David Dickens
David Dickens
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Transport of gabapentin by LAT1 (SLC7A5)
D Dickens, SD Webb, S Antonyuk, A Giannoudis, A Owen, S Rädisch, ...
Biochemical pharmacology 85 (11), 1672-1683, 2013
Lamotrigine is a substrate for OCT1 in brain endothelial cells
D Dickens, A Owen, A Alfirevic, A Giannoudis, A Davies, B Weksler, ...
Biochemical pharmacology 83 (6), 805-814, 2012
Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol
D Dickens, GN Chiduza, GSA Wright, M Pirmohamed, SV Antonyuk, ...
Scientific reports 7 (1), 1-13, 2017
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
D Lam, D Dickens, EB Reid, SHY Loh, N Moisoi, LM Martins
Proceedings of the National Academy of Sciences 106 (29), 11978-11983, 2009
A multi-system approach assessing the interaction of anticonvulsants with P-gp
D Dickens, SR Yusof, NJ Abbott, B Weksler, IA Romero, PO Couraud, ...
PLoS One 8 (5), e64854, 2013
ABCB1 single nucleotide polymorphisms (1236C> T, 2677G> T, and 3435C> T) do not affect transport activity of human P-glycoprotein
D Dickens, A Owen, A Alfirevic, M Pirmohamed
Pharmacogenetics and genomics 23 (6), 314-323, 2013
Cellular uptake of the atypical antipsychotic clozapine is a carrier-mediated process
D Dickens, S Radisch, GN Chiduza, A Giannoudis, MJ Cross, H Malik, ...
Molecular pharmaceutics 15 (8), 3557-3572, 2018
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein
M Vogler, D Dickens, MJS Dyer, A Owen, M Pirmohamed, GM Cohen
Biochemical and biophysical research communications 408 (2), 344-349, 2011
Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry
A Alfirevic, J Durocher, A Elati, W León, D Dickens, S Rädisch, H Box, ...
Pharmacogenomics 16 (9), 919-928, 2015
Development of fluorine-18 labeled metabolically activated tracers for imaging of drug efflux transporters with positron emission tomography
K Sander, E Galante, T Gendron, E Yiannaki, N Patel, TL Kalber, A Badar, ...
Journal of Medicinal Chemistry 58 (15), 6058-6080, 2015
A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine
S Rädisch, D Dickens, T Lang, L Bonnett, R Arlanov, MR Johnson, ...
The Pharmacogenomics Journal 14 (5), 481-487, 2014
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
S Gutbier, S Kyriakou, S Schildknecht, AK Ückert, M Brüll, F Lewis, ...
Archives of toxicology 94 (9), 3105-3123, 2020
The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells
K Ide, S Takahashi, K Sakai, Y Taga, T Ueno, D Dickens, R Jenkins, ...
Journal of Biological Chemistry 297 (1), 2021
Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex
W Patel, L Rimmer, M Smith, L Moss, MA Smith, HR Snodgrass, ...
Molecular pharmaceutics 18 (1), 113-123, 2021
Drug Transporters at the Blood–Brain Barrier
D Dickens, S Radisch, M Pirmohamed
RSC Drug Discovery Series, 2016
LAT1, a novel pharmacological target for the treatment of glioblastoma
N Cappoli, MD Jenkinson, CD Russo, D Dickens
Biochemical Pharmacology, 115103, 2022
Inflammatory Bowel Disease: A Personalized Approach
A Konidari, D Dickens, M Pirmohamed
Frontiers in Pediatrics 8, 620545, 2021
The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier
W Patel, M Smith, R Snodgrass, M Pirmohamed, A Alfirevic, D Dickens
BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2621-2622, 2020
The interaction of baclofen and 5-hydroxy-L-tryptohan with the LAT1 (SLC7A5) transporter
M Harvey, W Patel, D Dickens
BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2544-2545, 2020
In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line
P Curley, M Giardiello, NJ Liptrott, D Dickens, DM Moss, JJ Hobson, ...
Journal of Interdisciplinary Nanomedicine 2 (3), 157-169, 2017
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