Follow
Matthew J. Sykes, PhD, BSc (hons), FRACI (C Chem)
Matthew J. Sykes, PhD, BSc (hons), FRACI (C Chem)
Associate Professor in Computational Medicinal Chemistry, University of South Australia
Verified email at unisa.edu.au - Homepage
Title
Cited by
Cited by
Year
Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids
KM Knights, MJ Sykes, JO Miners
Expert opinion on drug metabolism & toxicology 3 (2), 159-168, 2007
1102007
Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates
MJ Sykes, RA McKinnon, JO Miners
Journal of medicinal chemistry 51 (4), 780-791, 2008
912008
Discovery of 5‐(2‐(Phenylamino)pyrimidin‐4‐yl)thiazol‐2(3H)‐one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation
S Diab, T Teo, M Kumarasiri, P Li, M Yu, F Lam, SKC Basnet, MJ Sykes, ...
ChemMedChem 9 (5), 962-972, 2014
842014
DNA binding of an organic dppz-based intercalator
T Phillips, I Haq, AJHM Meijer, H Adams, I Soutar, L Swanson, MJ Sykes, ...
Biochemistry 43 (43), 13657-13665, 2004
802004
The Gaussian Generalized Born model: application to small molecules
JA Grant, BT Pickup, MJ Sykes, CA Kitchen, A Nicholls
Physical Chemistry Chemical Physics 9 (35), 4913-4922, 2007
692007
Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells
T Teo, M Yu, Y Yang, T Gillam, F Lam, MJ Sykes, S Wang
Cancer letters 357 (2), 612-623, 2015
502015
Targeting Pim kinases for cancer treatment: opportunities and challenges
BT Le, M Kumarasiri, JRJ Adams, M Yu, R Milne, MJ Sykes, S Wang
Future medicinal chemistry 7 (1), 35-53, 2015
442015
Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes
MJ Sykes, MJ Sorich, JO Miners
Journal of chemical information and modeling 46 (6), 2661-2673, 2006
412006
Pharmacologic inhibition of MNKs in acute myeloid leukemia
T Teo, F Lam, M Yu, Y Yang, SKC Basnet, H Albrecht, MJ Sykes, S Wang
Molecular pharmacology 88 (2), 380-389, 2015
392015
A systematic review and meta-analysis considering the risk for congenital heart defects of antidepressant classes and individual antidepressants
C De Vries, S Gadzhanova, MJ Sykes, M Ward, E Roughead
Drug Safety 44, 291-312, 2021
362021
Identification of a Novel Oligomerization Disrupting Mutation in CRYΑA Associated with Congenital Cataract in a South Australian Family
KJ Laurie, A Dave, T Straga, E Souzeau, T Chataway, MJ Sykes, T Casey, ...
Human mutation 34 (3), 435-438, 2013
362013
An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis
T Teo, Y Yang, M Yu, SKC Basnet, T Gillam, J Hou, RM Schmid, ...
European journal of medicinal chemistry 103, 539-550, 2015
342015
A simple formula for dielectric polarisation energies: The Sheffield Solvation Model
JA Grant, BT Pickup, MJ Sykes, CA Kitchen, A Nicholls
Chemical physics letters 441 (1-3), 163-166, 2007
342007
Synthesis and Extended Activity of Triazole‐Containing Macrocyclic Protease Inhibitors
AD Pehere, M Pietsch, M Gütschow, PM Neilsen, DS Pedersen, S Nguyen, ...
Chemistry–A European Journal 19 (24), 7975-7981, 2013
312013
Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome
S Sharma, S Martin, MJ Sykes, A Dave, AW Hewitt, KP Burdon, M Ronci, ...
Experimental eye research 146, 212-223, 2016
282016
Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions
EF McCoy, MJ Sykes
Journal of chemical information and computer sciences 43 (2), 545-553, 2003
272003
Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance
MR Nussio, MJ Sykes, JO Miners, JG Shapter
ChemMedChem: Chemistry Enabling Drug Discovery 2 (3), 366-373, 2007
262007
Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride
MR Nussio, MJ Sykes, JO Miners, JG Shapter
Langmuir 25 (2), 1086-1090, 2009
252009
Discovery of CDK5 inhibitors through structure-guided approach
NZ Khair, JL Lenjisa, S Tadesse, M Kumarasiri, SKC Basnet, ...
ACS Medicinal Chemistry Letters 10 (5), 786-791, 2019
222019
AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers
MR Nussio, NH Voelcker, JO Miners, BC Lewis, MJ Sykes, JG Shapter
Chemistry and physics of lipids 163 (2), 182-189, 2010
222010
The system can't perform the operation now. Try again later.
Articles 1–20