Generalized simulated annealing for global optimization: the GenSA package. Y Xiang, S Gubian, B Suomela, J Hoeng R J. 5 (1), 13, 2013 | 405 | 2013 |
Systems toxicology: from basic research to risk assessment SJ Sturla, AR Boobis, RE FitzGerald, J Hoeng, RJ Kavlock, K Schirmer, ... Chemical research in toxicology 27 (3), 314-329, 2014 | 353 | 2014 |
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing U Marx, TB Andersson, A Bahinski, M Beilmann, S Beken, FR Cassee, ... Altex 33 (3), 272, 2016 | 332 | 2016 |
Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program MR Smith, B Clark, F Lüdicke, JP Schaller, P Vanscheeuwijck, J Hoeng, ... Regulatory toxicology and pharmacology 81, S17-S26, 2016 | 291 | 2016 |
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development U Marx, T Akabane, TB Andersson, E Baker, M Beilmann, S Beken, ... Altex 37 (3), 365, 2020 | 218 | 2020 |
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction G Lo Sasso, WK Schlage, S Boué, E Veljkovic, MC Peitsch, J Hoeng Journal of translational medicine 14 (1), 146, 2016 | 194 | 2016 |
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers C Mathis, C Poussin, D Weisensee, S Gebel, A Hengstermann, A Sewer, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 304 (7 …, 2013 | 160 | 2013 |
A lung/liver-on-a-chip platform for acute and chronic toxicity studies D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar, D Marescotti, ... Lab on a Chip 18 (24), 3814-3829, 2018 | 150 | 2018 |
Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge AL Tarca, M Lauria, M Unger, E Bilal, S Boue, K Kumar Dey, J Hoeng, ... Bioinformatics 29 (22), 2892-2899, 2013 | 131 | 2013 |
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by … B Phillips, B Titz, U Kogel, D Sharma, P Leroy, Y Xiang, G Vuillaume, ... Food and chemical toxicology 109, 315-332, 2017 | 129 | 2017 |
An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate … B Phillips, E Veljkovic, S Boué, WK Schlage, G Vuillaume, F Martin, B Titz, ... Toxicological Sciences 149 (2), 411-432, 2016 | 120 | 2016 |
Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models F Martin, A Sewer, M Talikka, Y Xiang, J Hoeng, MC Peitsch BMC bioinformatics 15, 1-24, 2014 | 112 | 2014 |
Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks F Martin, TM Thomson, A Sewer, DA Drubin, C Mathis, D Weisensee, ... BMC systems biology 6, 1-18, 2012 | 111 | 2012 |
Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems S Boue, M Talikka, JW Westra, W Hayes, A Di Fabio, J Park, WK Schlage, ... Database 2015, bav030, 2015 | 106 | 2015 |
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a … B Phillips, E Veljkovic, MJ Peck, A Buettner, A Elamin, E Guedj, ... Food and Chemical Toxicology 80, 328-345, 2015 | 104 | 2015 |
A network-based approach to quantifying the impact of biologically active substances. J Hoeng, R Deehan, D Pratt, F Martin, A Sewer, TM Thomson, DA Drubin, ... Drug discovery today 17 (9-10), 413-418, 2011 | 100 | 2011 |
Verification of systems biology research in the age of collaborative competition P Meyer, LG Alexopoulos, T Bonk, A Califano, CR Cho, A De La Fuente, ... Nature biotechnology 29 (9), 811-815, 2011 | 97 | 2011 |
Exploring the microbiome in health and disease: Implications for toxicology E Scotti, S Boué, GL Sasso, F Zanetti, V Belcastro, C Poussin, N Sierro, ... Toxicology Research and application 1, 2397847317741884, 2017 | 93 | 2017 |
A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue WK Schlage, JW Westra, S Gebel, NL Catlett, C Mathis, BP Frushour, ... BMC systems biology 5, 1-15, 2011 | 93 | 2011 |
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with … ET Wong, U Kogel, E Veljkovic, F Martin, Y Xiang, S Boue, G Vuillaume, ... Regulatory Toxicology and Pharmacology 81, S59-S81, 2016 | 92 | 2016 |