Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids KM Knights, MJ Sykes, JO Miners Expert opinion on drug metabolism & toxicology 3 (2), 159-168, 2007 | 110 | 2007 |
Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates MJ Sykes, RA McKinnon, JO Miners Journal of medicinal chemistry 51 (4), 780-791, 2008 | 91 | 2008 |
Discovery of 5‐(2‐(Phenylamino)pyrimidin‐4‐yl)thiazol‐2(3H)‐one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation S Diab, T Teo, M Kumarasiri, P Li, M Yu, F Lam, SKC Basnet, MJ Sykes, ... ChemMedChem 9 (5), 962-972, 2014 | 84 | 2014 |
DNA binding of an organic dppz-based intercalator T Phillips, I Haq, AJHM Meijer, H Adams, I Soutar, L Swanson, MJ Sykes, ... Biochemistry 43 (43), 13657-13665, 2004 | 80 | 2004 |
The Gaussian Generalized Born model: application to small molecules JA Grant, BT Pickup, MJ Sykes, CA Kitchen, A Nicholls Physical Chemistry Chemical Physics 9 (35), 4913-4922, 2007 | 69 | 2007 |
Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells T Teo, M Yu, Y Yang, T Gillam, F Lam, MJ Sykes, S Wang Cancer letters 357 (2), 612-623, 2015 | 50 | 2015 |
Targeting Pim kinases for cancer treatment: opportunities and challenges BT Le, M Kumarasiri, JRJ Adams, M Yu, R Milne, MJ Sykes, S Wang Future medicinal chemistry 7 (1), 35-53, 2015 | 44 | 2015 |
Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes MJ Sykes, MJ Sorich, JO Miners Journal of chemical information and modeling 46 (6), 2661-2673, 2006 | 41 | 2006 |
Pharmacologic inhibition of MNKs in acute myeloid leukemia T Teo, F Lam, M Yu, Y Yang, SKC Basnet, H Albrecht, MJ Sykes, S Wang Molecular pharmacology 88 (2), 380-389, 2015 | 39 | 2015 |
A systematic review and meta-analysis considering the risk for congenital heart defects of antidepressant classes and individual antidepressants C De Vries, S Gadzhanova, MJ Sykes, M Ward, E Roughead Drug Safety 44, 291-312, 2021 | 36 | 2021 |
Identification of a Novel Oligomerization Disrupting Mutation in CRYΑA Associated with Congenital Cataract in a South Australian Family KJ Laurie, A Dave, T Straga, E Souzeau, T Chataway, MJ Sykes, T Casey, ... Human mutation 34 (3), 435-438, 2013 | 36 | 2013 |
An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis T Teo, Y Yang, M Yu, SKC Basnet, T Gillam, J Hou, RM Schmid, ... European journal of medicinal chemistry 103, 539-550, 2015 | 34 | 2015 |
A simple formula for dielectric polarisation energies: The Sheffield Solvation Model JA Grant, BT Pickup, MJ Sykes, CA Kitchen, A Nicholls Chemical physics letters 441 (1-3), 163-166, 2007 | 34 | 2007 |
Synthesis and Extended Activity of Triazole‐Containing Macrocyclic Protease Inhibitors AD Pehere, M Pietsch, M Gütschow, PM Neilsen, DS Pedersen, S Nguyen, ... Chemistry–A European Journal 19 (24), 7975-7981, 2013 | 31 | 2013 |
Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome S Sharma, S Martin, MJ Sykes, A Dave, AW Hewitt, KP Burdon, M Ronci, ... Experimental eye research 146, 212-223, 2016 | 28 | 2016 |
Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions EF McCoy, MJ Sykes Journal of chemical information and computer sciences 43 (2), 545-553, 2003 | 27 | 2003 |
Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance MR Nussio, MJ Sykes, JO Miners, JG Shapter ChemMedChem: Chemistry Enabling Drug Discovery 2 (3), 366-373, 2007 | 26 | 2007 |
Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride MR Nussio, MJ Sykes, JO Miners, JG Shapter Langmuir 25 (2), 1086-1090, 2009 | 25 | 2009 |
Discovery of CDK5 inhibitors through structure-guided approach NZ Khair, JL Lenjisa, S Tadesse, M Kumarasiri, SKC Basnet, ... ACS Medicinal Chemistry Letters 10 (5), 786-791, 2019 | 22 | 2019 |
AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers MR Nussio, NH Voelcker, JO Miners, BC Lewis, MJ Sykes, JG Shapter Chemistry and physics of lipids 163 (2), 182-189, 2010 | 22 | 2010 |