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Fenfei Leng
Fenfei Leng
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Structure-based design of a new bisintercalating anthracycline antibiotic
JB Chaires, F Leng, T Przewloka, I Fokt, YH Ling, R Perez-Soler, ...
Journal of medicinal chemistry 40 (3), 261-266, 1997
1831997
Ultratight DNA binding of a new bisintercalating anthracycline antibiotic
F Leng, W Priebe, JB Chaires
Biochemistry 37 (7), 1743-1753, 1998
1461998
Energetics of echinomycin binding to DNA
F Leng, JB Chaires, MJ Waring
Nucleic Acids Research 31 (21), 6191-6197, 2003
1012003
Potent stimulation of transcription-coupled DNA supercoiling by sequence-specific DNA-binding proteins
F Leng, R McMacken
Proceedings of the National Academy of Sciences 99 (14), 9139-9144, 2002
802002
Structure of a DNA−Bisdaunomycin Complex,
GG Hu, X Shui, F Leng, W Priebe, JB Chaires, LD Williams
Biochemistry 36 (20), 5940-5946, 1997
781997
Base specific and regioselective chemical cross-linking of daunorubicin to DNA
F Leng, R Savkur, I Fokt, T Przewloka, W Priebe, JB Chaires
Journal of the American Chemical Society 118 (20), 4731-4738, 1996
731996
Isomerization kinetics of AT hook decapeptide solution structures
ER Schenk, ME Ridgeway, MA Park, F Leng, F Fernandez-Lima
Analytical chemistry 86 (2), 1210-1214, 2014
722014
Specific recognition of AT-rich DNA sequences by the mammalian high mobility group protein AT-hook 2: a SELEX study
T Cui, F Leng
Biochemistry 46 (45), 13059-13066, 2007
662007
Dividing a supercoiled DNA molecule into two independent topological domains
F Leng, B Chen, DD Dunlap
Proceedings of the National Academy of Sciences 108 (50), 19973-19978, 2011
612011
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals
M Ahmad, Y Xue, SK Lee, JL Martindale, W Shen, W Li, S Zou, ...
Nucleic Acids Research 44 (13), 6335-6349, 2016
602016
HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells
T Deng, ZI Zhu, S Zhang, F Leng, S Cherukuri, L Hansen, ...
Molecular and cellular biology 33 (16), 3377-3389, 2013
462013
DNA supercoiling: a regulatory signal for the λ repressor
Y Ding, C Manzo, G Fulcrand, F Leng, D Dunlap, L Finzi
Proceedings of the National Academy of Sciences 111 (43), 15402-15407, 2014
432014
Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay
Y Miao, T Cui, F Leng, WD Wilson
Analytical biochemistry 374 (1), 7-15, 2008
432008
Transcription-coupled hypernegative supercoiling of plasmid DNA by T7 RNA polymerase in Escherichia coli topoisomerase I-deficient strains
R Samul, F Leng
Journal of molecular biology 374 (4), 925-935, 2007
422007
Energetics of binding the mammalian high mobility group protein HMGA2 to poly (dA-dT) 2 and poly (dA)-poly (dT)
T Cui, S Wei, K Brew, F Leng
Journal of molecular biology 352 (3), 629-645, 2005
422005
Coupling DNA supercoiling to transcription in defined protein systems
F Leng, L Amado, R McMacken
Journal of Biological Chemistry 279 (46), 47564-47571, 2004
422004
DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli
G Fulcrand, S Dages, X Zhi, P Chapagain, BS Gerstman, D Dunlap, ...
Scientific reports 6 (1), 19243, 2016
412016
A rapid and sensitive high-throughput screening method to identify compounds targeting protein–nucleic acids interactions
N Alonso, R Guillen, JW Chambers, F Leng
Nucleic acids research 43 (8), e52-e52, 2015
352015
Selective inhibition of bacterial topoisomerase I by alkynyl-bisbenzimidazoles
N Ranjan, G Fulcrand, A King, J Brown, X Jiang, F Leng, DP Arya
MedChemComm 5 (6), 816-825, 2014
292014
DNA bending by the mammalian high-mobility group protein AT hook 2
B Chen, J Young, F Leng
Biochemistry 49 (8), 1590-1595, 2010
282010
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