrix softness induced histone H3 modifications
KY Ng, QT Shea, TL Wong, ST Luk, M Tong, CM Lo, K Man, JP Yun, ...
Advanced Science 8 (5), 2002483, 2021
292021
The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression
NPY Ho, CON Leung, TL Wong, EYT Lau, MML Lei, EHK Mok, HW Leung, ...
Cell Death & Disease 12 (2), 148, 2021
282021
PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors
Q Yan, Y Zhang, X Fang, B Liu, TL Wong, L Gong, S Liu, D Yu, M Liu, ...
Cell Death & Differentiation 28 (6), 1955-1970, 2021
212021
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability
N Che, KY Ng, TL Wong, M Tong, PWF Kau, LH Chan, TK Lee, MSY Huen, ...
Cancer Letters 501, 247-262, 2021
202021
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
M Tong, TL Wong, H Zhao, Y Zheng, YN Xie, CH Li, L Zhou, N Che, ...
Cell reports 36 (8), 2021
182021
A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment
F Xu, M Tong, CSW Tong, BKC Chan, HY Chu, TL Wong, JHC Fong, ...
Cancer Research 81 (24), 6219-6232, 2021
172021
Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen‐Activated Protein Kinase Kinase 6–Dependent p38 Mitogen‐Activated Protein Kinase Signaling to …
ST Luk, KY Ng, L Zhou, M Tong, TL Wong, H Yu, CM Lo, K Man, XY Guan, ...
Hepatology 72 (1), 183-197, 2020
172020
SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling
H Yu, L Zhou, JHC Loong, KH Lam, TL Wong, KY Ng, M Tong, VWS Ma, ...
Hepatology 78 (6), 1711-1726, 2023
112023
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
TL Wong, JJ Loh, S Lu, HHN Yan, HC Siu, R Xi, D Chan, MJF Kam, ...
Nature communications 14 (1), 2861, 2023
82023
Protein tyrosine kinase 7 (PTK7) promotes metastasis in hepatocellular carcinoma via SOX9 regulation and TGF-β Signaling
TLM Wong, TL Wong, L Zhou, K Man, J Purcell, TK Lee, JP Yun, S Ma
Cellular and Molecular Gastroenterology and Hepatology 15 (1), 13-37, 2023
82023
Long noncoding RNA URB1-antisense RNA 1 (AS1) suppresses sorafenib-induced ferroptosis in hepatocellular carcinoma by driving ferritin phase separation
Y Gao, M Tong, TL Wong, KY Ng, YN Xie, Z Wang, H Yu, JJ Loh, M Li, ...
ACS nano 17 (22), 22240-22258, 2023
52023
Deranged tyrosine metabolism drives tumorigenesis in liver cancer
M Tong, TL Wong, STC Luk, N Che, XY Guan, YF Yuan, TKW Lee, S Ma
Cancer Research 78 (13_Supplement), 1432-1432, 2018
12018
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