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Sam Hay
Sam Hay
Professor of Biophysical Chemistry, University of Manchester
manchester.ac.uk의 이메일 확인됨 - 홈페이지
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Good vibrations in enzyme-catalysed reactions
S Hay, NS Scrutton
Nature chemistry 4 (3), 161-168, 2012
3022012
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ...
Nature 517 (7535), 513-516, 2015
2932015
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
2242015
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
1952015
Quantum biology: An update and perspective
Y Kim, F Bertagna, EM D’souza, DJ Heyes, LO Johannissen, ET Nery, ...
Quantum Reports 3 (1), 80-126, 2021
1292021
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
S Hay, MJ Sutcliffe, NS Scrutton
Proceedings of the National Academy of Sciences 104 (2), 507-512, 2007
1202007
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
S Zhang, DJ Heyes, L Feng, W Sun, LO Johannissen, H Liu, CW Levy, ...
Nature 574 (7780), 722-725, 2019
1062019
Fast protein motions are coupled to enzyme H-transfer reactions
CR Pudney, A Guerriero, NJ Baxter, LO Johannissen, JP Waltho, S Hay, ...
Journal of the American Chemical Society 135 (7), 2512-2517, 2013
1012013
Direct Analysis of Donor− Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions
CR Pudney, LO Johannissen, MJ Sutcliffe, S Hay, NS Scrutton
Journal of the American Chemical Society 132 (32), 11329-11335, 2010
932010
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction
CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton
Journal of the American Chemical Society 131 (47), 17072-17073, 2009
932009
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase
J Pang, S Hay, NS Scrutton, MJ Sutcliffe
Journal of the American Chemical Society 130 (22), 7092-7097, 2008
892008
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays
S Miwa, A Treumann, A Bell, G Vistoli, G Nelson, S Hay, T von Zglinicki
Free Radical Biology and Medicine 90, 173-183, 2016
872016
α-Secondary isotope effects as probes of “tunneling-ready” configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models
CR Pudney, S Hay, MJ Sutcliffe, NS Scrutton
Journal of the American Chemical Society 128 (43), 14053-14058, 2006
832006
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment
LO Johannissen, S Hay, NS Scrutton, MJ Sutcliffe
The Journal of Physical Chemistry B 111 (10), 2631-2638, 2007
702007
Nature of the energy landscape for gated electron transfer in a dynamic redox protein
S Hay, S Brenner, B Khara, AM Quinn, SEJ Rigby, NS Scrutton
Journal of the American Chemical Society 132 (28), 9738-9745, 2010
692010
Barrier compression enhances an enzymatic hydrogen‐transfer reaction
S Hay, CR Pudney, TA McGrory, J Pang, MJ Sutcliffe, NS Scrutton
Angewandte Chemie International Edition 48 (8), 1452-1454, 2009
692009
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase
V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ...
Acs Catalysis 7 (9), 6268-6282, 2017
672017
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms
CR Pudney, S Hay, J Pang, C Costello, D Leys, MJ Sutcliffe, NS Scrutton
Journal of the American Chemical Society 129 (45), 13949-13956, 2007
652007
Decoupled associative and dissociative processes in strong yet highly dynamic host–guest complexes
EA Appel, F Biedermann, D Hoogland, J Del Barrio, MD Driscoll, S Hay, ...
Journal of the American Chemical Society 139 (37), 12985-12993, 2017
632017
Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase
AJ Dunford, SEJ Rigby, S Hay, AW Munro, NS Scrutton
Biochemistry 46 (17), 5018-5029, 2007
632007
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