| Economic analysis of integrated continuous and batch pharmaceutical manufacturing: a case study SD Schaber, DI Gerogiorgis, R Ramachandran, JMB Evans, PI Barton, ... Industrial & Engineering Chemistry Research 50 (17), 10083-10092, 2011 | 561 | 2011 |
| An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process F Boukouvala, V Niotis, R Ramachandran, FJ Muzzio, MG Ierapetritou Computers & chemical engineering 42, 30-47, 2012 | 206 | 2012 |
| An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction R Singh, M Ierapetritou, R Ramachandran International journal of pharmaceutics 438 (1-2), 307-326, 2012 | 143 | 2012 |
| Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review Y Chen, O Yang, C Sampat, P Bhalode, R Ramachandran, M Ierapetritou Processes 8 (9), 1088, 2020 | 139 | 2020 |
| System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction R Singh, M Ierapetritou, R Ramachandran European Journal of Pharmaceutics and Biopharmaceutics 85 (3), 1164-1182, 2013 | 130 | 2013 |
| A systematic framework for onsite design and implementation of a control system in a continuous tablet manufacturing process R Singh, A Sahay, F Muzzio, M Ierapetritou, R Ramachandran Computers & chemical engineering 66, 186-200, 2014 | 111 | 2014 |
| Experimental studies on distributions of granule size, binder content and porosity in batch drum granulation: Inferences on process modelling requirements and process sensitivities R Ramachandran, JMH Poon, CFW Sanders, T Glaser, CD Immanuel, ... Powder Technology 188 (2), 89-101, 2008 | 106 | 2008 |
| Implementation of an advanced hybrid MPC–PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant R Singh, A Sahay, KM Karry, F Muzzio, M Ierapetritou, R Ramachandran International journal of pharmaceutics 473 (1-2), 38-54, 2014 | 105 | 2014 |
| A mechanistic model for breakage in population balances of granulation: Theoretical kernel development and experimental validation R Ramachandran, CD Immanuel, F Stepanek, JD Litster, FJ Doyle III Chemical Engineering Research and Design 87 (4), 598-614, 2009 | 105 | 2009 |
| Effective parameter estimation within a multi-dimensional population balance model framework R Ramachandran, PI Barton Chemical Engineering Science 65 (16), 4884-4893, 2010 | 104 | 2010 |
| A multi-scale, mechanistic model of a wet granulation process using a novel bi-directional PBM–DEM coupling algorithm D Barrasso, T Eppinger, FE Pereira, R Aglave, K Debus, SK Bermingham, ... Chemical Engineering Science 123, 500-513, 2015 | 94 | 2015 |
| Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies D Barrasso, R Ramachandran Chemical Engineering Research and Design 93, 304-317, 2015 | 92 | 2015 |
| A multi-scale hybrid CFD-DEM-PBM description of a fluid-bed granulation process M Sen, D Barrasso, R Singh, R Ramachandran Processes 2 (1), 89-111, 2014 | 86 | 2014 |
| Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation JMH Poon, R Ramachandran, CFW Sanders, T Glaser, CD Immanuel, ... Chemical Engineering Science 64 (4), 775-786, 2009 | 85 | 2009 |
| Multi-dimensional population balance model development and validation for a twin screw granulation process D Barrasso, A El Hagrasy, JD Litster, R Ramachandran Powder Technology 270, 612-621, 2015 | 84 | 2015 |
| A comparison of model order reduction techniques for a four-dimensional population balance model describing multi-component wet granulation processes D Barrasso, R Ramachandran Chemical engineering science 80, 380-392, 2012 | 84 | 2012 |
| A multi-dimensional population balance model approach to continuous powder mixing processes M Sen, R Ramachandran Advanced Powder Technology 24 (1), 51-59, 2013 | 82 | 2013 |
| Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process R Singh, AD Román-Ospino, RJ Romañach, M Ierapetritou, ... International journal of pharmaceutics 495 (1), 612-625, 2015 | 79 | 2015 |
| A reduced order PBM–ANN model of a multi-scale PBM–DEM description of a wet granulation process D Barrasso, A Tamrakar, R Ramachandran Chemical Engineering Science 119, 319-329, 2014 | 78 | 2014 |
| Computer-aided flowsheet simulation of a pharmaceutical tablet manufacturing process incorporating wet granulation F Boukouvala, A Chaudhury, M Sen, R Zhou, L Mioduszewski, ... Journal of Pharmaceutical Innovation 8, 11-27, 2013 | 76 | 2013 |
